Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1171 |
| PDBID: | 4ZYP |
| Chains: | DE_C |
| Organism: | Human respiratory syncytial virus A2, Tequatrovirus T4, Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 5.50 |
| Reference: | 10.1371/journal.ppat.1005035 |
| Antibody | |
| Antibody: | AM14 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | respiratory syncytial virus (RSV) Fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; P03420; P11209; |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >4ZYP_D|Chain F[auth D], H[auth F], J[auth H]|AM14 antibody Fab heavy chain|Homo sapiens (9606) EVQLVESGGGVVQPGRSLRLSCAASGFSFSHYAMHWVRQAPGKGLEWVAVISYDGENTYYADSVKGRFSISRDNSKNTVSLQMNSLRPEDTALYYCARDRIVDDYYYYGMDVWGQGATVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: E
Mutation: NULL
| >4ZYP_E|Chain G[auth E], I[auth G], K[auth I]|AM14 antibody light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCQASQDIKKYLNWYHQKPGKVPELLMHDASNLETGVPSRFSGRGSGTDFTLTISSLQPEDIGTYYCQQYDNLPPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >4ZYP_C|Chain A, B, C|Fusion glycoprotein F0,Fibritin|Human respiratory syncytial virus A (strain A2) (11259) QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGGLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: HIS31 TYR52 ASP53 GLU55 ILE97 VAL98 ASP99 E: LYS30 TYR32 ASP50 ASP92 ASN93 C: GLN26 ASN426 LYS427 ASN428 ARG429 ILE431 ILE432 SER443 LYS445 GLY446 ASP448 LYS461 GLU463 LYS465 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
