1 1G1S A-D:2, B-C:3 [A-D]>A: A9+YSS(45-47)+R85+H108+LKK(110-112)+H114 [B-C]>B: A9+YSS(45-47)+R85+H108+LKK(110-112)+H114 [A-D]>D: EYL(606-608)+Y610+FLP(612-614)+T616 [B-C]>C: EYL(606-608)+Y610+FLP(612-614)+T616 2 2OSL A-Q:3, B-Q:6, H-P:7, L-P:8 [A-Q]>A: NH(33,35)+W47+AY(50,52)+NDS(55,57,59)+S99+Y102+W106 [B-Q]>B: W90+NP(93,95) [H-P]>H: NH(33,35)+W47+AIY(50-52)+DTS(57-59)+S99+Y102+W106 [L-P]>L: W90+NP(93,95) [A-Q]>Q: EPANPSEKP(168-176) [B-Q]>Q: NEAN(166,168,170,171) [H-P]>P: EPANPSEK(168-175) [L-P]>P: EPAN(168-171) 3 3IU3 A-K:4, H-I:5, B-K:7, C-J:8, D-J:10, I-L:12 [A-K]>A: S26+R29+YW(30,31)+Y50+N53+DYG(97-99)+Y100 [H-I]>H: S26+R29+YW(30,31)+YNDS(50,53,55,57)+E63+DYG(97-99)+Y100 [B-K]>B: SY(30,31)+D49+K52+R90+Y93 [C-J]>C: YS(25,26)+R29+YWH(30,31,33)+AY(48,50)+N53+S57+DYG(97-99)+Y100 [D-J]>D: SY(30,31)+D49+K52+RSY(90,91,93) [I-L]>L: RSY(29-31)+D49+K52+RSSY(90-93) [A-K]>K: EL(1,2)+DDD(4-6)+EGMNE(22,23,25,27,29)+LYLT(42,43,45,47)+H120 [H-I]>I: EL(1,2)+DDD(4-6)+EGMNE(22,23,25,27,29)+RK(36,38)+LY(42,43)+T47+H120 [B-K]>K: LY(42,43)+LTG(45,47,48)+DN(56,57) [C-J]>J: EL(1,2)+DDD(4-6)+EGMNE(22,23,25,27,29)+LYLT(42,43,45,47)+YH(119,120) [D-J]>J: LY(42,43)+LTG(45,47,48)+DN(56,57) [I-L]>I: SG(39,40)+LYLTG(42,43,45,47,48)+DN(56,57) 4 1TET H-P:2, L-P:3 [H-P]>H: TTYG(30-33)+NNY(52,52A,53)+RS(95,96)+W100A [L-P]>L: HSGNY(31,31B,31C,31D,32)+K50+GS(91,92)+F96 [H-P]>P: VPGSQHI(3-9) [L-P]>P: VPG(3-5)+DSQK(10-13) 5 1OC0 A-B:1 [A-B]>A: R101+MP(110,111)+F114+T120+KQVD(122-125)+R131+I135+DW(138,139) [A-B]>B: TGF(10,12,13)+DEL(22-24)+YYQS(27-30) 6 1HX1 A-B:1 [A-B]>A: TD(45,46)+N57+AMN(60-62)+R258+RR(261,262)+T265+R269+S281+EIDS(283-286)+GDY(290,292,294) [A-B]>B: R205+KA(208,209)+IE(211,212)+MK(215,216)+E219+DTLIL(222-226)+R234+RK(237,238)+VK(241,142)+Q245+D252 7 1YY9 A-C:1, A-D:2 [A-C]>C: Q27+Y50+NNNW(91-94) [A-D]>D: N31+W52+GGN(54-56)+D58+TYYDY(100-104) [A-C]>A: K443+K465+ISN(467-469)+GN(471,473) [A-D]>A: P439+R353+LQ(382,384)+QHQF(408,409,411,412)+VS(417,418)+ISGKKIS(438,440,441,443,465,467,468) 8 1N8Z A-C:2, B-C:3 [A-C]>A: NAT(30-32)+S50+F53+HYT(91,92,94) [B-C]>B: Y33+R50+YR(57,59)+GY(103,105) [A-C]>C: D560+KPP(569,571,572)+DEA(596,598,600)+QPC(602-604) [B-C]>C: PEDQ(557,558,560,561)+DPF(570,571,573)+IK(591,593) 9 2ADF A-H:1, A-L:2 [A-H]>H: NY(31,32)+WNN(50,52,54)+DNPYY(99-103) [A-L]>L: Y32+H49+T53+P56+D92+R95 [A-H]>A: ITTID(975-979)+PWN(981-983)+D1009+GF(1012,1013)+RY(1016,1017)+MH(1022,1023) [A-L]>A: I975+D1009+R1016+M1022 10 1IQD A-C:2, B-C:3 [A-C]>A: SSY(30,32,33)+Y50+T54+T57+YGT(92-94)+I97 [B-C]>B: QV(1,2)+Y27+TELP(30-33)+H35+SFD(50-52)+E54+EI(57,59)+V95+DPD(97-99) [A-C]>C: FTNM(2196-2199)+QV(2222,2223)+HQ(2315,2316) [B-C]>C: F2196+NMF(2198-2200)+R2215+R2220+SLLT(2250-2253)+M2255 11 2GHW A-B:1, C-D:2 [A-B]>B: SYA(31-33)+SY(52,53)+NY(57,59)+DRSY(99-102)+R150+RSN(162-164)+DST(182,184,185)+SGS(195-197)+S199+DTT(202,204,206)+RS(223,224) [C-D]>D: SYA(31-33)+SY(52,53)+NY(57,59)+DRSY(99-102)+R150+RSN(162-164)+DS(182,184)+SGS(195-197)+S199+DTT(202,204,206)+RS(223,224) [A-B]>A: R426+S432+Y436+K439+Y442+PPAL(469-472)+CYW(474-476)+LND(478-480)+G482+YTTTG(484-488)+YQ(491,492) [C-D]>C: R426+S432+Y436+KYY(439,440,442)+PPAL(469-472)+CYW(474-476)+LND(478-480)+G482+YTTTG(484-488)+YQ(491,492) 12 2NY7 G-H:1 [G-H]>H: R28+SNFV(30-33)+NYN(52-54)+N56+GPY(96-98)+WNY(100,100G,100H) [G-H]>G: NA(280,281)+SGGDP(365-369)+IVT(371-373)+YN(384,386)+PR(417,419)+VGK(430-432)+TR(455,456)+GGDM(472-475) 13 1WLP A-B:1 [A-B]>A: SKQPP(5-9)+NPPPRPP(11-17)+EA(19,20) [A-B]>B: I164+Y167+S171+E174+E187+SGW(191-193)+F195+WP(204,206)+SF(208,209)+E241+DE(243,244)+W263+PMY(276,278,279) 14 1K4U P-S:1 [P-S]>S: FY(466,468)+PED(473-475)+KVN(489-491)+WE(494,496)+VGI(503-505)+PVF(507,509,510) [P-S]>P: