26 1DU3 A-D:1, C-F:2, H-K:3, I-L:4, A-F:5, C-E:6, H-J:7, I-K:8, B-D:9, G-L:10, B-E:11, G-J:12, C-L:13 [A-D]>A: E36+Y50+LF(58,59)+LRCTRCD(61-67)+E70+C84+R92+EMC(98-100)+K102 [C-F]>C: Y50+F59+LRCTR(61-65)+D67+E70+N81+C84+EMC(98-100)+K102 [H-K]>H: Y50+F59+LRCTRCD(61-67)+E70+N81+C84+R92+EMC(98-100)+K102 [I-L]>I: Y50+F59+LRCTR(61-65)+D67+E70+N81+C84+EM(98,99)+K102 [A-F]>A: THND(52,53,55,56)+F91+EDSPEM(94-99)+RK(101,102)+D122 [C-E]>C: TH(52,53)+NDL(55-57)+L61+F91+EDSPEM(94-99)+RK(101,102)+D122 [H-J]>H: THND(52,53,55,56)+L61+F91+EDSPEM(94-99)+RK(101,102) [I-K]>I: THND(52,53,55,56)+EDSPEM(94-99)+RK(101,102) [B-D]>B: TH(52,53)+D56+L61+EDSPEM(94-99)+RKR(101,102,104)+CP(107,108)+M111 [G-L]>G: TH(52,53)+NDL(55-57)+L61+EDSPEM(94-99)+RKR(101,102,104)+P108+M111+D122+C125 [B-E]>B: Y50+F59+LRCTRCD(61-67)+E70+N81+C84+R92+EMC(98-100) [G-J]>G: Y50+LF(58,59)+RCTRCD(62-67)+E70+N81+C84+R92+EMCRK(98-102) [C-L]>C: YG(46,47)+EL(72,73)+PCT(75-77)+TR(79,80) [A-D]>D: TRGRSN(129-134)+E155+RSG(158-160)+YRQ(189,191,193)+EYL(236,237,239) [C-F]>F: GTRGRSNT(128-135)+E155+RSH(158,159,161)+YRQE(189,191,193,195)+EYL(236,237,239)+H270 [H-K]>K: RGRSNT(130-135)+RSG(158-160)+YRQ(189,191,193)+EYL(236,237,239) [I-L]>L: RGRSNT(130-135)+RSGH(158-161)+YR(189,191)+E236+L239 [A-F]>F: LR(147,149)+KDQVY(201,203,205,207,209)+SYPD(215-218)+K224+TD(261,262) [C-E]>E: LR(147,149)+KDQ(201,203,205)+Y209+SYPD(215-218)+K224+TD(261,262) [H-J]>J: LR(147,149)+KDQVY(201,203,205,207,209)+SYPD(215-218)+K224+TD(261,262) [I-K]>K: LR(147,149)+KDQVY(201,203,205,207,209)+SYPD(215-218)+K224+TD(261,262) [B-D]>D: LR(147,149)+NTK(199-201)+DQ(203,205)+Y209+SYPD(215-218)+K224+TD(261,262) [G-L]>L: LR(147,149)+EN(198,199)+KDQVY(201,203,205,207,209)+SYPD(215-218)+K224+TN(261,262) [B-E]>E: RGRSNT(130-135)+RS(158,159)+Y189+RFQ(191-193)+YL(237,239) [G-J]>J: TRGRSNT(129-135)+RSG(158-160)+YRQ(189,191,193)+EYL(236,237,239) [C-L]>L: HRN(168,170,171)+H177+NR(253,255) 27 1DKD A-E:2, B-F:3, D-H:4, C-G:6 [A-E]>A: R231+LE(237,238)+A241+T261+N265+RIV(268,270,271) [B-F]>B: R231+L234+LE(237,238)+A241+T261+N265+RIV(268,270,271) [D-H]>D: R231+LE(237,238)+A241+E257+T261+N265+RIV(268,270,271) [C-G]>C: IR(230,231)+L234+LE(237,238)+A241+T261+N265+RIV(268,270,271) [A-E]>E: WM(602,603)+WGFLHP(607-612) [B-F]>F: M603+WGFLHP(607-612) [D-H]>H: W602+WGFLHP(607-612) [C-G]>G: WGFLHP(607-612) 28 1SLD B-P [B-P]>B: S27+YSA(43,45,46)+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQFC(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 29 2FD6 A-U:1 [A-U]>U: TNGD(8-11)+RTVL(25,27,29,31)+LL(38,40)+RTL(53-55)+K62+LTE(66-68)+T127+DD(140,141)+L144+LP(150,151)+HL(166,168)+D254 [A-U]>A: VSNKYFS(20-26)+IWN(28,30,32)+Q40+H87+K98 30 2I9B A-E:3, B-F:4, A-H:5, B-G:6, C-G:7, D-H:8, C-H:9, D-G:10 [A-E]>E: