Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1 |
| PDBID: | 1A14 |
| Chains: | HL_N |
| Organism: | Influenza A virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1006/jmbi.1998.1794 |
| Antibody | |
| Antibody: | NC10 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | NEURAMINIDASE |
| Antigen mutation: | No |
| Durg Target: | P03472 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1A14_H|Chain B[auth H]|NC10 FV (HEAVY CHAIN)|Mus musculus (10090) QVQLQQSGAELVKPGASVRMSCKASGYTFTNYNMYWVKQSPGQGLEWIGIFYPGNGDTSYNQKFKDKATLTADKSSNTAYMQLSSLTSEDSAVYYCARSGGSYRYDGGFDYWGQGTTVTV |
Light Chain: L
Mutation: NULL
| >1A14_L|Chain C[auth L]|NC10 FV (LIGHT CHAIN)|Mus musculus (10090) DIELTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQNPDGTVKLLIYYTSNLHSEVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQDFTLPFTFGGGTAA |
Antigen
Chain: N
Mutation: NULL
| >1A14_N|Chain A[auth N]|NEURAMINIDASE|Influenza A virus (11320) RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSCYGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPNALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY53 ASN54 GLY55 ASP56 THR57 SER58 TYR99 L: ASP1 GLN27 ASP28 SER30 ASN31 TYR32 TYR50 ASP91 PHE92 THR93 LEU94 N: PRO328 ASN329 ASP330 PRO331 THR332 TYR341 PRO342 GLY343 ASN344 ASN345 ILE366 SER367 ILE368 ALA369 SER370 SER372 ASN400 THR401 TRP403 LYS432 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
