Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1113 |
| PDBID: | 4YFL |
| Chains: | HL_G |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.39 |
| Reference: | 10.1016/j.cell.2015.05.007 |
| Antibody | |
| Antibody: | 1B2530 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 clade A/E 93TH057 gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4YFL_H|Chain B[auth F], E[auth H]|1B2530 heavy chain|Homo sapiens (9606) QVQLEQSGTAVRKPGASVTLSCQASGYNFVKYIIHWVRQKPGLGFEWVGMIDPYRGRPWSAHKFQGRLSLSRDTSMEILYMTLTSLKSDDTATYFCARAEAASDSHSRPIMFDHWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS |
Light Chain: L
Mutation: NULL
| >4YFL_L|Chain C[auth I], F[auth L]|1B2530 Light chain|Homo sapiens (9606) QSALTQPPSASGAPGQRVTISCSGGPSNVGGNYVYWYRQFPGTAPTLLILRDDQRPSGVPDRFSASKSGNSASLAISGLRPDDEGFYFCATYDSDGSIRLFGGGTALTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTEC |
Antigen
Chain: G
Mutation: NULL
| >4YFL_G|Chain A[auth E], D[auth G]|Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160|Human immunodeficiency virus 1 (11676) VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSNGGSGSGGDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHHFNCRGEFFYCNTTQLFNNTCIGNETMKGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ILE33 TRP47 MET50 TYR54 ARG55 GLY56 ARG57 PRO58 TRP59 SER60 ALA61 HIS62 LYS63 GLN65 LEU68 LEU70 ARG72 THR74 SER75 MET76 ALA101 ALA102 SER103 HIS106 ARG108 L: GLN1 SER2 SER93 ASP94 ILE95 LEU97 G: LYS97 GLY124 THR257 GLN258 GLU275 ASN276 THR278 ASN279 ASN280 ALA281 LYS282 LYS357 GLN362 PRO364 SER365 GLY366 GLY367 ASP368 ILE371 THR372 TRP427 GLY429 THR455 ARG456 ASP457 GLY458 GLY459 ALA460 ASN461 ASN462 THR463 GLU466 THR467 ARG469 PRO470 GLY471 GLY472 GLY473 ASN474 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
