Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1256 |
| PDBID: | 5DFV |
| Chains: | CD_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1080/19420862.2015.1117720 |
| Antibody | |
| Antibody: | K04 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | CD81 antigen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >5DFV_C|Chain C, E|FAB HEAVY CHAIN|Mus musculus (10090) QVQLQQSGPELVKPGASVKISCKASGYTFSSSWMNWVKQRPGKGLEWIGRIYSGDGDAIYNGKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYFCAREGKTGDLLLRSWGQGSALTVSSAKTTAPSVYPLVPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSGLYTLSSSVTVTSNTWPSQTITCNVAHPASSTKVDKKIEPRVP |
Light Chain: D
Mutation: NULL
| >5DFV_D|Chain D, F|FAB LIGHT CHAIN|Mus musculus (10090) DIVLTQSPASLSVSLGQRATISCRASKSVSTSIYSYMHWYQQKPGQPPKLLIKYASYLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCEHSREFPFTFGTGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >5DFV_A|Chain A, B|CD81 antigen|Homo sapiens (9606) GSGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER156 TRP197 ARG251 TYR253 ASP288 ASP290 ALA291 ILE292 LYS353 THR354 GLY355 ASP394 LEU395 D: THR581 SER582 ILE594 TYR595 TYR597 TYR651 ARG754 GLU755 PHE796 A: GLN125 GLN129 GLN132 GLN133 ALA134 VAL135 VAL136 ASP137 ASP139 LYS144 THR161 LEU162 THR163 ALA164 LEU165 THR167 SER168 LYS171 ASN172 ILE181 ILE182 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