QPVPRP(362,363,365,366,368,369)+LI(373,374)+RCS(377-379)+ST(381,382)+KL(385,386) 15 1GC1 G-H:2, G-L:3 [G-H]>H: LVH(55,57,59)+E103+EGEYDN(106-111) [G-L]>L: WP(94,95) [G-H]>G: K121+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203)+M434 16 1E6J H-P:2, L-P:3 [H-P]>H: TSYT(30-33)+YN(50,52)+YN(57,59)+V101+Y105 [L-P]>L: WNY(90-92)+F94 [H-P]>P: LGPAAT(205-210)+EE(212,213)+TA(216,217) [L-P]>P: AL(204,205) 17 2GRX A-C:1, B-D:2 [A-C]>C: RQ(158,160)+Y163+R166+QAL(168-170)+NMER(200,201,203,204)+N208+R211+VVNILFK(225-231)+N233 [B-D]>D: R166+ALR(169-171)+NM(200,201)+R204 [A-C]>A: TITVTAAPA(8-16)+AT(26,27)+EP(159,160)+DP(542,544)+ASA(588,590,591)+N594+F634+D676+AG(683,684)+RF(724,725) [B-D]>B: DP(542,544)+ASA(588,590,591)+F634+D676+A683 18 2GSK A-B:1 [A-B]>B: RQPY(158,160,161,163)+AR(165,166)+QALR(168-171)+AN(199,200)+ER(203,204)+K207+RRW(211-213)+VVNILFK(225-231)+N233 [A-B]>A: PDTLVVTAN(5-13)+EP(16,18)+V22+Q32+I305+GHG(307-309)+LQ(345,347)+GR(382,384)+EGL(423-425)+GN(428,430)+D471+GPLT(473-476) 19 1FLT V-X:2, W-Y:3, V-Y:4, W-X:5 [V-X]>V: K48+M81+H86+QI(89,91) [W-Y]>W: K48+MI(81,83)+QI(89,91) [V-Y]>V: FM(17,18)+YQ(21,22)+Y25+DGL(63,65,66)+CRP(104-106) [W-X]>W: FM(17,18)+YQ(21,22)+Y25+DGL(63,65,66)+ECRP(103-106) [V-X]>X: I142+H147+LHQ(221,223,225) [W-Y]>Y: IPIH(142,143,145,147)+LH(221,223) [V-X]>Y: EIP(141-143)+KFP(171-173)+Y199+IGL(202-204)+R224 [W-X]>X: EIP(141-143)+KF(171,172)+YK(199,200)+GL(203,204)+L221+R224 20 1SHY A-B:1 [A-B]>B: TYYD(124-127)+H148+E167+DRF(190-192)+R218+KETK(220-223)+LT(229,230)+S286 [A-B]>A: Y513+K516+RQ(533,534)+P537+D578+Y619+RK(647,649)+E656+CE(669,670)+Y673+VPGRGC(692-697)+R702 21 1M10 A-B:1 [A-B]>B: ESV(5,7,9)+SHEN(11,12,14,16)+H37+QE(127,128)+K152+DT(175,176)+PF(198,199)+ENY(225,226,228)+DVKAVTS(235-241) [A-B]>A: K549+DGSHAY(560-565)+R571+I580+E596+KY(599,600)+FQ(603,604)+SK(607,608)+E613+R632 22 1SQ0 A-B:1 [A-B]>B: E5+KV(8,9)+A10+ND(16,18)+HS(37,39)+N61+K152+DT(175,176)+PF(198,199)+ENY(225,226,228)+DVKAMT(235-240) [A-B]>A: L512+KW(549,550)+GSHAY(561-565)+R571+I580+E596+KY(599,600)+FQ(603,604)+E613+R632 23 1U0N A-D:3 [A-D]>D: SVA(7,9,10)+EN(14,16)+TV(103,104)+QE(127,128)+K152+DT(175,176)+PF(198,199)+ENY(225,226,228)+DVKAVTS(235-241) [A-D]>A: K549+DGSHAY(560-565)+R571+I580+E596+KY(599,600)+FQ(603,604)+SK(607,608)+E613+R632 24 1D0G A-R:4, B-S:5, D-T:6, A-S:7, B-T:8, D-R:9 [A-R]>R: FCR(59,60,62)+RD(65,67)+EM(98,99)+K102 [B-S]>S: FCR(59,60,62)+D67+EMC(98-100)+K102 [D-T]>T: E36+LF(58,59)+R62+DS(67,68)+EM(98,99)+K102 [A-S]>S: TH(52,53)+NDL(55-57)+L61+EDSPEM(94-99)+RKR(101,102,104)+P108+M111+D122+C125 [B-T]>T: TH(52,53)+NDL(56-57)+L61+DSPEM(95-99)+RKR(101,102,104)+M111+D122+C125 [D-R]>R: TH(52,53)+ND(55,56)+L61+F91+EDSPEM(94-99)+RKR(101,102,104)+P108+M111+D122+C125 [A-R]>A: GTRG(128-131)+E155+RS(158,159)+YRQE(189,191,193,195)+EYL(236,237,239) [B-S]>B: E155+SRSG(157-160)+Y189+RFQ(191-193)+EY(236,237)+H270 [D-T]>D: G128+SRSG(157-160)+YRQE(189,191,193,195)+E236+L239 [A-S]>A: R149+NTK(199-201)+DQ(203,205)+Y209+SYPD(215-218)+K224+TN(261,262) [B-T]>B: NTK(199-201)+DQ(203,205)+Y209+SYPD(215-218)+K224+TN(261,262) [D-R]>D: R149+ENTK(198-201)+DQVY(203,205,207,209)+SYPD(215-218)+K224+TN(261,262) 25 1D4V A-B:1 [A-B]>A: Q101+F112+RCT(115-117)+D120+EMCRK(151-155) [A-B]>B: RR(130,132)+E155+RSGH(158-161)+YRQ(189,191,193)+EYL(236,237,239) 26 1DU3 A-D:1, C-F:2, H-K:3, I-L:4, A-F:5, C-E:6, H-J:7, I-K:8, B-D:9, G-L:10, B-E:11, G-J:12, C-L:13 [A-D]>A: E36+Y50+LF(58,59)+LRCTRCD(61-67)+E70+C84+R92+EMC(98-100)+K102 [C-F]>C: Y50+F59+LRCTR(61-65)+D67+E70+N81+C84+EMC(98-100)+K102 [H-K]>H: Y50+F59+LRCTRCD(61-67)+E70+N81+C84+R92+EMC(98-100)+K102 [I-L]>I: Y50+F59+LRCTR(61-65)+D67+E70+N81+C84+EM(98,99)+K102 [A-F]>A: THND(52,53,55,56)+F91+EDSPEM(94-99)+RK(101,102)+D122 [C-E]>C: TH(52,53)+NDL(55-57)+L61+F91+EDSPEM(94-99)+RK(101,102)+D122 [H-J]>H: THND(52,53,55,56)+L61+F91+EDSPEM(94-99)+RK(101,102) [I-K]>I: THND(52,53,55,56)+EDSPEM(94-99)+RK(101,102) [B-D]>B: TH(52,53)+D56+L61+EDSPEM(94-99)+RKR(101,102,104)+CP(107,108)+M111 [G-L]>G: TH(52,53)+NDL(55-57)+L61+EDSPEM(94-99)+RKR(101,102,104)+P108+M111+D122+C125 [B-E]>B: Y50+F59+LRCTRCD(61-67)+E70+N81+C84+R92+EMC(98-100) [G-J]>G: Y50+LF(58,59)+RCTRCD(62-67)+E70+N81+C84+R92+EMCRK(98-102) [C-L]>C: YG(46,47)+EL(72,73)+PCT(75-77)+TR(79,80) [A-D]>D: TRGRSN(129-134)+E155+RSG(158-160)+YRQ(189,191,193)+EYL(236,237,239) [C-F]>F: GTRGRSNT(128-135)+E155+RSH(158,159,161)+YRQE(189,191,193,195)+EYL(236,237,239)+H270 [H-K]>K: RGRSNT(130-135)+RSG(158-160)+YRQ(189,191,193)+EYL(236,237,239) [I-L]>L: RGRSNT(130-135)+RSGH(158-161)+YR(189,191)+E236+L239 [A-F]>F: LR(147,149)+KDQVY(201,203,205,207,209)+SYPD(215-218)+K224+TD(261,262) [C-E]>E: LR(147,149)+KDQ(201,203,205)+Y209+SYPD(215-218)+K224+TD(261,262) [H-J]>J: LR(147,149)+KDQVY(201,203,205,207,209)+SYPD(215-218)+K224+TD(261,262) [I-K]>K: LR(147,149)+KDQVY(201,203,205,207,209)+SYPD(215-218)+K224+TD(261,262) [B-D]>D: LR(147,149)+NTK(199-201)+DQ(203,205)+Y209+SYPD(215-218)+K224+TD(261,262) [G-L]>L: LR(147,149)+EN(198,199)+KDQVY(201,203,205,207,209)+SYPD(215-218)+K224+TN(261,262) [B-E]>E: RGRSNT(130-135)+RS(158,159)+Y189+RFQ(191-193)+YL(237,239) [G-J]>J: TRGRSNT(129-135)+RSG(158-160)+YRQ(189,191,193)+EYL(236,237,239) [C-L]>L: HRN(168,170,171)+H177+NR(253,255) 27 1DKD A-E:2, B-F:3, D-H:4, C-G:6 [A-E]>A: R231+LE(237,238)+A241+T261+N265+RIV(268,270,271) [B-F]>B: R231+L234+LE(237,238)+A241+T261+N265+RIV(268,270,271) [D-H]>D: R231+LE(237,238)+A241+E257+T261+N265+RIV(268,270,271) [C-G]>C: IR(230,231)+L234+LE(237,238)+A241+T261+N265+RIV(268,270,271) [A-E]>E: WM(602,603)+WGFLHP(607-612) [B-F]>F: M603+WGFLHP(607-612) [D-H]>H: W602+WGFLHP(607-612) [C-G]>G: WGFLHP(607-612) 28 1SLD B-P [B-P]>B: S27+YSA(43,45,46)+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQFC(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 29 2FD6 A-U:1 [A-U]>U: TNGD(8-11)+RTVL(25,27,29,31)+LL(38,40)+RTL(53-55)+K62+LTE(66-68)+T127+DD(140,141)+L144+LP(150,151)+HL(166,168)+D254 [A-U]>A: VSNKYFS(20-26)+IWN(28,30,32)+Q40+H87+K98 30 2I9B A-E:3, B-F:4, A-H:5, B-G:6, C-G:7, D-H:8, C-H:9, D-G:10 [A-E]>E: RT(25,27)+LE(31,33)+ELLE(36,38,40,42)+K50+RLY(53,55,57)+K62+LTE(66-68)+S101+VT(126,127)+PKDD(138-141)+L144+L150+HL(166,168)+DA(254,255) [B-F]>F: RT(25,27)+LE(31,33)+ELLE(36,38,40,42)+K50+RLY(53,55,57)+K62+LTE(66-68)+S101+VT(126,127)+PKDD(138-141)+L144+L150+HL(166,168)+DA(254,255) [A-H]>H: QY(193,195)+E208+L212+KSGC(268-271)+HDL(273,275,276) [B-G]>G: QY(193,195)+E208+L212+KSGC(268-271)+HDL(273,275,276) [C-G]>G: TN(8,9)+RTV(25,27,29)+ELLE(36,38,40,42)+RTL(53-55)+Y57+K62+LTE(66-68)+S101+VT(125,127)+KDD(139-141)+L144+HL(166,168)+E230+DA(254,255) [D-H]>H: TN(8,9)+RTV(25,27,29)+ELLE(36,38,40,42)+RTL(53-55)+Y57+K62+LTE(66-68)+S101+VT(125,127)+KDD(139-141)+L144+HL(166,168)+E230+DA(254,255) [C-H]>H: E185+Q189+D214 [D-G]>G: E185+Q189+D214 [A-E]>A: C11+CVSNKYFSNIHW(19-30)+N32+GQ(39,40)+K46+Y101 [B-F]>B: C11+CVSNKYFSNIHW(19-30)+N32+GQ(39,40)+K46+Y101 [A-H]>A: F57+Y84+HRSD(87-90)+QL(93,94) [B-G]>B: F57+Y84+HRSD(87-90)+QL(93,94) [C-G]>C: CVSNKYFSNIHW(19-30)+NC(32,33)+GQ(39,40)+K98+Y101 [D-H]>D: CVSNKYFSNIHW(19-30)+NC(32,33)+GQ(39,40)+K98+Y101 [C-H]>C: NG(15,16)+F37+F57 [D-G]>D: NG(15,16)+F37+F57 31 3BT1 A-U:1 [A-U]>U: TND(8,9,11)+RTV(25,27,29)+E33+ELLE(36,38,40,42)+RTL(53-55)+K62+LTE(66-68)+VT(126,127)+KD(139,140)+L144+LP(150,151)+HL(166,168)+D254 [A-U]>A: N10+VSNKYFS(20-26)+IW(28,30)+C33+GQ(39,40)+K46+K61+H87 32 3BT2 A-U:1 [A-U]>U: TNGD(8-11)+RTVL(25,27,29,31)+LLE(38,40,42)+RTL(53-55)+LTE(66-68)+S101+TW(127,129)+KDD(139-141)+L144+H166+DA(254,255) [A-U]>A: CVSNKYFS(19-26)+IWN(28,30,32)+GQ(39,40)+AH(86,87)+K98 33 1CN4 A-C:1, B-C:2 [A-C]>A: LE(33,34)+L59+E62+TAD(87-89)+SSFV(91-94)+MSH(150,152,153) [B-C]>B: ED(60,61)+TA(87,88)+TSSFVP(90-95)+H114+E117+M150+H153+PSF(203-205) [A-C]>C: L5+DRV(8,10,11)+R14+Q78+DK(96,97)+S100+RS(103,104)+L108 [B-C]>C: L17+TKVNFY(44-49)+I133+K140+R143+N147+RG(150,151)+KL(154,155) 34 1EER A-B:1, A-C:2 [A-B]>B: LE(33,34)+EDE(60-62)+TA(87,88)+TSSFVP(90-95)+HNE(114,116,117)+H153+EPS(202-204) [A-C]>C: LE(33,34)+L59+E62+TADTSSFV(87-94)+MSH(150,152,153)+S204 [A-B]>A: S9+L16+K20+TKVNFY(44-49)+K52+RI(131,133)+K140+R143+N147+RG(150,151)+KL(154,155) [A-C]>A: L5+DRV(8,10,11)+RY(14,15)+Q78+DK(96,97)+S100+RS(103,104)+TL(107,108) 35 1EBA A-C:2, B-D:3, A-D:4, B-C:5 [A-C]>A: L33+SF(92,93)+PMTSH(149-153)+F205 [B-D]>B: F93+PMTSH(149-153) [A-D]>A: SFV(92-94) [B-C]>B: SSF(91-93)+V194+PS(203,204) [A-C]>C: FGPLTW(8-13) [B-D]>D: FGPLTW(8-13) [A-D]>D: X4 [B-C]>C: X4+T12+CP(15,17) 3,5-dibromotyrosine is denoted by X. 36 1EBP A-C:2, B-D:3, A-D:4, B-C:5 [A-C]>A: F93+PMTSH(149-153)+F205 [B-D]>B: L33+F93+PMTSH(149-153) [A-D]>A: SSFV(91-94) [B-C]>B: SSFV(91-94) [A-C]>C: FGPLTW(8-13) [B-D]>D: FGPLTW(8-13) [A-D]>D: Y4+CP(15,17) [B-C]>C: Y4+CP(15,17) 37 3EZA A-B:1 [A-B]>A: E68+AI(71,72)+EQHML(74-79)+DEL(82,84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) [A-B]>B: LHTR(14-17)+A20+VK(23,24)+K27+KSLF(45-48)+QT(51,52) 38 3EZB A-B:1 [A-B]>A: E68+AI(71,72)+EGHML(74-79)+EL(84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) [A-B]>B: LHTR(314-317)+AA(319,320)+VK(323,324)+K327+KSLF(345-348)+QT(351,352) 39 3EZE A-B:1 [A-B]>A: EE(67,68)+A71+EQHML(74-79)+DEL(82,84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) [A-B]>B: LHTR(314-317)+A320+VK(323,324)+K327+KSLF(345-348)+QT(351,352) 40 1EV2 A-E:1, B-F:2, C-G:3, D-H:4, A-H:5, B-G:6, B-H:7, C-E:8, C-F:9, D-E:10, C-H:11 [A-E]>E: EK(163,164)+LHAVP(166-170)+DVRP(247,249,251,253)+VS(280,282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+NS(346,347)+I350 [B-F]>F: EK(163,164)+LHAVP(166-170)+DVRP(247,249,251,253)+VS(280,282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+NS(346,347) [C-G]>G: EK(163,164)+LHAVP(166-170)+DVRP(247,249,251,253)+VS(280,282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+NS(346,347)+I350 [D-H]>H: EK(163,164)+LHAVP(166-170)+DVRP(247,249,251,253)+VS(280,282)+AQPH(284-287)+AGV(315-317)+TD(320,321)+E325+NS(346,347)+I350 [A-H]>H: R255+I348 [B-G]>G: R255+I348 [B-H]>H: D273+Y328+RN(330,331) [C-E]>E: EK(197,199) [C-F]>F: I348 [D-E]>E: I348 [C-H]>H: L360+P363 [A-E]>A: FK(17,18)+K21+YKG(24,26,28)+F31+R44+LQAEER(55-60)+VS(63,64)+Y73+V88+EL(96,98)+NNYN(101-104)+LPM(140-142) [B-F]>B: FK(17,18)+K21+YKGGF(24,26,28,29,31)+R44+LQAEER(55-60)+VS(63,64)+Y73+V88+EL(96,98)+NNYN(101-104)+LPM(140-142) [C-G]>C: FK(17,18)+YKGGF(24,26,28,29,31)+R44+LQAEER(55-60)+VS(63,64)+V88+EL(96,98)+NYN(102-104)+LPM(140-142) [D-H]>D: FK(17,18)+YKGGF(24,26,28,29,31)+R44+LQAEER(55-60)+VS(63,64)+EL(96,98)+NNYN(101-104)+LPM(140-142) [A-H]>A: S100 [B-G]>B: S100 [B-H]>B: FRE(95,97,99)+R107+Y115+P132 [C-E]>C: D90+K110 [C-F]>C: S100 [D-E]>D: S100 [C-H]>C: PG(132,133) 41 1II4 A-E:1, B-F:2, C-G:3, D-H:4, A-G:5, A-H:6, B-G:7, C-F:8, D-E:9, D-F:10, D-G:11 [A-E]>E: EK(163,164)+LHAVP(166-170)+D247+VERS(249-252)+VYS(280-282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [B-F]>F: EK(163,164)+LHAVP(166-170)+D247+VERSP(249-253)+VYS(280-282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347) [C-G]>G: EK(163,164)+LHAVP(166-170)+D247+VERSP(249-253)+I257+KVYS(279-282)+AQPH(284-287)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [D-H]>H: EK(163,164)+LHAVP(166-170)+D247+VERSP(249-253)+I257+VYS(280-282)+AQPH(284-287)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [A-G]>G: D273+R330+Y328 [A-H]>H: R255+I348 [B-G]>G: R255+I348 [C-F]>F: I348 [D-E]>E: I348 [D-F]>F: EK(197,199) [D-G]>G: L360 [A-E]>A: FP(21,22)+GHFK(24-27)+K30+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+VS(72,73)+Y82+V97+E105+L107+NNYN(110-113)+LPM(149-151) [B-F]>B: FP(21,22)+GHFK(24-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+VS(72,73)+Y82+V97+E105+L107+NNYN(110-113)+LPM(149-151) [C-G]>C: FP(21,22)+GHFK(24-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+V72+E105+L107+NNYN(110-113)+LPM(149-151) [D-H]>D: FP(21,22)+GHFK(24-27)+Y30+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+V72+E105+L107+NNYN(110-113)+LPM(149-151) [A-G]>A: R106+R116+P141 [A-H]>A: SN(109,111) [B-G]>B: SN(109,111) [C-F]>C: S109 [D-E]>D: S109 [D-F]>D: D99+K119 [D-G]>D: P141 42 1IIL A-E:1, B-F:2, A-G:3, A-H:4, B-G:5, C-F:6, D-E:7, C-G:8, D-H:9, D-F:10, D-G:11 [A-E]>E: EK(163,164)+LHAVP(166-170)+N173+VERSR(249-253)+VYS(280-282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [B-F]>F: EK(163,164)+LHAVP(166-170)+N173+D247+VERSR(249-253)+VYS(280-282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [A-G]>G: D273+RN(330,331)+Y328 [A-H]>H: HR(254,255)+I348 [B-G]>G: HR(254,255)+I348 [C-F]>F: HR(254,255)+I348 [D-E]>E: HR(254,255)+I348 [C-G]>G: EK(163,164)+LHAVP(166-170)+N173+D247+RSR(251-253)+VS(280,282)+AQPHI(284-288)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [D-H]>H: EK(163,164)+LHAVP(166-170)+N173+D247+RSR(251-253)+KVS(279,280,282)+AQPH(284-287)+AGV(315-317)+TD(320,321)+E325+GNS(345-347)+I350 [D-F]>F: EK(197,199) [D-G]>G: LAP(360,362,363) [A-E]>A: PP(22,23)+HFK(25-27)+YKGF(33,35,37,40)+R53+LQAEER(64-69)+VS(72,73)+Y82+V97+E105+LESNNYN(107-113)+LPM(149-151) [B-F]>B: PP(22,23)+HFK(25-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+VS(72,73)+Y82+V97+E105+LESNNYN(107-113)+LPM(149-151) [A-G]>A: FR(104,106)+R116+TSY(121,122,124)+P141 [A-H]>A: SN(109,111) [B-G]>B: SNN(109-111) [C-F]>C: SNN(109-111) [D-E]>D: SNN(109-111) [C-G]>C: HFK(25-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+V72+E105+LESNNYN(107-113)+LPM(149-151) [D-H]>D: HFK(25-27)+YKGGF(33,35,37,38,40)+R53+LQAEER(64-69)+V72+F102+E105+LESNNYN(107-113)+LPM(149-151) [D-F]>D: D99+K119 [D-G]>D: PG(141,142) 43 2H1P H-P:2, L-P:3 [H-P]>H: F333+KTY(357-359)+R399+A403+L405 [L-P]>L: Q27+VHN(30,31,33)+STHV(96-99)+W101 [H-P]>P: WMLV(608-611) [L-P]>P: LQYT(602-605)+ML(609,610) 44 1G9M G-H:2, G-L:3 [G-H]>H: I52+LVH(55,57,59)+E103+EGEYR(106-110) [G-L]>L: WP(94,95) [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) 45 1G9N G-H:2, G-L:3 [G-H]>H: LVH(55,57,59)+E103+EGEYR(106-110) [G-L]>L: WP(94,95) [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) 46 1RZJ G-H:2, G-L:3 [G-H]>H: LVH(54,56,58)+E99+EGEYDN(100B-110G) [G-L]>L: WP(94,95) [G-H]>G: VL(120,122)+T202+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) 47 1RZK G-H:2, G-L:3 [G-H]>H: LVH(54,56,58)+E99+EGEYD(100B-110F) [G-L]>L: WP(94,95) [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+P437 [G-L]>G: C119+TQ(202,203) 48 2NXY A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+P437 49 2NXZ A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 50 2NY0 A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 51 2NY1 A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 52 2NY2 A-C:2, A-D:3 [A-C]>C: W2094 [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 53 2NY3 A-C:2, A-D:3 [A-C]>C: W2094 [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 54 2NY4 A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+ILVH(3054,3055,3057,3059)+E3103+EGEYDN(3106-3111) [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 