26 Virion infectivity factor Protein>Others P12504 Vif SOR protein Human immunodeficiency virus type 1 (isolate NY5 group M subtype B) (HIV-1):11698 3DCG Vif forms a complex with host APOBEC3F and APOBEC3G and directs them for proteasomal degradation. APOBEC3F and APOBEC3G are cytidine deaminases that can disrupts viral nucleic acids. Thus, Vif is very important for viral replication. 27 Anti-ViCPS monoclonal antibody ATVi Protein>Monoclonal antibody Mab ATVi Mus musculus (Mouse):10090 The MAb ATVi was produced against Vi polysaccharide antigen of Salmonella typhi. It was found to be highly specific to Vi possessing bacteria (PMID: 8216560). 28 Polyclonal antibody PTS Protein>Polyclonal antibody Homo sapiens (Human):9606 Polyclonal antibody PTS were from pooled sera of 10 typhoid patients. These patients was confirmed typhoid fever by high antibody titers (>1:640) for one or both O and H antigens, as determined by Widal test. 29 Anti-IL-4 monoclonal antibody 11B.11 Protein>Monoclonal antibody GI:50812705, GI:50812707 Mab 11B.11 Mab 11B11 Rattus norvegicus (Rat):10116 Mab 11B11 is a rat anti-mouse interleukin-4 monoclonal antibody of IgG1 isotype. The immunogen used to generate the 11B11 hybridoma was partially purified mouse IL-4 from PMA-stimulated EL-4 supernatant. Mab 11B11 binds with high affinity to and neutralizes both natural and recombinant mouse IL-4. It was found that administration of 11B11, like soluble IL-4R, similarly inhibited IgE production in response to anti-IgD. 30 Plasminogen activator inhibitor 1 Protein>Others P05121 PAI, PAI-1 Endothelial plasminogen activator inhibitor Serpin E1 Homo sapiens (Human):9606 1A7C, 1B3K, 1C5G, 1DB2, 1DVM, 1DVN, 1LJ5, 1OC0, 3CVM, 3EOX, 3PB1, 3Q02, 3Q03, 3R4L, 3UT3, 4AQH, 9PAI Plasminogen activator inhibitor 1 acts as trap for tissue plasminogen activator (TPA), urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. 31 Kallikrein-2 Protein>Enzyme P20151 Tissue kallikrein-2 Glandular kallikrein-1, hGK-1 EC=3.4.21.35 Homo sapiens (Human):9606 Kallikrein-2 cleaves Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. It has 3 isoforms produced by alternative splicing. 32 Listeria monocytogenes Cell GI:47097775 (serotype 1/2a str. F6854) GI:47094674 (serotype 4b str. H7858) GI:83316099 (serotype 4b str. F2365) GI:16802048 (EGD-e) L. monocytogenes Listeria monocytogenes:1639 Listeria monocytogenes is a facultative anaerobe, which lives in the cell. It is one of the most virulent foodborne pathogens, causing listeriosis. 33 Prostate-specific antigen Protein>Enzyme P07288 PSA Gamma-seminoprotein Seminin Kallikrein-3 P-30 antigen Semenogelase EC=3.4.21.77 Homo sapiens (Human):9606 2ZCH, 2ZCK, 2ZCL, 3QUM PSA is a serine protease (-Tyr-|-Xaa-) produced almost exclusively by the prostate gland. It hydrolyze semenogelin-1, leading to the liquefaction of the seminal coagulum, which allows sperm to swim freely. PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer and in other prostate disorders. 