Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1163 |
| PDBID: | 4ZSO |
| Chains: | BA_E |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 4ZSO Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Natural cytotoxicity triggering receptor 3 ligand 1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >4ZSO_B|Chain B, D|Antibody Heavy Chain|Homo sapiens (9606) MQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGQGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCAREGLGALLRDLYYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI |
Light Chain: A
Mutation: NULL
| >4ZSO_A|Chain A, C|Antibody Light Chain|Homo sapiens (9606) MQIVLTQSPALMSASPGEKVTMTCSASSSVSYMYWYQQKPRSSPKPWIYLTSNLASGVPARFCGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: E
Mutation: NULL
| >4ZSO_E|Chain E, F|Natural cytotoxicity triggering receptor 3 ligand 1|Homo sapiens (9606) ADLGSMDLKVEMMAGGTQITPLNDNVTIFCNIFYSQPLNITSMGITWFWKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEYRCEVVVTPLKAQGTVQLEVVASPASRLLLDQVGMKENEDKYMCESSGFYPEAINITWEKQTQKFPHPIEISEDVITGPTIKNMDGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSETEKTDNFSAAAHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR31 TYR33 TYR48 LEU49 SER51 ASN52 SER91 SER92 ASN93 B: GLN1 GLY26 TYR27 THR28 SER31 TYR32 ASN33 TYR52 ASN55 ASP57 ARG98 GLU99 LEU101 GLY102 ALA103 LEU105 ARG106 E: ASN41 TRP67 SER69 PHE72 LYS74 GLU75 VAL76 LYS77 VAL78 GLU87 PHE89 ARG90 PRO91 GLY92 PRO110 GLY111 GLN113 GLU115 GLU116 MET203 ASP204 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