55 2NY5 G-H:2, G-L:3 [G-H]>H: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) [G-L]>L: WP(2094,2095) [G-H]>G: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: CV(119,120)+TQC(202,203,205) 56 2NY6 A-C:2, A-D:3 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EG(3106,3107)+YDN(3109-3111) [A-C]>A: C119+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 57 3DOW A-B [A-B]>A: E19+I23+Y27+RPV(30,32,33)+KYLVP(50-54)+L57+F62+LI(65,66)+R69+F106 [A-B]>B: DWDFLPP(5-11) The site residues were obtained through computing contacts by a distance ≤ 4Å. 58 1MQ8 A-B:1, C-D:2 [A-B]>A: K29+IETP(33-36)+K39+QMYN(62,64,66,68)+Q73 [C-D]>C: K29+IETP(33-36)+K39+QMYN(62,64,66,68)+Q73 [A-B]>B: SMS(139-141)+Q143+T175+LLTN(204-207)+EATDS(241-245)+H264 [C-D]>D: SMS(139-141)+Q143+T175+LLTN(204-207)+EATDS(241-245)+H264 59 1WLP A-B:1 [A-B]>B: I164+Y167+S171+E174+E187+SGW(191-193)+F195+WP(204,206)+SF(208,209)+E241+DE(243,244)+W263+PMY(276,278,279) [A-B]>A: SKQPP(5-9)+NPPPRPP(11-17)+EA(19,20) 60 1HX1 A-B:1 [A-B]>B: R205+KA(208,209)+IE(211,212)+MK(215,216)+E219+DTLIL(222-226)+R234+RK(237,238)+VK(241,142)+Q245+D252 [A-B]>A: TD(45,46)+N57+AMN(60-62)+R258+RR(261,262)+T265+R269+S281+EIDS(283-286)+GDY(290,292,294) 61 1ZTX E-H:1, E-L:2 [E-H]>H: YT(27,28)+DYW(31-33)++L52+RR(56,58)+SASYGD(95-100) [E-L]>L: S30+W50+HYTT(91-94) [E-H]>E: Y302+SKAF(306-309)+TTD(330,332,333)+GEQ(389-391) [E-L]>E: TT(330,332)+ATAN(365-368) 62 1N0X H-P:3, H-R:4, K-P:5, K-R:6, L-P:8,M-R:9 [H-P]>H: NKE(56-58)+PQ(100D,100E) [H-R]>H: DDS(100A-100C) [K-P]>K: S100 [K-R]>K: W50+NKE(56-58)+PQ(100D,100E) [L-P]>L: E1+HS(27,28)+I28A+RSR(29,30,32)+S95 [M-R]>M: E1+HS(27,28)+I28A+RSR(29,30,32)+AS(93,95) [H-P]>P: YM(5,6)+Orn19+K20 [H-R]>R: R13 [K-P]>P: N12 [K-R]>R: SYM(4-6)+E18+Orn19+K20 [L-P]>P: FDLN(7,9,10,12) [M-R]>R: MFDL(6,7,9,10)+I15 63 2DSQ C-G:5, C-H:6, G-I:7 [C-G]>G: QI(227,228) [C-H]>H: R152+LY(155,156)+V159+FLPNCNKG(176,178-183,185)+C192 [G-I]>G: R152+LY(155,156)+FLPNNKG(176,178-180,182,183,185)+RC(190,192)+TM(194,196)+E199 [C-G]>C: D20 [C-H]>C: CGA(6-8)+FN(25,26)+VD(44,45)+F49 [G-I]>I: CGAEVD(6-9,11,12)+Q15+F25+VD(44,45)+CF(48+,49) 64 1YCR A-B:1 [A-B]>A: ET(25,26)+MK(50,51)+L54+G58+IM(61,62)+QHV(72,73,75)+VKH(93,94,96)+Y100+Y104 [A-B]>B: ETFSLWLLPEN(17-20,22,23,25-29) 65 1P9M A-B:1, B-C:3 [A-B]>B: L19+R24+K27+Q28+Y31+D34+RA(113,114)+F125 [B-C]>B: R30+K54+CFQ(73-75)+Q175+LRARQ(178-180,182,183) [A-B]>A: W142+S165+YFVN(168-171)+D193+SV(229,230) [B-C]>C: EG(163,164)+F168+SFYR(228-231)+EFQ(278,279,281) 66 3MG5 A-BTN5100(A), B-BTN5200(B), C-BTN5200(B), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [C-BTN5200(B)]>C: W120 [C-BTN5300(C)]>C: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [D-BTN5400(D)]>D: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 67 2HYM A-B:1 [A-B]>A: MSKPED(46-51)+HEA(77,78,80)+SH(96,97)+W100+DLS(138-140)+K159+EH(186,187) [A-B]>B: LFCLKRD(26,27,29-31,33,35)+RA(144,145)+R149+SL(152,153)+RSE(162,163,165) 68 1HQL A-GLA401(A), B-GLA401(B) [A-GLA401(A)]>A: W47+AD(87,88)+E106+N134+GNN(221-223) [B-GLA401(B)]>B: W47+AD(87,88)+E106+WN(132,134)+GNN(221-223)+Mbg402 69 1FC2 C-D:1 [C-D]>D: LMIS(251-254)+LHQ(309-311)+L314+LHNH(432-435) [C-D]>C: F124+QQNFY(129,130,132,133)+L136+N147+I150+LK(153,154) 70 1A2C H-I [H-I]>H: PKQ(34,36,38)+L40+LR(65,67)+RTRY(73-76)+KIM(81,82,84) [H-I]>I: DFEEIP(355-360)+Tys363+L364 The site residues were obtained through computing contacts by a distance ≤ 4Å. 71 1A46 H-I [H-I]>H: PKQ(34,36,38)+L40+LR(65,67)+RTRYE(73-77)+R77A+EKIM(80-82,84) [H-I]>I: DFEEIP(355-360)+Tys363+L364 The site residues were obtained through computing contacts by a distance ≤ 4Å. 72 1A5G H-I [H-I]>H: