Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1173 |
| PDBID: | 5A3I |
| Chains: | GH_E |
| Organism: | Influenza A virus (A/Viet Nam/1203/2004(H5N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.89 |
| Reference: | 10.1073/pnas.1510816112 |
| Antibody | |
| Antibody: | FLD194 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >5A3I_G|Chain C, G|ANTI-HAEMAGGLUTININ HA1 FAB HEAVY CHAIN|HOMO SAPIENS (9606) EVQLVQSGAEVKKPGESLKISCKGSGYSFSDYWIGWVRQMPGEGLEWMGIIYPASSEIRYSPSFQGLVTISRDKSINTASLQWSSLKASDTAIYYCARHASCSARSCYWGPVDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: H
Mutation: NULL
| >5A3I_H|Chain D, H|ANTI-HAEMAGGLUTININ HA1 FAB LIGHT CHAIN|HOMO SAPIENS (9606) DIVMTQSPLSLPVSPGEPASISCRSSQSLLHGNGYNYLDWYLQKPGQSPRLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQALQTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >5A3I_E|Chain A, E|HEMAGGLUTININ|INFLUENZA A VIRUS (A/VIETNAM/1203/2004(H5N1)) (284218) DPDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSSHEASLGVSSACPYQGKSSFFRNVVWLIKKDSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVKGLSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLAIGLRNSPQRETR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: TYR27 SER28 SER30 ASP31 TYR52 ALA54 SER55 GLU57 SER101 CYS102 SER103 ALA104 ARG105 SER106 CYS107 TYR108 GLY110 PRO111 H: HIS31 GLY32 ASN33 TYR35 TYR37 TYR54 LEU55 ASN58 E: ASP68 ILE71 ASN72 GLU112 LYS113 ILE114 GLN115 ILE116 ILE117 PRO118 SER120 SER121 SER123 TYR137 GLN138 LYS140 ARG145 ARG162 SER163 TYR164 ASN165 THR167 GLU251 TYR252 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
