Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1245 |
| PDBID: | 5D93 |
| Chains: | CB_A |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.1093/protein/gzv067 |
| Antibody | |
| Antibody: | Fab316.1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Mus musculus Quiescin sulfhydryl oxidase-1(Trx) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >5D93_C|Chain B[auth C], E[auth F]|Heavy Chain of Fab Fragment from a Mouse QSOX1-Specific Antibody|Mus musculus (10090) QVQLQQSGPELVKPGASVKISCKASGYSFTSYYIHWVKQRPGQGLEWIGWIYPGSYNTEYSEKFKGKATLTADTSSSTAYMQLSSLTSEDSAVYYCARSEDWFAYWGQGTLVTVSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: B
Mutation: NULL
| >5D93_B|Chain C[auth B], F[auth E]|Light Chain of Fab Fragment from a Mouse QSOX1-Specific Antibody|Mus musculus (10090) QIVLTQSPAIMSASPGEKVTISCSASSSVSYMYWYHQKPGSSPKPWIYRTSNLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCQQYHSYPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5D93_A|Chain A, D|Sulfhydryl oxidase 1|Mus musculus (10090) GSHMSVLYSSSDPLTLLDADSVRPTVLGSSSAWAVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVLDCAEETNSAVCREFNIAGFPTVRFFQAFTKNGSGATLPGAGANVQTLRMRLIDALESHRDTWPPACPPLEPAKLNDIDGFFTRNKADYLALVFEREDSYLGREVTLDLSQYHAVAVRRVLNTESDLVNKFGVTDFPSCYLLLRNGSVSRVPVLVESRSFYTSYLRGLPGLTRD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER31 TYR33 TRP50 TYR52 SER55 ASN57 THR58 GLU59 GLU100 ASP101 B: SER28 VAL29 SER30 TYR31 TYR33 ARG49 SER66 GLY67 TYR90 HIS91 SER92 TYR93 A: MET35 SER36 VAL37 LEU38 SER71 TRP72 GLY74 HIS75 ILE77 ALA78 PHE79 PRO81 THR82 LYS84 GLU85 ALA142 GLY143 ALA144 ASN145 VAL146 THR148 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