RT(25,27)+LE(31,33)+ELLE(36,38,40,42)+K50+RLY(53,55,57)+K62+LTE(66-68)+S101+VT(126,127)+PKDD(138-141)+L144+L150+HL(166,168)+DA(254,255) [B-F]>F: RT(25,27)+LE(31,33)+ELLE(36,38,40,42)+K50+RLY(53,55,57)+K62+LTE(66-68)+S101+VT(126,127)+PKDD(138-141)+L144+L150+HL(166,168)+DA(254,255) [A-H]>H: QY(193,195)+E208+L212+KSGC(268-271)+HDL(273,275,276) [B-G]>G: QY(193,195)+E208+L212+KSGC(268-271)+HDL(273,275,276) [C-G]>G: TN(8,9)+RTV(25,27,29)+ELLE(36,38,40,42)+RTL(53-55)+Y57+K62+LTE(66-68)+S101+VT(125,127)+KDD(139-141)+L144+HL(166,168)+E230+DA(254,255) [D-H]>H: TN(8,9)+RTV(25,27,29)+ELLE(36,38,40,42)+RTL(53-55)+Y57+K62+LTE(66-68)+S101+VT(125,127)+KDD(139-141)+L144+HL(166,168)+E230+DA(254,255) [C-H]>H: E185+Q189+D214 [D-G]>G: E185+Q189+D214 [A-E]>A: C11+CVSNKYFSNIHW(19-30)+N32+GQ(39,40)+K46+Y101 [B-F]>B: C11+CVSNKYFSNIHW(19-30)+N32+GQ(39,40)+K46+Y101 [A-H]>A: F57+Y84+HRSD(87-90)+QL(93,94) [B-G]>B: F57+Y84+HRSD(87-90)+QL(93,94) [C-G]>C: CVSNKYFSNIHW(19-30)+NC(32,33)+GQ(39,40)+K98+Y101 [D-H]>D: CVSNKYFSNIHW(19-30)+NC(32,33)+GQ(39,40)+K98+Y101 [C-H]>C: NG(15,16)+F37+F57 [D-G]>D: NG(15,16)+F37+F57 31 3BT1 A-U:1 [A-U]>U: TND(8,9,11)+RTV(25,27,29)+E33+ELLE(36,38,40,42)+RTL(53-55)+K62+LTE(66-68)+VT(126,127)+KD(139,140)+L144+LP(150,151)+HL(166,168)+D254 [A-U]>A: N10+VSNKYFS(20-26)+IW(28,30)+C33+GQ(39,40)+K46+K61+H87 32 3BT2 A-U:1 [A-U]>U: TNGD(8-11)+RTVL(25,27,29,31)+LLE(38,40,42)+RTL(53-55)+LTE(66-68)+S101+TW(127,129)+KDD(139-141)+L144+H166+DA(254,255) [A-U]>A: CVSNKYFS(19-26)+IWN(28,30,32)+GQ(39,40)+AH(86,87)+K98 33 1CN4 A-C:1, B-C:2 [A-C]>A: LE(33,34)+L59+E62+TAD(87-89)+SSFV(91-94)+MSH(150,152,153) [B-C]>B: ED(60,61)+TA(87,88)+TSSFVP(90-95)+H114+E117+M150+H153+PSF(203-205) [A-C]>C: L5+DRV(8,10,11)+R14+Q78+DK(96,97)+S100+RS(103,104)+L108 [B-C]>C: L17+TKVNFY(44-49)+I133+K140+R143+N147+RG(150,151)+KL(154,155) 34 1EER A-B:1, A-C:2 [A-B]>B: LE(33,34)+EDE(60-62)+TA(87,88)+TSSFVP(90-95)+HNE(114,116,117)+H153+EPS(202-204) [A-C]>C: LE(33,34)+L59+E62+TADTSSFV(87-94)+MSH(150,152,153)+S204 [A-B]>A: S9+L16+K20+TKVNFY(44-49)+K52+RI(131,133)+K140+R143+N147+RG(150,151)+KL(154,155) [A-C]>A: L5+DRV(8,10,11)+RY(14,15)+Q78+DK(96,97)+S100+RS(103,104)+TL(107,108) 35 1EBA A-C:2, B-D:3, A-D:4, B-C:5 [A-C]>A: L33+SF(92,93)+PMTSH(149-153)+F205 [B-D]>B: F93+PMTSH(149-153) [A-D]>A: SFV(92-94) [B-C]>B: SSF(91-93)+V194+PS(203,204) [A-C]>C: FGPLTW(8-13) [B-D]>D: FGPLTW(8-13) [A-D]>D: X4 [B-C]>C: X4+T12+CP(15,17) 3,5-dibromotyrosine is denoted by X. 36 1EBP A-C:2, B-D:3, A-D:4, B-C:5 [A-C]>A: F93+PMTSH(149-153)+F205 [B-D]>B: L33+F93+PMTSH(149-153) [A-D]>A: SSFV(91-94) [B-C]>B: SSFV(91-94) [A-C]>C: FGPLTW(8-13) [B-D]>D: FGPLTW(8-13) [A-D]>D: Y4+CP(15,17) [B-C]>C: Y4+CP(15,17) 37 3EZA A-B:1 [A-B]>A: E68+AI(71,72)+EQHML(74-79)+DEL(82,84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) [A-B]>B: LHTR(14-17)+A20+VK(23,24)+K27+KSLF(45-48)+QT(51,52) 38 3EZB A-B:1 [A-B]>A: E68+AI(71,72)+EGHML(74-79)+EL(84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) [A-B]>B: LHTR(314-317)+AA(319,320)+VK(323,324)+K327+KSLF(345-348)+QT(351,352) 39 3EZE A-B:1 [A-B]>A: EE(67,68)+A71+EQHML(74-79)+DEL(82,84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) [A-B]>B: LHTR(314-317)+A320+VK(323,324)+K327+KSLF(345-348)+QT(351,352) 40 1EV2 A-E:1, B-F:2, C-G:3, D-H:4, A-H:5, B-G:6, B-H:7, C-E:8, C-F:9, D-E:10, C-H:11 [A-E]>E: EK(163,164)+LHAVP(166-170)+DVRP(247,249,251,253)+VS(280,282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+NS(346,347)+I350 [B-F]>F: EK(163,164)+LHAVP(166-170)+DVRP(247,249,251,253)+VS(280,282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+NS(346,347) [C-G]>G: EK(163,164)+LHAVP(166-170)+DVRP(247,249,251,253)+VS(280,282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+NS(346,347)+I350 [D-H]>H: EK(163,164)+LHAVP(166-170)+DVRP(247,249,251,253)+VS(280,282)+AQPH(284-287)+AGV(315-317)+TD(320,321)+E325+NS(346,347)+I350 [A-H]>H: R255+I348 [B-G]>G: R255+I348 [B-H]>H: D273+Y328+RN(330,331) [C-E]>E: EK(197,199) [C-F]>F: I348 [D-E]>E: I348 [C-H]>H: L360+P363 [A-E]>A: FK(17,18)+K21+YKG(24,26,28)+F31+R44+LQAEER(55-60)+VS(63,64)+Y73+V88+EL(96,98)+NNYN(101-104)+LPM(140-142) [B-F]>B: FK(17,18)+K21+YKGGF(24,26,28,29,31)+R44+LQAEER(55-60)+VS(63,64)+Y73+V88+EL(96,98)+NNYN(101-104)+LPM(140-142) [C-G]>C: FK(17,18)+YKGGF(24,26,28,29,31)+R44+LQAEER(55-60)+VS(63,64)+V88+EL(96,98)+NYN(102-104)+LPM(140-142) [D-H]>D: FK(17,18)+YKGGF(24,26,28,29,31)+R44+LQAEER(55-60)+VS(63,64)+EL(96,98)+NNYN(101-104)+LPM(140-142) [A-H]>A: S100 [B-G]>B: S100 [B-H]>B: FRE(95,97,99)+R107+Y115+P132 [C-E]>C: D90+K110 [C-F]>C: S100 [D-E]>D: S100 [C-H]>C: PG(132,133) 41 1II4 A-E:1, B-F:2, C-G:3, D-H:4, A-G:5, A-H:6, B-G:7, C-F:8, D-E:9, D-F:10, D-G:11 [A-E]>E: EK(163,164)+LHAVP(166-170)+D247+VERS(249-252)+VYS(280-282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [B-F]>F: EK(163,164)+LHAVP(166-170)+D247+VERSP(249-253)+VYS(280-282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347) [C-G]>G: EK(163,164)+LHAVP(166-170)+D247+VERSP(249-253)+I257+KVYS(279-282)+AQPH(284-287)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [D-H]>H: EK(163,164)+LHAVP(166-170)+D247+VERSP(249-253)+I257+VYS(280-282)+AQPH(284-287)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [A-G]>G: D273+R330+Y328 [A-H]>H: R255+I348 [B-G]>G: R255+I348 [C-F]>F: I348 [D-E]>E: I348 [D-F]>F: EK(197,199) [D-G]>G: L360 [A-E]>A: FP(21,22)+GHFK(24-27)+K30+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+VS(72,73)+Y82+V97+E105+L107+NNYN(110-113)+LPM(149-151) [B-F]>B: FP(21,22)+GHFK(24-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+VS(72,73)+Y82+V97+E105+L107+NNYN(110-113)+LPM(149-151) [C-G]>C: FP(21,22)+GHFK(24-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+V72+E105+L107+NNYN(110-113)+LPM(149-151) [D-H]>D: FP(21,22)+GHFK(24-27)+Y30+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+V72+E105+L107+NNYN(110-113)+LPM(149-151) [A-G]>A: R106+R116+P141 [A-H]>A: SN(109,111) [B-G]>B: SN(109,111) [C-F]>C: S109 [D-E]>D: S109 [D-F]>D: D99+K119 [D-G]>D: P141 42 1IIL A-E:1, B-F:2, A-G:3, A-H:4, B-G:5, C-F:6, D-E:7, C-G:8, D-H:9, D-F:10, D-G:11 [A-E]>E: EK(163,164)+LHAVP(166-170)+N173+VERSR(249-253)+VYS(280-282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [B-F]>F: EK(163,164)+LHAVP(166-170)+N173+D247+VERSR(249-253)+VYS(280-282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [A-G]>G: D273+RN(330,331)+Y328 [A-H]>H: HR(254,255)+I348 [B-G]>G: HR(254,255)+I348 [C-F]>F: HR(254,255)+I348 [D-E]>E: HR(254,255)+I348 [C-G]>G: EK(163,164)+LHAVP(166-170)+N173+D247+RSR(251-253)+VS(280,282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [D-H]>H: EK(163,164)+LHAVP(166-170)+N173+D247+RSR(251-253)+KVS(279,280,282)+AQPH(284-287)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [D-F]>F: EK(197,199) [D-G]>G: LAP(360,362,363) [A-E]>A: PP(22,23)+HFK(25-27)+YKGF(33,35,37,40)+R53+LQAEER(64-69)+VS(72,73)+Y82+V97+E105+LESNNYN(107-113)+LPM(149-151) [B-F]>B: PP(22,23)+HFK(25-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+VS(72,73)+Y82+V97+E105+LESNNYN(107-113)+LPM(149-151) [A-G]>A: FR(104,106)+R116+TSY(121,122,124)+P141 [A-H]>A: SN(109,111) [B-G]>B: SNN(109-111) [C-F]>C: SNN(109-111) [D-E]>D: SNN(109-111) [C-G]>C: HFK(25-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+V72+E105+LESNNYN(107-113)+LPM(149-151) [D-H]>D: HFK(25-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+V72+F102+E105+LESNNYN(107-113)+LPM(149-151) [D-F]>D: D99+K119 [D-G]>D: PG(141,142) 43 2H1P H-P:2, L-P:3 [H-P]>H: F333+KTY(357-359)+R399+A403+L405 [L-P]>L: Q27+VHN(30,31,33)+STHV(96-99)+W101 [H-P]>P: WMLV(608-611) [L-P]>P: LQYT(602-605)+ML(609,610) 44 1G9M G-H:2, G-L:3 [G-H]>H: I52+LVH(55,57,59)+E103+EGEYR(106-110) [G-L]>L: WP(94,95) [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) 45 1G9N G-H:2, G-L:3 [G-H]>H: LVH(55,57,59)+E103+EGEYR(106-110) [G-L]>L: WP(94,95) [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) 46 1RZJ G-H:2, G-L:3 [G-H]>H: LVH(54,56,58)+E99+EGEYDN(100B-110G) [G-L]>L: WP(94,95) [G-H]>G: VL(120,122)+T202+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) 47 1RZK G-H:2, G-L:3 [G-H]>H: LVH(54,56,58)+E99+EGEYD(100B-110F) [G-L]>L: WP(94,95) [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+P437 [G-L]>G: C119+TQ(202,203) 48 2NXY A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+P437 49 2NXZ A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 50 2NY0 A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437