Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 125 |
| PDBID: | 1OP9 |
| Chains: | A_B |
| Organism: | Camelus dromedarius, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.86 |
| Reference: | 10.1038/nature01870 |
| Antibody | |
| Antibody: | HL6 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Lysozyme C |
| Antigen mutation: | No |
| Durg Target: | P61626 |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >1OP9_A|Chain A|HL6 camel VHH fragment|Camelus dromedarius (9838) QVQLQESGGGSVQAGGSLRLSCSASGYTYISGWFRQAPGKEREGVAAIRSSDGTTYYADSVKGRFTISQDNAKNTVYLQMNSLKPEDTAMYYCAATEVAGWPLDIGIYDYWGQGTEVTVSS |
Antigen
Chain: B
Mutation: NULL
| >1OP9_B|Chain B|Lysozyme C|Homo sapiens (9606) KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLN1 TYR27 TYR29 ARG49 SER51 ASP52 TYR56 GLU97 VAL98 ALA99 GLY100 TRP101 PRO102 GLY106 ILE107 ASP109 TYR110 B: ARG14 LEU15 GLY16 TYR20 ALA76 CYS77 HIS78 LEU79 ALA90 ASP91 VAL93 ALA94 CYS95 LYS97 ARG98 ARG101 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
