Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1120 |
| PDBID: | 4YK4 |
| Chains: | ZY_E |
| Organism: | Homo sapiens, Influenza A virus (A/Solomon Islands/3/2006(H1N1)) |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1016/j.cell.2015.04.028 |
| Antibody | |
| Antibody: | 641 I-9 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >4YK4_Z|Chain B[auth C], E[auth Z]|641 I-9 VHCH antibody|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWSWIRQPPGKGLEWIGYIYYSGSTDYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARRRSDFETVDFIYHYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: Y
Mutation: NULL
| >4YK4_Y|Chain A[auth B], D[auth Y]|641 I-9 VLCL antibody|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSIPLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >4YK4_E|Chain C[auth A], F[auth E]|Hemagglutinin|Influenza A virus (464623) ADPGYLLEAPLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSGLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Z: SER30 SER31 TYR32 TYR33 TYR50 TYR52 TYR53 SER54 SER56 ASP58 SER100 PHE102 THR104 VAL105 ASP106 ILE108 HIS110 E: THR131 GLY134 VAL135 SER136 ALA137 SER145 TRP153 THR155 GLY156 GLY159 LEU160 GLY189 ASP190 ARG192 ALA193 LEU194 HIS196 THR197 GLU198 GLN226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
