101 3LNZ A-B:1, C-D:2, E-F:3, I-J:4, M-N:5, O-P:6, A-N:11, B-G:12, E-H:15, F-G:16, G-H:17, K-L:18, [A-B]>A: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+V93+H96+Y100 [C-D]>C: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+Y100 [E-F]>E: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+V93+H96+IY(99,100) [I-J]>I: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+Y100 [M-N]>M: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+IY(99,100) [O-P]>O: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+IY(99,100) [A-N]>A: P89 [B-G]>G: P89 [E-H]>E: FY(55,56)+Q59 [F-G]>G: E52+FY(55,56)+Q59 [G-H]>G: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+IY(99,100) [K-L]>K: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+V93+H96+Y100 [A-B]>B: TSF(1-3)+YWLL(6,7,9,10) [C-D]>D: TSF(1-3)+YW(6,7)+L10 [E-F]>F: TSF(1-3)+YWLLS(6,7,9-11) [I-J]>J: TSFAYWLLS(1-4,6,7,9-11) [M-N]>N: TSF(1-3)+YWLLS(6,7,9-11) [O-P]>P: SF(2,3)+YWLL(6,7,9,10) [A-N]>N: L10 [B-G]>B: L10 [E-H]>H: SFAE(2-5)+A8 [F-G]>F: TSFAE(1-5)+A8 [G-H]>H: TSF(1-3)+YWLLSP(6,7,9-12) [K-L]>L: TSF(1-3)+YWLLSP(6,7,9-12) 102 3G03 A-B:1, C-D:2 [A-B]>A: L54+LG(57,58)+IM(61,62)+Y67+QH(72,73)+VKH(93,94,96)+Y100 [C-D]>C: K51+L54+LG(57,58)+IM(61,62)+Y67+QH(72,73)+VKH(93,94,96)+Y100 [A-B]>B: LTFEYW(17-20,22,23)+L26 [C-D]>D: TFEYWQLT(18-20,22,23,25-27) 103 3JZR A-P:1 [A-P]>A: GS(16,17)+Q24+L54+LGQIM(57-59,61,62)+Y67+QH(72,73)+VKH(93,94,96)+I99 [A-P]>P: LTFEWWQLTS(17-20,22,23,25-28) 104 3JZS A-P:1 [A-P]>A: K51+LFLG(54,55,57,58)+IM(61,62)+Y67+QH(72,73)+VK(93,94)+H96 [A-P]>P: ETFEWW(1-4,6,7)+LL(10,11) 105 3DAB A-B:1, C-D:3, E-F:6, F-G:8, G-H:9 [A-B]>A: VK(49,50)+M53+G57+IM(60,61)+QH(71,72)+V92+P95+LY(98,99) [C-D]>C: M53+LG(56,57)+I60+Y66+QH(71,72)+V92+P95+LY(98,99) [E-F]>E: M53+G57+I60+Y66+QEQH(69-72)+VKP(92,93,95)+LY(98,99) [F-G]>G: G78+E83 [G-H]>G: VK(49,50)+M53+LG(56,57)+IM(60,61)+Y66+QHV(71,72,74)+V92+P95+LY(98,99) [A-B]>B: ETFLW(17-19,22,23)+LPE(26-28) [C-D]>D: ETF(17-19)+LW(22,23)+LP(26,27) [E-F]>F: QETF(16-19)+LW(22,23)+LP(26,27) [F-G]>F: TFS(18-20) [G-H]>H: FESLW(18-20,22,23)+LPE(26-28) 106 3EQY A-C:2, B-D:3, B-C:4 [A-C]>A: V49+M53+LG(56,57)+IM(60,61)+Y66+QH(71,72)+V92+P95+Y99 [B-D]>B: V49+M53+LG(56,57)+IM(60,61)+Y66+QH(71,72)+V92+P95+Y99 [B-C]>B: AA(69,70) [A-C]>C: TSF(1-3)+YW(6,7)+LSP(10-12) [B-D]>D: TSF(1-3)+YW(6,7)+LSP(10-12) [B-C]>C: A4+N8 107 3FDO A-B:1 [A-B]>A: M53+LG(56,57)+IM(60,61)+Y66+QH(71,72)+VK(92,93)+LY(98,99) [A-B]>B: LTF(17-19)+YW(22,23)+LT(26,27) 108 3JZO A-P:1 [A-P]>A: K50+M53+LG(56,57)+IM(60,61)+Y66+QHV(71,72,74)+VK(92,93)+LY(98,99) [A-P]>P: LTFEYW(1-4,6,7)+LTS(10-11) 109 3JZP A-P:1 [A-P]>A: K50+M53+G57+IM(60,61)+Y66+QHV(71,72,74)+VK(92,93)+LY(98,99) [A-P]>P: LTFEWW(17-20,22,23)+LTS(26-28) 110 3JZQ A-P:2, B-Q:3 [A-P]>A: K50+M53+LG(56,57)+IM(60,61)+Y66+QH(71,72)+VKP(92,93,95)+LY(98,99) [B-Q]>B: VK(49,50)+M53+G57+I60+Y66+QH(71,72)+VK(92,93)+P95+LY(98,99) [A-P]>P: ETF(1-3)+WW(6,7)+LL(10,11) [B-Q]>Q: ETF(1-3)+WW(6,7)+LLS(10-12) 111 1G9M G-H:2, G-L:3 [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) [G-H]>H: I52+LVH(55,57,59)+E103+EGEYR(106-110) [G-L]>L: WP(94,95) 112 1G9N G-H:2, G-L:3 [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) [G-H]>H: LVH(55,57,59)+E103+EGEYR(106-110) [G-L]>L: WP(94,95) 113 1GC1 G-H:2, G-L:3 [G-H]>G: K121+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203)+M434 [G-H]>H: LVH(55,57,59)+E103+EGEYDN(106-111) [G-L]>L: WP(94,95) 114 1RZJ G-H:2, G-L:3 [G-H]>G: