Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1035 |
| PDBID: | 4X7E |
| Chains: | C_A |
| Organism: | Norovirus, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 2.11 |
| Reference: | 10.1128/JVI.03176-14 |
| Antibody | |
| Antibody: | Nano-85 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Capsid protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >4X7E_C|Chain B[auth C], D|Nano-85 Nanobody|Vicugna pacos (30538) DVQLVESGGGLVQPGGSLRLSCAASGSIFSIYAMGWYRQAPGKQRELVASISSGGGTNYADSVKGRFTISGDNAKNTVYLQMNSLKPEDTAVYYCKREDYSAYAPPSGSRGRGTQVTVSSHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >4X7E_A|Chain A, C[auth B]|Capsid protein|Norovirus (142786) SKPFTLPILTLGELTNSRFPLPIDVLYTNPNESAIVQCQNGRCTLDGELQGTTQLLPTGICAFRGKVTQQVQDEHRGTHWNMTVTNLNGTPFDPTEDVPAPLGTPDFSGQIYGVISQRNTNTVPGEGNLPANRAHEAVIATYSPKFTPKLGNIQFSTWETQDVSSGQPTKFTPVGLASVDANSHFDQWTLPSYSGALTLNMNLAPSVAPVFPGECLLFFRSFIPLKGGYGNPAIDCLMPQEWVQHLYQESAPSLSDVALVRYVNPETGRTLFEAKLHRNGFLTVARNSAGPVVAPTNGYFRFDSWVNQFYTLAPM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ILE31 TYR32 ALA33 GLY35 TYR37 LEU47 SER50 SER52 SER53 GLY54 GLY55 GLY56 THR57 ASN58 LYS96 GLU98 TYR100 SER101 ALA102 TYR103 ALA104 PRO105 PRO106 A: PRO226 PHE227 PHE434 LEU477 SER478 LEU482 ARG484 GLU496 PHE525 ASP526 SER527 TRP528 VAL529 ASN530 PHE532 TYR533 THR534 LEU535 ALA536 PRO537 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
