Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 11 |
| PDBID: | 1BVK |
| Chains: | BA_C |
| Organism: | Homo sapiens, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1084/jem.187.4.479 |
| Antibody | |
| Antibody: | HULYS11 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1BVK_B|Chain B, E|HULYS11|Homo sapiens (9606) QVQLQESGPGLVRPSQTLSLTCTVSGFSLTGYGVNWVRQPPGRGLEWIGMIWGDGNTDYNSALKSRVTMLKDTSKNQFSLRLSSVTAADTAVYYCARERDYRLDYWGQGSLVTVSSG |
Light Chain: A
Mutation: NULL
| >1BVK_A|Chain A, D|HULYS11|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASGNIHNYLAWYQQKPGKAPKLLIYYTTTLADGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQHFWSTPRTFGQGTKVEIKR |
Antigen
Chain: C
Mutation: NULL
| >1BVK_C|Chain C, F|LYSOZYME|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: HIS30 TYR32 TYR49 TYR50 THR53 PHE91 TRP92 SER93 B: SER28 THR30 GLY31 TYR32 GLY33 TRP52 GLY53 ASP54 ARG99 ASP100 TYR101 ARG102 C: ASP18 ASN19 ARG21 GLY22 TYR23 SER24 ASN27 GLY102 ASN103 LYS116 GLY117 THR118 ASP119 VAL120 GLN121 ILE124 ARG125 GLY126 CYS127 LEU129 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
