Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1041 |
| PDBID: | 4XHJ |
| Chains: | DC_A |
| Organism: | Human herpesvirus 3 strain Oka vaccine, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.16 |
| Reference: | 10.1073/pnas.1501176112 |
| Antibody | |
| Antibody: | RC Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Varicella-zoster virus envelope glycoprotein H |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >4XHJ_D|Chain D, H|Fab-RC heavy chain|Homo sapiens (9606) MEFGLSWVFLVAILEGVHCQVQLVQSGAEMKKPGASVKVSCKASGYTFIGYHLHWVRQAPGQGLEWMGWINPNSGETNYAQKFQDWVTMTRDTSINTAYMELRLRSDDTAVYYCARGGMTMVRGVMMDWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGSENLYFQGSWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Light Chain: C
Mutation: NULL
| >4XHJ_C|Chain C, G|Fab-RC light chain|Homo sapiens (9606) DIQMTQSPSFLSASVGDRVTITCRASQGLDNFLAWYQQKPGKAPKLLIYAASTLQRGVPSRFGGSGSGTEFTLTISSLQPEDFATYYCQQLNSYSLTFGPGTKVEIKRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >4XHJ_A|Chain A, E|Envelope glycoprotein H|Human herpesvirus 3 strain Oka vaccine (341980) MFALVLAVVILPLWTTANKSYVTPTPATRSIGHMSALLREYSDRNMSLKLEAFYPTGFDEELIKSLHWGNDRKHVFLVIVKVNPTTHEGDVGLVIFPKYLLSPYHFKAEHRAPFPAGRFGFLSHPVTPDVSFFDSSFAPYLTTQHLVAFTTFPPNPLVWHLERAETAATAERPFGVSLLPARPTVPKNTILEHKAHFATWDALARHTFFSAEAIITNSTLRIHVPLFGSVWPIRYWATGSVLLTSDSGRVEVNIGVGFMSSLISLSSGLPIELIVVPHTVKLNAVTSDTTWFQLNPPGPDPGPSYRVYLLGRGLDMNFSKHATVDICAYPEESLDYRYHLSMAHTEALRMTTKADQHDINEESYYHIAARIATSIFALSEMGRTTEYFLLDEIVDVQYQLKFLNYILMRIGAGAHPNTISGTSDLIFADPSQLHDELSLLFGQVKPANVDYFISYDEARDQLKTAYALSRGQDHVNALSLARRVIMSIYKGLLVKQNLNATERQALFFASMILLNFREGLENSSRVLDGRTTLLLMTSMCTAAHATQAALNIQEGLAYLNPSKHMFTIPNVYSPCMGSLRTDLTEEIHVMNLLSAIPTRPGLNEVLHTQLDESEIFDAAFKTMMIFTTWTAKDLHILHTHVPEVFTCQDAAARNGEYVLILPAVQGHSYVITRNKPQRGLVYSLADVDVYNPISVVYLSKDTCVSEHGVIETVALPHPDNLKECLYCGSVFLRYLTTGAIMDIIIIDSKDTERQLAAMGNSTIPPFNPDMHGDDSKAVLLFPNGTVVTLLGFERRGSENLYFQGSWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: ASP30 ASN31 PHE32 TYR49 ALA50 THR53 ARG56 LEU91 ASN92 SER93 TYR94 D: TRP50 GLY99 MET100 THR101 MET102 VAL103 ARG104 VAL106 MET108 A: LEU146 THR150 PHE152 PRO153 PRO154 ASN155 PRO156 LEU157 VAL158 TRP159 LYS281 THR286 SER287 ASP288 THR290 TRP291 PHE292 GLN293 LEU294 ASN295 ARG306 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
