Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 114 |
| PDBID: | 1NFD |
| Chains: | HG_D |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1093/emboj/17.1.10 |
| Antibody | |
| Antibody: | H57 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | N15 ALPHA-BETA T cell RECEPTOR |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1NFD_H|Chain F, H|H57 FAB|Mus musculus (10090) EVYLVESGGDLVQPGSSLKVSCAASGFTFSDFWMYWVRQAPGKGLEWVGRIKNIPNNYATEYADSVRGRFTISRDDSRNSIYLQMNRLRVDDTAIYYCTRAGRFDHFDYWGQGTMVTVSSATTTAPSVYPLAPACDSTTSTTDTVTLGCLVKGYFPEPVTVSWNSGALTSGVHTFPSVLHSGLYSLSSSVTVPSSTWPKQPITCNVAHPASSTKVDKKIEPR |
Light Chain: G
Mutation: NULL
| >1NFD_G|Chain E, G|H57 FAB|Mus musculus (10090) YELIQPSSASVTVGETVKITCSGDQLPKNFAYWFQQKSDKNILLLIYMDNKRPSGIPERFSGSTSGTTATLTISGAQPEDEAAYYCLSSYGDNNDLVFGSGTQLTVLRGPKSSPKVTVFPPSPEELRTNKATLVCLVNDFYPGSATVTWKANGATINDGVKTTKPSKQGQNYMTSSYLSLTADQWKSHNRVSCQVTHEGETVEKSLSPAECL |
Antigen
Chain: D
Mutation: NULL
| >1NFD_D|Chain B, D|N15 ALPHA-BETA T-CELL RECEPTOR|Mus musculus (10090) DSGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPSRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVLEDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: LEU28 PRO29 LYS30 ASN31 PHE32 TYR34 TYR49 MET50 ASP51 LYS53 THR66 SER91 LEU96 H: TRP33 TYR35 ARG50 ASN53 ALA95 GLY96 ARG97 PHE98 PHE100 D: GLU14 GLU117 ASP118 LEU119 ARG120 ASN121 THR123 GLU221 GLU222 ASP223 LYS224 TRP225 PRO226 GLU227 GLY228 SER229 PRO230 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
