Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1218 |
| PDBID: | 5C0S |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/New Caledonia/20/1999(H1N1)), HIV-1 M |
| Method: | XRD |
| Resolution (Å): | 4.30 |
| Reference: | 10.1038/nm.3927 |
| Antibody | |
| Antibody: | CR6261 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Diridavumab(Phase-II) |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | Q53I07; P35961; P12488; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5C0S_H|Chain B[auth H]|CR6261 antibody heavy chain|Homo sapiens (9606) EVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >5C0S_L|Chain C[auth L]|CR6261 antibody light chain|Homo sapiens (9606) QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVLGAAAGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >5C0S_A|Chain A|Hemagglutinin, Envelope glycoprotein, Fibritin fusion protein|Influenza A virus (381512) DTICIGYHANNSTDTVDTVLEKNVTVTHSVNLGSGLRMVTGLRNIPQRETRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMGGDPEWDREINNYTSIIYSLIEESQNQQENGTGGGSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNNECMESVKNGTYDYPKYSEESKLNREKIDPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLSGRLVPRGSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY26 GLY27 PRO28 PHE29 ARG30 SER31 PRO52 ILE53 PHE54 THR56 PHE74 GLY97 TYR98 GLN99 A: HIS8 HIS28 VAL30 ASN31 LEU32 THR40 VAL66 ASP67 GLY68 TRP69 GLN86 THR89 GLN90 ILE93 ASN94 THR97 ASN98 VAL100 ASN101 ILE104 GLU105 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
