Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1220 |
| PDBID: | 5C6T |
| Chains: | HL_A |
| Organism: | Human herpesvirus 5 strain Towne, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.60 |
| Reference: | 10.1038/ncomms9176 |
| Antibody | |
| Antibody: | 1G2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human cytomegalovirus (HCMV) glycoprotein B |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5C6T_H|Chain B[auth H]|1G2 Fab heavy chain|Homo sapiens (9606) QLQLQESGPGLVKPSETLSLTCTVSGASIDRSTYYWGWIRQPPGKGLEWIANIYYNGRAVYSPSLKSRVTISVDTSKNQFSLKVRSLTAADTAVYYCATRWNYFFDFDYWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGSENLYFQ |
Light Chain: L
Mutation: NULL
| >5C6T_L|Chain C[auth L]|1G2 Fab light chain|Homo sapiens (9606) QSVLTQPPSASGTPGQRVTISCSGSSSNIETNYVSWYQQFPGTAPKLLIYRNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEAEYYCGTWDDNSWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >5C6T_A|Chain A|Envelope glycoprotein B|Human cytomegalovirus (10363) MESRIWCLVVCVNLCIVCLGAAVSTKYPYRVCSMAQGTDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNIVAHTFKVRVYQKVLTFRRSYAYHRTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKTMQLMPDDYSNTHSTRYVTVKDQWHSRGSTNLTRETSNLNCMVTITTARSKYPYHFFATSTGDVVDISPFYNGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWEASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSVFETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNSTKSSTDGNNATHLSNMESVHNLVYAQLQFTYDTLRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVKVLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVDYLFKRMIDLSSISTVDSMIALDIDPLENTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 ARG31 SER32 THR33 TYR34 TYR55 ARG58 TRP101 ASN102 TYR103 PHE104 PHE105 TYR109 L: TYR50 ARG51 PRO56 SER57 A: ASP275 TYR280 GLY282 THR283 ARG285 ASN286 PHE290 GLY291 GLU292 ASN293 ALA294 ASP295 PHE297 PHE298 ILE299 PHE300 PRO301 LEU321 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
