Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1258 |
| PDBID: | 5DFW |
| Chains: | H_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.33 |
| Reference: | 10.1080/19420862.2015.1117720 |
| Antibody | |
| Antibody: | CD81K13 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | CD81 antigen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: H
Mutation: NULL
| >5DFW_H|Chain B[auth H]|SINGLE CHAIN FV FRAGMENT|Mus musculus (10090) EVRLHQSAAQLVQPGASVRLSCTTSGFNFKDSYLHWVKQRPAQGLEWIGRIDTGNGNVKFDPKFQDKATITTDIPSMTAYLHLSNLTSEDTAVYYCVPYGYGFHSWGDGTTLTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPASLSVSVGETVTITCRASENIYRTLAWYLQKQGKSPQLLVYGATTLADGVPSRFSGSGSGTQYYLKINSLQSEDFGTYHCQHFWGTPWTFGGGTKVEIK |
Antigen
Chain: A
Mutation: NULL
| >5DFW_A|Chain A|CD81 antigen|Homo sapiens (9606) GSGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN153 ASP156 SER196 TYR197 HIS199 ARG251 ASP253 ASN288 LYS292 TYR351 GLY352 TYR353 GLY396 PHE397 ILE502 TYR571 ARG596 THR597 GLY651 ALA694 THR695 THR696 TRP754 GLY755 THR796 A: VAL136 ASP137 ASP138 ASP139 ALA140 ASN141 LYS144 ALA145 LYS148 THR149 THR167 SER168 LEU170 LYS171 ASN172 ASN173 LEU174 SER177 GLY178 ILE181 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