34 Macrophage receptor MARCO Protein>Receptor Q60754 Macrophage receptor with collagenous structure Mus musculus (Mouse):10090 2OY3, 2OYA MARCO is a pattern recognition receptor containing a collagen-like domain and a scavenger receptor cysteine-rich (SRCR) domain. As a member of the class A scavenger receptor family, MARCO may bind both Gram-negative and Gram-positive bacteria via its intracellular, C-terminal SRCR domain. 35 Heat shock cognate 71 kDa protein Protein>Others P19120 Heat shock 70 kDa protein 8 HSPA8, HSC70, HSP73 Bos taurus (Bovine):9913 1ATR, 1ATS, 1BA0, 1BA1, 1BUP, 1HPM, 1HX1, 1KAX, 1KAY, 1KAZ, 1NGA, 1NGB, 1NGC, 1NGD, 1NGE, 1NGF, 1NGG, 1NGH, 1NGI, 1NGJ, 1Q2G, 1QQM, 1QQN, 1QQO, 1YUW, 2BUP, 2QW9, 2QWL, 2QWM, 2QWN, 2QWO, 2QWP, 2QWQ, 2QWR, 3C7N, 3HSC Heat shock cognate 71 kDa protein is constitutively expressed. It binds to nascent polypeptides to facilitate correct protein folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. 36 Cetuximab Protein>Monoclonal antibody GI:66361252, GI:66361253 IMC-C225 Erbitux Homo sapiens (Human):9606, Mus musculus (Mouse):10090 1YY8, 1YY9 Cetuximab is a chimeric (mouse/human) IgG1κ antibody against epidermal growth factor receptor (EGFR). As an EGFR inhibitor, it was given by intravenous infusion for treatment of metastatic colorectal cancer and head and neck cancer. 37 Trastuzumab Protein>Monoclonal antibody GI:28948772 , GI:28948773 Herceptin, rhuMab4D5 Homo sapiens (Human):9606 1N8Z, 3D6G Trastuzumab is a humanized IgG1κ antibody from its original version mumAb4D5, a mouse monoclonal antibody. The mumAb4D5 was generated against a HER2 over-expressing NIH 3T3 cell line. The recombinant humanized version of mumAb4D5 is also known as rhuMab4D5 and Herceptin (trade name). 38 Anti-omp40 monoclonal antibody Pg-ompA1 Protein>Monoclonal antibody Unknown 39 Anti-vWF monoclonal antibody 82D6A3 Protein>Monoclonal antibody GI:83753978, GI:83753979 Mab 82D6A3 Mus musculus (Mouse):10090 2ADF The mouse monoclonal antibody 82D6A3 is an IgG2aκ raised against human von Willebrand factor (vWF). It binds with high affinity to the VWF A3-domain and inhibits VWF binding to collagen types I, III and IV, but has no effect on vWF binding to collagen VI. Interestingly, its antithrombotic effect is not associated with significantly increased bleeding times, even at high doses. 40 Anti-coagulation factor VIII monoclonal antibody BO2C11 Protein>Monoclonal antibody GI:15825659 , GI:15825660 Mab BO2C11, MoAb BO2C11 Homo sapiens (Human):9606 1IQD The anti-coagulation factor VIII monoclonal antibody BO2C11 is a human IgG4k antibody produced by a cell line derived from the memory B-cell repertoire of a hemophilia A patient with inhibitor. BO2C11 recognizes the C2 domain of factor VIII and inhibits its binding to both von Willebrand factor (vWF) and phospholipids. It completely inhibits the procoagulant activity of native and activated factor VIII. 41 Anti-spike glycoprotein monoclonal antibody 80R Protein>Monoclonal antibody GI:116667257, GI:116667259 Mab 80R Homo sapiens (Human):9606 2GHW The monoclonal antibody 80R is a human IgG1κ selected from an nonimmune phage antibody library with recombinant S1 domain of spike protein of the SARS-CoV as antigen. It efficiently neutralizs SARS-CoV and inhibited syncytia formation between cells expressing the S protein and those expressing the SARS-CoV receptor angiotensin-converting enzyme 2 (ACE2). 