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Entry information

Complex
AACDB_ID: 126
PDBID: 1ORQ
Chains: BA_C
Organism: Mus musculus, Aeropyrum pernix
Method: XRD
Resolution (Å): 3.20
Reference: 10.1038/nature01580
Antibody
Antibody: 6E1 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: voltage-dependent potassium channel
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: B
Mutation: NULL

>1ORQ_B|Chain B|6E1 Fab heavy chain|Mus musculus (10090)
DVQLQESGPGLVKPSQSLSLTCTVTGYSITSLYAWNWIRQFPGNKLEWMGYINYSGYTSYNPSLKSRISITRDTSKNQFFLQLHSVTTEDTATYSCTRGVDYFAMDYWGQGASVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSDLYTLSSSVTVTSNTWPSQSITCNVAHPASSTKVDKKIVPRD

Light Chain: A
Mutation: NULL

>1ORQ_A|Chain A|6E1 Fab light chain|Mus musculus (10090)
ENVLTQSPAIMSPSPGEKVTMTCRARSSVSSSYLHWYQQKSGASPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSVEAEDTATYYCQQYSGNPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

Antigen

Chain: C
Mutation: NULL

>1ORQ_C|Chain C|potassium channel|Aeropyrum pernix (56636)
IGDVMEHPLVELGVSYAALLSVIVVVVECTMQLSGEYLVRLYLVDLILVIILWADYAYRAYKSGDPAGYVKKTLYEIPALVPAGLLALIEGHLAGLGLFRLVRLLRFLRILLIISRGSKFLSAIADAADKIRFYHLFGAVMLTVLYGAFAIYIVEYPDPNSSIKSVFDALWWAVVTATTVGYGDVVPATPIGKVIGIAVMLTGISALTLLIGTVSNMFQKILV

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

A: TYR33 TYR92

B: THR30 SER31 LEU32 TYR33 ALA34 TYR51 ILE52 ASN53 TYR54 SER55 TYR57 THR71 ARG72 ASP73 THR74 SER75 LYS76 PHE80 GLN82 VAL100 ASP101 TYR102 PHE103

C: TYR54 LEU55 LEU58 TYR59 GLU107 GLY108 ALA111 GLY112 LEU113 GLY114 LEU115 PHE116 ARG117 VAL119 ARG120 ARG123

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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