Welcome

Welcome to AGODB

AGODB is a comprehensive domain annotation database of argonaute (Ago) proteins, which contains extensive information about 1902 Ago proteins manually extracted from research articles and public databases.

Introduction

Argonaute (Ago) proteins are widely expressed in almost all organisms. Eukaryotic Ago (eAgo) proteins play a critical role in the biogenesis of small RNAs and prokaryotic Ago (pAgo) proteins defend against invading nucleic acids via binding small RNA or DNA. Protein domains are fundamental units of protein structure, function, and evolution, whereas the domains of Ago proteins are not well annotated/curated currently. Therefore, a comprehensive domain annotation database of Ago proteins is lacking, and it is not conducive for researchers to understand the function and mechanism of argonaute proteins. Herein, we constructed the first online resource (AGODB), a comprehensive domain annotation database of Ago proteins. AGODB curates domain annotation, specially for long pAgos, all six domains are annotated/curated. The database also allows users to search the database with a variety of options and download the search results.

We believe that the AGODB will be a useful resource for understanding the function and domain components of Ago proteins.

Statistics

Eukaryotic Ago protein entries：1095
Prokaryotic Ago protein entries：807