Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1160 |
| PDBID: | 4ZS6 |
| Chains: | CD_B |
| Organism: | Homo sapiens, Middle East respiratory syndrome-related coronavirus |
| Method: | XRD |
| Resolution (Å): | 3.17 |
| Reference: | 10.1038/srep13133 |
| Antibody | |
| Antibody: | MERS-27 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | MERS-CoV RBD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >4ZS6_C|Chain B[auth C], E[auth H]|fab Heavy Chain|Homo sapiens (9606) EVQLLETGGGLVKPGGSLRLSCAASGFSLSDYYMNWIRQAPGKGLEWVAYISSSSGYTNYGDSVKGRFTISRDHAKNSLYLQMNSLRVEDTAVYYCVRDRDDFWSGYYKHWGLGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKT |
Light Chain: D
Mutation: NULL
| >4ZS6_D|Chain A[auth D], D[auth L]|fab Light Chain|Homo sapiens (9606) AIRMTQSPSFLSASVGDRVTITCRASQDINSFLAWYQQRPGKAPKLLIYGASNLETGVPSRFSGGGSGTDFTLTISSLQPEDIATYYCQQYDKLPTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >4ZS6_B|Chain C[auth A], F[auth B]|S protein|Middle East respiratory syndrome coronavirus (1335626) EAKPSGSVVEQAEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCSRLLSDDRTEVPQLVNANQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: GLN27 ASP28 ASN30 PHE32 TYR91 ASP92 LYS93 LEU94 PRO95 C: TYR33 ASN35 TYR50 SER52 TYR57 THR58 ASN59 PHE103 TRP104 GLY106 B: THR392 ASN398 PRO494 LEU495 VAL527 SER528 ILE529 VAL530 PRO531 SER532 THR533 TRP535 GLU536 ASP537 GLY538 ASP539 TYR540 TYR541 ARG542 TRP553 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