42 Anti-gp120 monoclonal antibody b12 Protein>Monoclonal antibody GI:126031291, GI:126031292 Mab b12 Homo sapiens (Human):9606 1HZH, 2NY7 The b12 was a human monoclonal IgG1 selected with recombinant gp120 from a phage Fab library that was constructed using bone marrow cDNA of an HIV-1-infected individual. The ability of b12 to neutralize laboratory-adapted HIV-1, primary HIV-1 isolates, and interfere both with the binding of gpl20 to CD4 and the interaction of gpl20 to CCR5 has been reported. 43 Cytochrome b-245 Protein>Others Cytochrome b-245 light chain: P13498, Cytochrome b-245 heavy chain: P04839 Cytochrome b-245 light chain alternative name(s): p22 phagocyte B-cytochrome Neutrophil cytochrome b 22 kDa polypeptide p22-phox, p22phox Cytochrome b(558) alpha chain Cytochrome b558 subunit alpha Superoxide-generating NADPH oxidase light chain subunit Cytochrome b-245 heavy chain alternative name(s): p22 phagocyte B-cytochrome Neutrophil cytochrome b 91 kDa polypeptide Heme-binding membrane glycoprotein gp91phox CGD91-phox gp91-phox gp91-1 Cytochrome b(558) subunit beta, Cytochrome b558 subunit beta Superoxide-generating NADPH oxidase heavy chain subunit NADPH oxidase 2 Homo sapiens (Human):9606 Cytochrome b-245 light chain: 1WLP Cytochrome b-245 heavy chain: 3A1F 44 Neutrophil cytosol factor 1 Protein>Others P14598 NCF-1 Neutrophil NADPH oxidase factor 1 47 kDa neutrophil oxidase factor p47-phox NCF-47K 47 kDa autosomal chronic granulomatous disease protein Nox-organizing protein 2 Nox organizer 2 SH3 and PX domain-containing protein 1A Homo sapiens (Human):9606 1GD5, 1K4U, 1KQ6, 1NG2, 1O7K, 1OV3, 1UEC, 1W70, 1WLP 45 Bacillus subtilis spores Cell Bacillus subtilis:1423 46 Tryptase Protein>Enzyme Q02844 Mast cell protease 7, mMCP-7 Tryptase alpha/beta-1 EC=3.4.21.59 Mus musculus (Mouse):10090 47 Cryptococcus neoformans melanin Protein>Others Cryptococcus neoformans (Filobasidiella neoformans):5207 48 Growth factor receptor-bound protein 2 Protein>Others P62993 Adapter protein GRB2 SH2/SH3 adapter GRB2 Protein Ash Homo sapiens (Human):9606 1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H46, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O 49 Urokinase-type plasminogen activator Protein>Others P00749 U-plasminogen activator, uPA Homo sapiens (Human):9606 1C5W, 1C5X, 1C5Y, 1C5Z, 1EJN, 1F5K, 1F5L, 1F92, 1FV9, 1GI7, 1GI8, 1GI9, 1GJ7, 1GJ8, 1GJ9, 1GJA, 1GJB, 1GJC, 1GJD, 1KDU, 1LMW, 1O3P, 1O5A, 1O5B, 1O5C, 1OWD, 1OWE, 1OWH, 1OWI, 1OWJ, 1OWK, 1SC8, 1SQA, 1SQO, 1SQT, 1U6Q, 1URK, 1VJ9, 1VJA, 1W0Z, 1W10, 1W11, 1W12, 1W13, 1W14, 2FD6, 2I9A, 2I9B, 2NWN, 2O8T, 2O8U, 2O8W, 2R2W, 2VIN, 2VIO, 2VIP, 2VIQ, 2VIV, 2VIW, 2VNT, 3BT1, 3BT2, 3IG6, 3KGP, 3KHV, 3KID, 3M61, 3MHW, 3MWI, 3OX7, 3OY5, 3OY6, 3PB1, 3QN7, 3U73, 4DVA, 4DW2, 4FU7, 4FU8, 4FU9, 4FUB, 4FUC, 4FUD, 4FUE, 4FUF, 4FUG, 4FUH, 4FUI, 4FUJ, 4GLY 50 Melanocyte-stimulating hormone receptor, MSH-R Protein>Receptor Q01726 Melanocortin receptor 1, MC1-R Homo sapiens (Human):9606