Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1296 |
| PDBID: | 5EU7 |
| Chains: | EC_A |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.64 |
| Reference: | 10.1016/j.str.2016.08.015 |
| Antibody | |
| Antibody: | Fab2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 integrase catalytic |
| Antigen mutation: | No |
| Durg Target: | Q7ZJM1; P03367; P12497; P03366; P04587; P03369; P35963; P04585; P12499; |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >5EU7_E|Chain C[auth E], D[auth F]|FAB Heavy Chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFNLYSYSMHWVRQAPGKGLEWVAYIYPYSGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARESSYFYDGSYSYYDYEGAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: C
Mutation: NULL
| >5EU7_C|Chain E[auth C], F[auth D]|FAB light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQSSYSPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5EU7_A|Chain A, B|Integrase|Human immunodeficiency virus 1 (11676) SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACDWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKGGIGGYSAGERIVDIIATDIQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition E: ASN28 SER31 TYR32 SER33 TYR50 TYR52 TYR54 SER55 SER57 GLU99 SER100 SER101 TYR102 TYR108 SER109 TYR110 TYR111 ASP112 GLU114 C: SER31 SER50 ALA51 SER52 SER53 A: LEU68 GLU69 LYS156 GLU157 LYS159 LYS160 ILE161 ILE162 GLY163 GLN164 VAL165 ARG166 ASP167 GLN168 PHE181 ILE182 LYS185 LYS186 ARG187 LYS188 GLY189 GLY190 ILE191 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