FKQ(34,36,38)+L40+LR(65,67)+RTRY(73-76)+R77A+EKIM(80-82,84) [H-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 73 1A61 H-I [H-I]>H: FKQ(34,36,38)+L40+LR(65,67)+RTRY(73-76)+EKIM(80-82,84) [H-I]>I: DFEEIP(355-360)+Tys363+L364 The site residues were obtained through computing contacts by a distance ≤ 4Å. 74 1B5G H-I [H-I]>H: FKQL(34,36,38,40)+LR(65,67)+RTRY(73-76)+EKIM(80-82,84) [H-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 75 1K21 H-I [H-I]>H: FKQL(34,36,38,40)+LR(65,67)+RTRY(73-76)+EKIM(80-82,84) [H-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 76 1K22 H-I [H-I]>H: F34+QL(38,40)+LR(65,67)+RTRY(73-76)+EKIM(80-82,84) [H-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 77 1NRS H-I [H-I]>H: F34+QL(38,40)+LR(65,67)+RTRY(73-76)+R77A+KIM(81,82,84) [H-I]>I: DFEEIP(55-60)+Tys63 The site residues were obtained through computing contacts by a distance ≤ 4Å. 78 1VZQ H-I [H-I]>H: F34+QEL(38-40)+LR(65,67)+RTRY(73-76)+I82+Q151 [H-I]>I: DFEEIP(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 79 1W7G H-I [H-I]>H: F34+QEL(38-40)+L65+RTRY(73-76)+R77A+IM(82,84) [H-I]>I: DFEEIP(55-60)+YL(63,64) The site residues were obtained through computing contacts by a distance ≤ 4Å. 80 1WAY B-I [B-I]>B: FKQL(34,36,38,40)+LR(65,67)+RTRYR(73-77)+EKI(80-82)+Q151 [B-I]>I: DFEEIP(55-60)+YL(63,64) The site residues were obtained through computing contacts by a distance ≤ 4Å. 81 2C8W B-I [B-I]>B: F34+QL(38,40)+LR(65,67)+RTRY(73-76)+EKIM(80-82,84)+Q151 [B-I]>I: DFEEIPE(55-60,62)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 82 2C8X B-I [B-I]>B: FkQL(34,36,38,40)+LR(65,67)+RTRY(73-76)+EKI(80-82) [B-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 83 2C8Y B-I [B-I]>B: FkQL(34,36,38,40)+LR(65,67)+RTRY(73-76)+R77A+EKI(80-82)+Q151 [B-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 84 2C8Z B-I [B-I]>B: FKQEL(34,36,38-40)+LR(65,67)+RTRY(73-76)+R77A+EKI(80-82) [B-I]>I: DFEEIP(55-60)+Tys63 The site residues were obtained through computing contacts by a distance ≤ 4Å. 85 2C90 B-I [B-I]>B: FKQL(34,36,38,40)+LR(65,67)+RTRYR(73-77)+R77A+KI(81,82)+Q151 [B-I]>I: DFEIP(55-57,59,60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 86 2C93 B-I [B-I]>B: FKQL(34,36,38,40)+LR(65,67)+RTRY(73-76)+R77A+EKI(80-82) [B-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 87 2R2M B-H [B-H]>B: FK(55,57)+QL(61,62)+LR(96,98)+RTRY(104-107)+KIM(113,114,116) [B-H]>H: DFEEIPEYLQ(290-295,297-300) The site residues were obtained through computing contacts by a distance ≤ 4Å. 88 2ZFQ H-I [H-I]>H: F34+QL(38,40)+LR(65,67)+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+Tys63 The site residues were obtained through computing contacts by a distance ≤ 4Å. 89 2ZFR H-I [H-I]>H: F34+QL(38,40)+LR(65,67)+RTRY(73-76)+EKI(80-82) [H-I]>I: GDFEEIP(54-60)+Tys63 The site residues were obtained through computing contacts by a distance ≤ 4Å. 90 2ZG0 H-I [H-I]>H: FKQEL(34,36,38-40)+LR(65,67)+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 91 2ZHE H-I [H-I]>H: FKQL(34,36,38,40)+LR(65,67)+RTRY(73-76)+R77A+EKI(80-82)+M84 [H-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 92 2ZHF H-I [H-I]>H: F34+QEL(38-40)+LR(65,67)+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 93 2ZHW H-I [H-I]>H: F34+L40+LR(65,67)+RTRY(73-76)+EKIM(80-82,84) [H-I]>I: DFEIP(55-57,59,60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 94 3BIU H-I [H-I]>H: FKQL(34,36,38,40)+LR(65,67)+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 95 3BIV H-I [H-I]>H: FKQL(34,36,38,40)+LR(65,67)+RTRY(73-76)+EKI(80-82)+M84 [H-I]>I: DFEEIPE(55-60,62)+Tys63+L64 The site residues were obtained through computing contacts by a distance ≤ 4Å. 96 3F68 H-I [H-I]>H: F34+QEL(38-40)+LR(65,67)+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+Tys63 