Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1029 |
| PDBID: | 4WV1 |
| Chains: | BA_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.36 |
| Reference: | 10.1158/1535-7163.MCT-14-1050 |
| Antibody | |
| Antibody: | 2B.1.3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Fibroblast growth factor receptor 2 |
| Antigen mutation: | No |
| Durg Target: | P21802 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >4WV1_B|Chain C[auth B], D[auth E]|Fab heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFTSTGISWVRQAPGKGLEWVGRTHLGDGSTNYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARTYGIYDLYVDYTEYVMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: A
Mutation: NULL
| >4WV1_A|Chain E[auth A], F[auth D]|Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDVDTSLAWYKQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSTGHPQTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >4WV1_C|Chain A[auth C], B[auth F]|Fibroblast growth factor receptor 2|Homo sapiens (9606) APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVER |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: THR30 SER31 THR32 LEU52 GLY53 ASP54 GLY55 TYR96 GLY97 ILE98 TYR99 A: ASP30 THR31 TYR49 SER52 PHE53 LEU54 GLY66 SER67 C: ASN155 LYS158 MET159 LYS161 LEU163 HIS164 ALA165 VAL166 PRO167 ALA168 ALA169 ASN170 THR171 VAL172 LYS173 PHE174 ARG175 PRO177 LYS205 ARG207 HIS210 ILE214 GLU216 TYR241 VAL246 ARG248 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
