Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 123 |
| PDBID: | 1OB1 |
| Chains: | AB_C |
| Organism: | Mus musculus, Plasmodium falciparum |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1016/s0022-2836(03)00376-0 |
| Antibody | |
| Antibody: | G17.12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum MSP1-19 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >1OB1_A|Chain A, D|ANTIBODY, HEAVY CHAIN|MUS MUSCULUS (10090) DIVMTQTPAIMSAFLGERVTMTCTATSSLSSSYLHWYQQKPGSSPKLWIYTTSNLASGVPSRFSGSGSGTSYSLTISSMEAEDAATYYCHQFHHSPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Light Chain: B
Mutation: NULL
| >1OB1_B|Chain B, E|ANTIBODY, LIGHT CHAIN|MUS MUSCULUS (10090) ELQLVQSGPQLKKPGETVRISCKASGYTFTTAGIQWVQRLPGKDLKWIGWINTHSGVPQYADDFKGRFAFSLETSASTAFLQIINLKNEDTATYFCARNYYRFDGGMDFWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEP |
Antigen
Chain: C
Mutation: NULL
| >1OB1_C|Chain C, F|MAJOR MEROZOITE SURFACE PROTEIN|PLASMODIUM FALCIPARUM (5833) NISQHQCVKKQCPQNSGCFRHLDEREECKCLLNYKQEGDKCVENPNPTCNENNGGCDADAKCTEEDSGSNGKKITCECTKPDSYPLFDGIFCSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: SER29 SER30 TYR32 PHE91 HIS92 HIS93 SER94 TYR96 B: THR30 THR31 ALA32 GLY33 TRP50 THR52 HIS53 GLN58 ASN95 TYR96 TYR97 ARG98 C: VAL8 LYS9 LYS10 GLN11 CYS12 PRO13 GLN14 ASP23 GLU24 ARG25 GLU26 CYS28 GLN36 GLY38 ASP39 LYS40 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
