Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1071 |
| PDBID: | 4XVS |
| Chains: | HL_G |
| Organism: | Homo sapiens, Human immunodeficiency virus 1 |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.cell.2015.03.004 |
| Antibody | |
| Antibody: | VRC07_1995 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 Donor 45 01dG5 coreE gp120 |
| Antigen mutation: | No |
| Durg Target: | P35961 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4XVS_H|Chain A[auth H]|VRC07_1995 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 Heavy chain|Homo sapiens (9606) QVQLLQSGAQVKKTGASMRISCKTSGYTFLNCPINWVRQAPGRGLEWMGWMKPRGGAVNYPQKFQGRVTMTRDMSTDTAFLDMSNLRSDDTAVYFCARGKYCTASDYYNWDFEHWGRGTLVTVSSPATKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >4XVS_L|Chain B[auth L]|45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 Light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRTSQYGSLAWYQQRPGQAPRLVIYGGSSRATGIPDRFTGSRSGADYTLTINRLEPEDFGIYYCQQYEFFGQGTKVEVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLASPVTKSFNRGEC |
Antigen
Chain: G
Mutation: NULL
| >4XVS_G|Chain C[auth G]|Donor 45 01dG5 coreE gp120|Human immunodeficiency virus 1 (11676) VWKEATATLFCASDAKAYETEVHNVWATHACVPTDPNPQEVVLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTGGSVITQACPKISFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEIVIRSENIKDNAKIIIVQLNETVEINCTRPNNGGSGSGGDIRQAHCNISKAKWENTLKQIARKLREHFKNETIAFNQSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWTWNDTEVVNNTEKNINITLPCRIKQIINMWQEVGKAMYAPPIKGQIRCSSNITGLLLTRDGGSSTNGTTETFRPGGGDMRDNWRSELYKYKVVKIEGSLEVLFQGPGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: LEU30 PRO33 TRP47 TRP50 LYS52 ARG54 GLY55 GLY56 ALA57 VAL58 ASN59 TYR60 PRO61 GLN62 LYS63 GLN65 ARG72 MET74 TYR101 ALA104 SER105 ASP106 TYR107 TYR108 ASN109 TRP110 L: GLU3 TYR30 TYR91 GLU96 PHE97 G: TRP96 LYS97 GLU102 GLU275 ASN276 LYS278 ASP279 ASN280 ALA281 LYS282 ILE283 SER365 GLY366 GLY367 ASP368 ILE371 VAL430 THR455 ARG456 ASP457 GLY458 GLY459 SER460 SER461 THR462 GLU467 ARG470 GLY472 GLY473 GLY474 ASP475 ARG477 ARG481 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
