Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1126 |
| PDBID: | 4YUE |
| Chains: | HL_C |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.19 |
| Reference: | 10.1016/j.immuni.2015.04.015 |
| Antibody | |
| Antibody: | S4B6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4YUE_H|Chain A[auth H]|S4B6 Fab heavy chain|Mus musculus (10090) ADPEVQLQESGAELVRPGTSVKLSCKVSGDTITAYYLHFVRQRPGQGLEWIGRIDPEDDSTKYAENFKNKATFTADASSNTAYLRLSSLTSEDTATYFCTTVTFYYSRELRWFAYWGQGTLVTVSSAETTAPSVYPLAPGTALKSNSMVTLGCLVKGYFPEPVTVTWNSGALSSGVHTFPAVLQSGLYTLTSSVTVPSSTWSSQAVTCNVAHPASSTKVDKKIVPRECSRGGLEVLFQ |
Light Chain: L
Mutation: NULL
| >4YUE_L|Chain B[auth L]|S4B6 Fab light chain|Mus musculus (10090) ADPDIQVTQSPASLSASLEEIVTITCQASQDIGNYLSWYQQKLGKSPQLLIHSATSLADGVPSRFSGSRSGTQYSLKINRLQVEDTGIYYCLQHYSTPYTFGAGTKLELKRADAAPTVSIFPPSSEQLASGGASVVCLLNNFYPKDISVKWKIDGSERQNGVLDSVTDQDSKDSTYSMSSTLTLTKAEYESHNSYTCEVTHKTSTSPVVKSFNRGECSRGGLEVLFQ |
Antigen
Chain: C
Mutation: NULL
| >4YUE_C|Chain C|Interleukin-2|Mus musculus (10090) GPGSHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQAAA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR36 ARG53 VAL102 PHE104 TYR105 TYR106 SER107 ARG108 ARG111 TRP112 L: ASP31 GLY33 ASN34 TYR35 THR55 GLY67 SER68 ARG69 SER70 GLY71 TYR95 TYR99 C: ARG52 THR55 PHE56 LYS57 TYR59 GLN71 GLU74 ASP75 GLU76 LEU77 GLY78 PRO79 HIS82 ARG105 VAL109 LYS112 THR117 PHE118 GLU119 PHE122 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
