Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1273 |
| PDBID: | 5DUR |
| Chains: | BD_A |
| Organism: | Homo sapiens, Influenza A virus (A/Anhui/1/2005(H5N1)) |
| Method: | XRD |
| Resolution (Å): | 2.82 |
| Reference: | 10.1038/ncomms9855 |
| Antibody | |
| Antibody: | 100F4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >5DUR_B|Chain A[auth B], D[auth H]|Heavy Chain of Antibody 100F4|Homo sapiens (9606) QLQLQESGLGLVKPSETLSLTCTVSGDSVSSGSYYWSWLRQPPGKGLEWIGNMHGSGHTNYNPSLKSRVTITPDTSKNHFSLRLSSVTAADTAVYYCARALLTTVTTFEYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCP |
Light Chain: D
Mutation: NULL
| >5DUR_D|Chain B[auth D], E[auth L]|Light Chain of Antibody 100F4|Homo sapiens (9606) QSALTQPPSVSGAPGQRVTIPCTGGSSNIGAGYSVHWYQQLPGTAPKLLIYGSNSRPSGVPDRFSGSKSGTSASLAITGLRPEDEADYYCQSYDSSLSGSQVFGAGTRVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >5DUR_A|Chain C[auth A], F[auth C]|Hemagglutinin|Influenza A virus (A/Anhui/1/2005(H5N1)) (370810) ADPDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSDHEASSGVSSACPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNDAAEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMDFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAIVKSEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER30 SER31 GLY32 SER33 TYR34 TYR35 HIS54 GLY55 SER56 HIS58 ASN60 THR75 LEU101 LEU102 THR103 THR104 VAL105 GLU109 D: ALA31 GLY32 TYR33 SER34 TYR51 GLY52 SER53 SER55 LYS68 SER69 TYR93 SER95 SER98 A: ASP68 GLU69 ILE71 ASN72 VAL73 PRO74 GLU75 HIS110 PHE111 GLU112 LYS113 ILE114 GLN115 PRO118 LYS119 SER120 TYR137 GLN138 THR140 SER142 ARG145 ASN146 THR167 ASN168 GLN169 GLU170 TYR252 LYS255 VAL257 LYS258 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
