Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1013 |
| PDBID: | 4W2Q |
| Chains: | G_H |
| Organism: | Lama glama, Marburg virus - Musoke, Kenya, 1980 |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.3389/fimmu.2017.01234 |
| Antibody | |
| Antibody: | C VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Marburg virus (MARV) Nucleoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: G
Mutation: NULL
| >4W2Q_G|Chain A, C, E, G|Anti-Marburgvirus Nucleoprotein Single Domain Antibody C|Lama glama (9844) KVQLQESGGGLVQVGGSLRLSCKASGFTFRSSAMGWYRRAPGKQRELVASLTTTGTADYGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHEDPYGMESLRYWGQGTQVTVSS |
Antigen
Chain: H
Mutation: NULL
| >4W2Q_H|Chain B, D, F, H|Nucleoprotein|Lake Victoria marburgvirus (33727) MGHHHHHHGGGSWPQRVVTKKGRTFLYPNDLLQTNPPESLITALVEEYQNPVSAKELQADWPDMSFDERRHVAMNL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: LYS1 VAL2 GLY26 PHE27 PHE29 ARG30 SER31 PRO99 TYR100 MET102 SER104 LEU105 ARG106 TYR107 H: LYS640 LEU663 TYR667 ASN669 SER672 LYS674 GLU675 LEU676 ALA678 ASP679 ASP682 MET683 SER684 ASP686 GLU687 HIS690 VAL691 ASN694 LEU695 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
