Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1046 |
| PDBID: | 4XI5 |
| Chains: | DC_B |
| Organism: | Human herpesvirus 3 strain Oka vaccine, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.90 |
| Reference: | 10.1073/pnas.1501176112 |
| Antibody | |
| Antibody: | 94 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Varicella-zoster virus envelope glycoprotein L |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >4XI5_D|Chain D|Fab-94 heavy chain|Homo sapiens (9606) MEFGLSWVFLVAILEGVHCEVQLVESGGGVVQPGRSLRLSCGASGFTFNTYAMHWVRQAPGKGVEWVAVVSDGGGNRYYAASVKGRFTISRDNSKNTLFLQLNTLRPEDTAVYYCARSRGNHYYYGMDVWGRGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGSENLYFQGSWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Light Chain: C
Mutation: NULL
| >4XI5_C|Chain C|Fab-94 light chain|Homo sapiens (9606) DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANNFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >4XI5_B|Chain B|Envelope glycoprotein L|Human herpesvirus 3 strain Oka vaccine (341980) LHLQDDTPLFFGAKPLSDVSLIITEPCVSSVYEAWDYAAPPVSNLSEALSGIVVKTKCPVPEVILWFKDKQMAYWTNPYVTLKGLTQSVGEEHKSGDIRDALLDALSGVWVDSTPSSTNIPENGCVWGADRLFQRVCQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: ILE2 GLN27 ASN93 PHE94 PRO95 D: SER52 ASP53 GLY55 GLY56 ASN57 ARG58 TYR59 TYR60 B: GLY112 GLU114 ARG121 ASP122 LEU125 ASP126 SER129 GLY130 VAL133 ASP134 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
