Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 116 |
| PDBID: | 1NMB |
| Chains: | HL_N |
| Organism: | Influenza A virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.1016/s0969-2126(00)00074-5 |
| Antibody | |
| Antibody: | NC10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | N9 NEURAMINIDASE |
| Antigen mutation: | No |
| Durg Target: | P03472 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1NMB_H|Chain C[auth H]|FAB NC10|Mus musculus (10090) QVQLQQPGAELVKPGASVRMSCKASGYTFTNYNMYWVKQSPGQGLEWIGIFYPGNGDTSYNQKFKDKATLTADKSSNTAYMQLSSLTSEDSAVYYCARSGGSYRYDGGFDYWGQGTTLTVSS |
Light Chain: L
Mutation: NULL
| >1NMB_L|Chain B[auth L]|FAB NC10|Mus musculus (10090) DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQNPDGTVKLLIYYTSNLHSEVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQDFTLPFTFGGGTKLEIRRA |
Antigen
Chain: N
Mutation: NULL
| >1NMB_N|Chain A[auth N]|N9 NEURAMINIDASE|Influenza A virus (11320) MNPNQKILCTSATALVIGTIAVLIGIVNLGLNIGLHLKPSCNCSRSQPEATNASQTIINNYYNETNITQISNTNIQVEERASREFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRDLISWPLSSPPTVYNSRVECIGWSSTSCHDGRARMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCQNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLTGTAKHIEECSCYGEQAGVTCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGGNTWLGRTISIASRSGYEMLKVPNALTDDRSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ILE2 GLN27 ASP28 SER30 TYR32 TYR50 ASP91 PHE92 THR93 LEU94 H: GLY53 ASN54 ASP56 THR57 SER58 TYR99 N: PRO328 ASN329 ASP330 PRO331 THR332 TYR341 PRO342 GLY343 ASN344 ILE366 SER367 ILE368 ALA369 SER370 SER372 ASN400 THR401 TRP403 LYS432 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
