Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1216 |
| PDBID: | 5C0N |
| Chains: | CD_B |
| Organism: | Mus musculus, Oryctolagus cuniculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1126/scitranslmed.aac6336 |
| Antibody | |
| Antibody: | CA33 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Fatty acid-binding protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >5C0N_C|Chain B[auth C], E[auth H]|Fab CA33 Heavy chain|Oryctolagus cuniculus (9986) QSVEESGGRLVTPGTPLTLTCTVSGFSLSTYYMSWVRQAPGKGLEWIGIIYPSGSTYCASWAKGRFTISKASTTVDLKITSPTTEDTATYFCARPDNDGTSGYLSGFGLWGQGTLVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: D
Mutation: NULL
| >5C0N_D|Chain C[auth D], F[auth L]|Fab CA33 light chain|Oryctolagus cuniculus (9986) DVVMTQTPASVSEPVGGTVTIKCQASEDISRYLVWYQQKPGQPPKRLIYKASTLASGVPSRFKGSGSGTDFTLTISDLECDDAATYYCQCTYGTYAGSFFYSFGGGTEVVVERTDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDCTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: B
Mutation: NULL
| >5C0N_B|Chain A, D[auth B]|Fatty acid-binding protein, adipocyte|Mus musculus (10090) MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: TYR51 ASN97 ASP98 TYR103 LEU104 D: ASP28 SER30 ARG31 TYR32 LYS50 SER67 GLY68 THR69 TYR92 GLY93 THR94 TYR95 ALA96 B: THR7 LYS9 LEU10 VAL11 SER12 SER13 MET35 ALA36 LYS37 ASN39 GLU54 THR56 PHE57 GLU129 ARG130 ALA131 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
