Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1271 |
| PDBID: | 5DUP |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Anhui/1/2005(H5N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.05 |
| Reference: | 10.1038/ncomms9855 |
| Antibody | |
| Antibody: | AVFluIgG03 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5DUP_H|Chain B[auth H]|AVFluIgG03 Heavy Chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRVSCTNSGFTFSNYAMSWVRQAPGKGLEWVSAISGNGGSGTYYADSVKGRFTISRDNSKNTMYLQMNSLRAEDTAVYYCVRDDSYDGGGHYGLHNWFDSWGQGTLVTVSSSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTS |
Light Chain: L
Mutation: NULL
| >5DUP_L|Chain C[auth L]|AVFluIgG03 Light Chain|Homo sapiens (9606) SVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSVVVFGGGTKLEIKGTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5DUP_A|Chain A|Hemagglutinin|Influenza A virus (A/Anhui/1/2005(H5N1)) (370810) ADPDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSDHEASSGVSSACPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNDAAEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMDFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAIVKSEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN31 TYR60 ASP101 SER102 TYR103 ASP104 GLY105 GLY106 GLY107 HIS108 TYR109 LEU111 HIS112 TRP114 L: GLY32 ASP34 TYR51 GLY52 ASN53 SER54 ASN55 ARG56 PHE64 SER65 GLY66 LYS68 A: TYR91 GLU126 SER128 SER129 GLY130 VAL131 SER132 SER133 GLY139 THR140 PRO141 TRP149 ILE151 LYS152 LYS153 ASN154 ASN155 GLU186 LYS189 LEU190 LYS218 GLY221 GLN222 SER223 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
