Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1270 |
| PDBID: | 5DUM |
| Chains: | HL_A |
| Organism: | Homo sapiens, Influenza A virus (A/Anhui/1/2005(H5N1)) |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1038/ncomms9855 |
| Antibody | |
| Antibody: | 65C6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5DUM_H|Chain A[auth H]|65C6 Heavy Chain|Homo sapiens (9606) EVQLVQSGAEVKKPGESLRISCKGFAYSSTYFWISWVRQMPGKGLEWMGRIDPTDSYINYSPSFQGHVTISVDRSISTVYLQWSSLKASDTAMYYCAYHRRGHFYGSGSAWDWFESWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVESASCDKTHTCP |
Light Chain: L
Mutation: NULL
| >5DUM_L|Chain B[auth L]|65C6 Light Chain|Homo sapiens (9606) EIVLTQSPLTLSVSPGERATLSCRASQSVSSNLAWYQQMPGQAPRLLIYGASTRATGIPARLSGSASGTEFTLTISSLQSEDFAVYYCQQYNNWPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5DUM_A|Chain C[auth A]|Hemagglutinin|Influenza A virus (A/Anhui/1/2005(H5N1)) (370810) ADPDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSDHEASSGVSSACPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNDAAEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMDFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAIVKSEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 TYR31 ARG50 ASP52 THR54 ASP55 TYR57 ASN59 ARG101 GLY102 HIS103 PHE104 TYR105 GLY106 SER107 GLY108 TRP111 L: ASN93 TRP94 A: ILE114 GLN115 ILE116 ILE117 PRO118 SER120 SER121 SER123 ASP124 PRO158 THR159 LYS161 ARG162 SER163 TYR164 ASN165 THR167 ASN168 ASN240 PHE241 GLU242 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
