Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 100 |
| PDBID: | 1MLC |
| Chains: | DC_F |
| Organism: | Mus musculus, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1016/0022-2836(94)90046-9 |
| Antibody | |
| Antibody: | D44.1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >1MLC_D|Chain B, D|IGG1-KAPPA D44.1 FAB (HEAVY CHAIN)|Mus musculus (10090) QVQLQESGAEVMKPGASVKISCKATGYTFSTYWIEWVKQRPGHGLEWIGEILPGSGSTYYNEKFKGKATFTADTSSNTAYMQLSSLTSEDSAVYYCARGDGNYGYWGQGTTLTVSSASTTPPSVFPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: C
Mutation: NULL
| >1MLC_C|Chain A, C|IGG1-KAPPA D44.1 FAB (LIGHT CHAIN)|Mus musculus (10090) DIELTQSPATLSVTPGDSVSLSCRASQSISNNLHWYQQKSHESPRLLIKYVSQSSSGIPSRFSGSGSGTDFTLSINSVETEDFGMYFCQQSNSWPRTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: F
Mutation: NULL
| >1MLC_F|Chain E, F|HEN EGG WHITE LYSOZYME|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ASN31 ASN32 TYR50 SER91 ASN92 SER93 TRP94 ARG96 D: SER30 THR31 TYR32 TRP33 GLU35 GLU50 LEU52 SER55 GLY56 SER57 THR58 TYR59 GLY99 ASP100 GLY101 F: GLN41 THR43 ARG45 ASN46 THR47 ASP48 GLY49 SER50 THR51 TYR53 ASN65 ASP66 GLY67 ARG68 PRO70 PRO79 SER81 LEU84 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
