Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1190 |
| PDBID: | 5ANY |
| Chains: | LP_H |
| Organism: | Chikungunya virus, Mus musculus |
| Method: | EM |
| Resolution (Å): | 16.90 |
| Reference: | 10.1016/j.cell.2015.10.050 |
| Antibody | |
| Antibody: | CHK265 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | chikungunya virus E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: L
Mutation: NULL
| >5ANY_L|Chain I, J, K, L|FAB CHK265|MUS MUSCULUS (10090) QIQLVQSGREVKNPGETVKISCKASGYTFTEYPMLWVKQAPGKGFRWMGLIYTNTGEPTYAEEFKGRFVFSLEISASTAYLQINNLTNEDTATYFCVRDYFISLDYWGQGTTLTVSSAKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSGLYTLSSSVTVTSNTWPSQTITCNVAHPASSTKVDKKIESRR |
Light Chain: P
Mutation: NULL
| >5ANY_P|Chain M, N, O, P|FAB|MUS MUSCULUS (10090) QAVVTQESALTTSPGETVTLTCRSNIGAVTSSNCANWVQEKPDHFFTGLIGDTNNRRSGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYNNLWVFGGGTKLTVLGQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADC |
Antigen
Chain: H
Mutation: NULL
| >5ANY_H|Chain B, D, F, H|E2|CHIKUNGUNYA VIRUS (37124) NVYKATRPYLAHCPDCGEGHSCHSPVALERIRNEATDGTLKIQVSLQIGIKTDDSHDWTKLRYMDNHMPADAERAGLFVRTSAPCTITGTMGHFILARCPKGETLTVGFTDSRKISHSCTHPFHHDPPVIGREKFHSRPQHGKELPCSTYVQSTAATTEEIEVHMPPDTPDRTLMSQQSGNVKITVNGQTVRYKCNCGGSNEGLTTTDKVINNCKVDQCHAAVTNHKKWQYNSPLVPRNAELGDRKGKIHIPFPLANVTCRVPKARNPTVTYGKNQVIMLLYPDHPTLLSYRNMGEEPNYQEEWVMHKKEVVLTVPTEGLEVTWGNNEPYKYWPQLSTNGTAHGHPHEIILYYY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR96 PHE97 ILE98 SER99 P: GLY528 ALA529 SER530 ASN531 CYS532 ASP550 THR551 ASN552 ASN553 LEU566 TRP591 ASN593 ASN594 TRP596 H: GLN683 GLN684 SER685 GLY686 ASN687 TYR699 CYS703 GLY704 GLY705 SER706 THR713 ASP714 LYS715 VAL716 ILE717 ASN718 ASN719 CYS720 LYS721 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
