Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1112 |
| PDBID: | 4YE4 |
| Chains: | HL_G |
| Organism: | Human immunodeficiency virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.72 |
| Reference: | 10.1016/j.cell.2015.05.007 |
| Antibody | |
| Antibody: | HJ16 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 HT593.1 gp120 |
| Antigen mutation: | No |
| Durg Target: | P35961 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4YE4_H|Chain B[auth H]|Heavy chain human antibody HJ16|Homo sapiens (9606) QMKLMQSGGVMVRPGESATLSCVASGFDFSRNGFEWLRQGPGKGLQWLATVTFESKTHVTASARGRFTISRDNSRRTVYLQMTNLQPDDTAMYFCVKDQTIFHKNGAVDFFSYFDLWGRGAPVIVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK |
Light Chain: L
Mutation: NULL
| >4YE4_L|Chain C[auth L]|Light chain of HJ16|Homo sapiens (9606) DVVMTQSPEFLAVSLGERATLECKSSHSLLYAPYDKDALVWYQQKPGQPPKLLLDWASSRRSGVSDRFSATSASGRYFTLTISNFRADDVATYYCQQTRWTPPTFGGGTKVDLNRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR |
Antigen
Chain: G
Mutation: NULL
| >4YE4_G|Chain A[auth G]|HT593.1 gp120|Human immunodeficiency virus (12721) VWKEATTTLFCASDAKAYETEVHNVWATHACVPTDPNPQEVLLENVTENFNMWKNNMVEQMQEDIISLWDQSLKPCVKLTGGSVITQACPKVSFEPIPIHYCTPAGFAILKCNDRNFNGTGPCKNVSTVQCTHGIKPVVSTQLLLNGSLAEAEVVIRSENFTNNAKTIIIQLNETVEINCTRPNNGGSGSGGNIRQAHCNISRATWNSTLKKIVAKLREQFGNKTIVFQPSSGGDPEIVMHSFNCGGEFFYCNTTQLFNSTWNSTEESNSTEEGTITLPCRIKQIINMWQEVGKAMYAPPIEGQIRCSSNITGLLLTRDGGNNNKTNGTEIFRPGGGDMRDNWRSELYKYKVVKIE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ARG31 PHE53 GLU54 LYS56 PHE102 HIS103 LYS104 ASN105 GLY106 ALA107 VAL108 ASP109 PHE110 PHE111 SER112 L: VAL2 HIS27 TYR31 ALA32 PRO33 THR98 ARG99 TRP100 THR101 PRO102 PRO103 G: THR278 ASN279 ASN280 ALA281 THR283 VAL360 GLN362 PRO363 SER365 GLY366 ILE371 THR455 ARG456 ASP457 GLY458 GLY459 ASN460 ASN461 ASN462 LYS463 ILE469 ARG471 PRO472 GLY473 GLY474 ASP476 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
