What may phage display common sequence stand for
Though (consensus) sequence of mimotopes might be a subsequence of its natural protein, it is more often a linear sequence mimicking spatial neighbor clusters of natural protein. Though residues of such a cluster usually are discontinuous or even very far away at the primary structure level, they are brought together by the folding of the protein into its native structure. Thus, a cluster of spatial neighbors is a kind of structural unit. And it is of important function when bound to its receptor or ligand, antibody or antigen, enzyme or substrate. Now, let's find out all candidate spatial neighbor clusters that a (consensus) sequence of mimotopes might stand for...Click here to get some test data!
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