Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 127 |
| PDBID: | 1ORS |
| Chains: | BA_C |
| Organism: | Mus musculus, Aeropyrum pernix |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1038/nature01580 |
| Antibody | |
| Antibody: | 33H1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | voltage-dependent potassium channel |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1ORS_B|Chain B|33H1 Fab heavy chain|Mus musculus (10090) DVQLQESGPGLVKPSQSLSLTCTVTGYSITNNYAWNWIRQFPGNKLEWMGYINYSGTTSYNPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYFCVRGYDYFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCG |
Light Chain: A
Mutation: NULL
| >1ORS_A|Chain A|33H1 Fab light chain|Mus musculus (10090) QIVLTQSPAIMSASLGDRVTMTCTASSSVSSSYLHWYQQKPGSSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCHQFHRSLTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >1ORS_C|Chain C|potassium channel|Aeropyrum pernix (56636) DVMEHPLVELGVSYAALLSVIVVVVEYTMQLSGEYLVRLYLVDLILVIILWADYAYRAYKSGDPAGYVKKTLYEIPALVPAGLLALIEGHLAGLGLFRLVRLLRFLRILLIISRGSKFLSAIADAADKLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR33 PHE92 HIS93 B: THR30 ASN31 ASN32 TYR33 ALA34 TYR51 ASN53 TYR54 SER55 GLY99 TYR100 ASP101 TYR102 PHE103 C: GLU107 ALA111 GLY112 LEU113 GLY114 LEU115 PHE116 ARG117 VAL119 ARG120 ARG123 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
