Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1154 |
| PDBID: | 4ZFO |
| Chains: | AB_F |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.molonc.2015.03.010 |
| Antibody | |
| Antibody: | J22.9-xi Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 17(CD269) |
| Antigen mutation: | No |
| Durg Target: | Q02223 |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >4ZFO_A|Chain C[auth A], E[auth H]|J22.9-xi Fab, Heavy Chain|Mus musculus (10090) QVQLQQSGGGLVQPGGSLKLSCAASGIDFSRYWMSWVRRAPGKGLEWIGEINPDSSTINYAPSLKDKFIISRDNAKNTLYLQMSKVRSEDTALYYCASLYYDYGDAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPA |
Light Chain: B
Mutation: NULL
| >4ZFO_B|Chain D[auth B]|J22.9-xi Fab, Light Chain|Mus musculus (10090) DIVMTQSQRFMTTSVGDRVSVTCKASQSVDSNVAWYQQKPRQSPKALIFSASLRFSGVPARFTGSGSGTDFTLTISNLQSEDLAEYFCQQYNNYPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: F
Mutation: NULL
| >4ZFO_F|Chain A[auth F], F[auth K]|Tumor necrosis factor receptor superfamily member 17|Homo sapiens (9606) MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER31 ASN32 ALA34 TYR36 PHE49 SER50 SER52 LEU53 PHE55 GLY66 SER67 GLN89 TYR91 TYR94 LEU96 A: TRP33 GLU50 LEU99 TYR100 TYR101 ALA106 F: TYR13 PHE14 ASP15 SER16 LEU17 LEU18 HIS19 ALA20 CYS21 ILE22 PRO23 LEU26 ARG27 SER30 THR32 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
