Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1119 |
| PDBID: | 4YJZ |
| Chains: | L_E |
| Organism: | Influenza A virus (A/Solomon Islands/3/2006(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.72 |
| Reference: | 10.1016/j.cell.2015.04.028 |
| Antibody | |
| Antibody: | H2526 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: L
Mutation: NULL
| >4YJZ_L|Chain B[auth L]|scFv H2526|Homo sapiens (9606) QSVLTQPLSAPGTPGQRVTISCSGSSSNVGTNAVDWYQRLPGTAPKLLIYYNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCATWDNSLNDRVFGGGTKLTVLGGGGGGSGGGGSGGGGSQVQLVQSGAEVRKPGSSVKVSCKASRGTFSNHAVSWVRQAPGHGLEWLGGLIPIFSTPHYAQKFQGRVTITADESTNTVHMELSSLRSEDTAVYYCAREIPGATSGPDHFFFYGMDVWGQGTTVAVSSASGSSGSGHHHHHH |
Antigen
Chain: E
Mutation: NULL
| >4YJZ_E|Chain A[auth E]|Hemagglutinin|Influenza A virus (464623) APLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSGLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER26 GLY30 THR31 TYR51 LYS67 ASN94 SER95 ASN97 SER230 ASN231 ILE252 PRO253 ILE254 PHE255 THR257 PRO258 GLN265 GLY302 ALA303 THR304 SER305 GLY306 PRO307 ASP308 HIS309 PHE310 TYR313 E: TYR95 THR131 THR133 GLY134 VAL135 SER136 ALA137 SER138 SER140 GLY143 GLU144 SER145 TRP153 THR155 GLY156 LYS157 ASN158 GLY159 HIS183 PRO186 ASN187 GLY189 ASP190 ARG192 ALA193 LEU194 HIS196 LYS222 ARG224 ASP225 GLN226 GLU227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
