Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1217 |
| PDBID: | 5C0R |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/New Caledonia/20/1999(H1N1)), HIV-1 M |
| Method: | XRD |
| Resolution (Å): | 3.19 |
| Reference: | 10.1038/nm.3927 |
| Antibody | |
| Antibody: | C179 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | Q53I07; P35961; P12488; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5C0R_H|Chain C[auth H]|C179 Fab heavy chain|Mus musculus (10090) EVKLVESGGGLVQPGGSLRLSCGTSGFTLTDDYMTWVRQPPGKALEWLGFIRDRANGYTTEYSASVKGRFTISRDNSQSIVYLQMNTLRVEDSATYYCARPKGYFPYAMDYWGQGTSVIVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCK |
Light Chain: L
Mutation: NULL
| >5C0R_L|Chain B[auth L]|C179 Fab light chain|Mus musculus (10090) DIQMTQSPASQSASLGESVTITCLASQTIGTWLAWYQQKPGKSPQLLIYAATSLADGVPSRFSGSGSGTKFSFKISSLQAEDFVSYYCQQLYSTPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >5C0R_A|Chain A|Hemagglutinin, Envelope glycoprotein, Fibritin fusion protein|Influenza A virus (381512) DTICIGYHANNSTDTVDTVLEKNVTVTHSVNLGWGLRMVTGLRNIPQRETRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMGGWMEWDREINNYTSIIYSLIEESQNQQENGTGGGSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNNECMESVKNGTYDYPKYSEESKLNREKIDPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLSGRLVPRGSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: GLY30 THR31 TRP32 TYR49 ALA50 THR52 SER53 ASP56 SER67 H: PHE27 LEU29 LYS96 GLY97 TYR98 PHE99 ASP101 TYR102 A: HIS8 HIS28 SER29 VAL30 THR40 VAL66 ASP67 GLY68 TRP69 GLN86 LYS87 THR89 GLN90 ASN91 ILE93 ASN94 THR97 ASN98 VAL100 ASN101 ILE104 GLU232 LYS235 ASN236 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