VL(120,122)+T202+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) [G-H]>H: LVH(54,56,58)+E99+EGEYDN(100B-110G) [G-L]>L: WP(94,95) 115 1RZK G-H:2, G-L:3 [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+P437 [G-L]>G: C119+TQ(202,203) [G-H]>H: LVH(54,56,58)+E99+EGEYD(100B-110F) [G-L]>L: WP(94,95) 116 2NXY A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+P437 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) 117 2NXZ A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) 118 2NY0 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) 119 2NY1 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) 120 2NY2 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 [A-C]>C: W2094 [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) 121 2NY3 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [A-C]>C: W2094 [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) 122 2NY4 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+ILVH(3054,3055,3057,3059)+E3103+EGEYDN(3106-3111) 123 2NY5 G-H:2, G-L:3 [G-H]>G: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: CV(119,120)+TQC(202,203,205) [G-H]>H: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) [G-L]>L: WP(2094,2095) 124 2C9F A-S, A-T, A-W, B-S, B-T, C-T, C-U, D-U, D-V, E-V, E-W [A-S]>A: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-T]>A: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-W]>A: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [B-S]>B: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [B-T]>B: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [C-T]>C: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [C-U]>C: R197+E203+K385+LTH(490-492)+NRFPE(495-499) [D-U]>D: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [D-V]>D: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [E-V]>E: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [E-W]>E: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-S]>S: FNPVYPYDT(11-19) [A-T]>T: FNPVYPYDT(11-19) [A-W]>W: TFNPYYD(10-13,15,17,18) [B-S]>S: TFNPYYD(10-13,15,17,18) [B-T]>T: FNPVYPYDT(11-19) [C-T]>T: TFNPYYD(10-13,15,17,18) [C-U]>U: FNPVYPYDT(11-19) [D-U]>U: TFNPYYD(10-13,15,17,18) [D-V]>V: FNPVYPYDT(11-19) [E-V]>V: TFPYYD(10,11,13,15,17,18) [E-W]>W: FNPVYPYDT(11-19) The site residues were obtained through computing contacts by a distance ≤ 4Å. 125 2C9F A-S, A-T, A-W, B-S, B-T, C-T, C-U, D-U, D-V, E-V, E-W [A-S]>S: FNPVYPYDT(11-19) [A-T]>T: FNPVYPYDT(11-19) [A-W]>W: TFNPYYD(10-13,15,17,18) [B-S]>S: TFNPYYD(10-13,15,17,18) [B-T]>T: FNPVYPYDT(11-19) [C-T]>T: TFNPYYD(10-13,15,17,18) [C-U]>U: FNPVYPYDT(11-19) [D-U]>U: TFNPYYD(10-13,15,17,18) [D-V]>V: FNPVYPYDT(11-19) [E-V]>V: TFPYYD(10,11,13,15,17,18) [E-W]>W: FNPVYPYDT(11-19) [A-S]>A: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-T]>A: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-W]>A: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [B-S]>B: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [B-T]>B: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [C-T]>C: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [C-U]>C: R197+E203+K385+LTH(490-492)+NRFPE(495-499) [D-U]>D: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [D-V]>D: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [E-V]>E: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [E-W]>E: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) The site residues were obtained through computing contacts by a distance ≤ 4Å.