The site residues were obtained through computing contacts by a distance ≤ 4Å. 97 3HTC No contacts found by a distance ≤ 4Å. 98 4HTC H-I [H-I]>H: FRKQELL(34-36,38-41)+S36A+H57+YPWK(60A,60C,60F)+LR(65,67)+RTRY(73-76)+R77A+IM(82,84)+W96+E97A+L99+WGN(141-143)+EW(146,148)+K149E+Q151+TRI(172-174)+ACE(190-192)+S195+VSWG(213-216) [H-I]>I: ITYTD(1-5)+LLESNV(13,15,17,19-21)+K24+C39+PKESHNNGDFEEIP(46,47,49-60)+YLQ(63-65) The site residues were obtained through computing contacts by a distance ≤ 4Å. 99 1YCR A-B:1 [A-B]>A: ET(25,26)+MK(50,51)+L54+G58+IM(61,62)+QH(72,73)+V75+VK(93,94)+H96+Y100+Y104 [A-B]>B: ETFSLWLLPEN(17-20,22,23,25-29) 100 3EQS A-B:1 [A-B]>A: L54+LG(57,58)+IM(61,62)+Y67+QH(72,73)+V93+H96+Y100 [A-B]>B: SF(2,3)+YWLLS(6,7,9-11) 101 3LNZ A-B:1, C-D:2, E-F:3, I-J:4, M-N:5, O-P:6, A-N:11, B-G:12, E-H:15, F-G:16, G-H:17, K-L:18, [A-B]>A: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+V93+H96+Y100 [C-D]>C: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+Y100 [E-F]>E: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+V93+H96+IY(99,100) [I-J]>I: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+Y100 [M-N]>M: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+IY(99,100) [O-P]>O: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+IY(99,100) [A-N]>A: P89 [B-G]>G: P89 [E-H]>E: FY(55,56)+Q59 [F-G]>G: E52+FY(55,56)+Q59 [G-H]>G: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+VKH(93,94,96)+IY(99,100) [K-L]>K: L54+LG(57,58)+IM(61,62)+Y67+QHV(72,73,75)+V93+H96+Y100 [A-B]>B: TSF(1-3)+YWLL(6,7,9,10) [C-D]>D: TSF(1-3)+YW(6,7)+L10 [E-F]>F: TSF(1-3)+YWLLS(6,7,9-11) [I-J]>J: TSFAYWLLS(1-4,6,7,9-11) [M-N]>N: TSF(1-3)+YWLLS(6,7,9-11) [O-P]>P: SF(2,3)+YWLL(6,7,9,10) [A-N]>N: L10 [B-G]>B: L10 [E-H]>H: SFAE(2-5)+A8 [F-G]>F: TSFAE(1-5)+A8 [G-H]>H: TSF(1-3)+YWLLSP(6,7,9-12) [K-L]>L: TSF(1-3)+YWLLSP(6,7,9-12) 102 3G03 A-B:1, C-D:2 [A-B]>A: L54+LG(57,58)+IM(61,62)+Y67+QH(72,73)+VKH(93,94,96)+Y100 [C-D]>C: K51+L54+LG(57,58)+IM(61,62)+Y67+QH(72,73)+VKH(93,94,96)+Y100 [A-B]>B: LTFEYW(17-20,22,23)+L26 [C-D]>D: TFEYWQLT(18-20,22,23,25-27) 103 3JZR A-P:1 [A-P]>A: GS(16,17)+Q24+L54+LGQIM(57-59,61,62)+Y67+QH(72,73)+VKH(93,94,96)+I99 [A-P]>P: LTFEWWQLTS(17-20,22,23,25-28) 104 3JZS A-P:1 [A-P]>A: K51+LFLG(54,55,57,58)+IM(61,62)+Y67+QH(72,73)+VK(93,94)+H96 [A-P]>P: ETFEWW(1-4,6,7)+LL(10,11) 105 3DAB A-B:1, C-D:3, E-F:6, F-G:8, G-H:9 [A-B]>A: VK(49,50)+M53+G57+IM(60,61)+QH(71,72)+V92+P95+LY(98,99) [C-D]>C: M53+LG(56,57)+I60+Y66+QH(71,72)+V92+P95+LY(98,99) [E-F]>E: M53+G57+I60+Y66+QEQH(69-72)+VKP(92,93,95)+LY(98,99) [F-G]>G: G78+E83 [G-H]>G: VK(49,50)+M53+LG(56,57)+IM(60,61)+Y66+QHV(71,72,74)+V92+P95+LY(98,99) [A-B]>B: ETFLW(17-19,22,23)+LPE(26-28) [C-D]>D: ETF(17-19)+LW(22,23)+LP(26,27) [E-F]>F: QETF(16-19)+LW(22,23)+LP(26,27) [F-G]>F: TFS(18-20) [G-H]>H: FESLW(18-20,22,23)+LPE(26-28) 106 3EQY A-C:2, B-D:3, B-C:4 [A-C]>A: V49+M53+LG(56,57)+IM(60,61)+Y66+QH(71,72)+V92+P95+Y99 [B-D]>B: V49+M53+LG(56,57)+IM(60,61)+Y66+QH(71,72)+V92+P95+Y99 [B-C]>B: AA(69,70) [A-C]>C: TSF(1-3)+YW(6,7)+LSP(10-12) [B-D]>D: TSF(1-3)+YW(6,7)+LSP(10-12) [B-C]>C: A4+N8 107 3FDO A-B:1 [A-B]>A: M53+LG(56,57)+IM(60,61)+Y66+QH(71,72)+VK(92,93)+LY(98,99) [A-B]>B: LTF(17-19)+YW(22,23)+LT(26,27) 108 3JZO A-P:1 [A-P]>A: K50+M53+LG(56,57)+IM(60,61)+Y66+QHV(71,72,74)+VK(92,93)+LY(98,99) [A-P]>P: LTFEYW(1-4,6,7)+LTS(10-11) 109 3JZP A-P:1 [A-P]>A: K50+M53+G57+IM(60,61)+Y66+QHV(71,72,74)+VK(92,93)+LY(98,99) [A-P]>P: LTFEWW(17-20,22,23)+LTS(26-28) 110 3JZQ A-P:2, B-Q:3 [A-P]>A: K50+M53+LG(56,57)+IM(60,61)+Y66+QH(71,72)+VKP(92,93,95)+LY(98,99) [B-Q]>B: VK(49,50)+M53+G57+I60+Y66+QH(71,72)+VK(92,93)+P95+LY(98,99) [A-P]>P: ETF(1-3)+WW(6,7)+LL(10,11) [B-Q]>Q: ETF(1-3)+WW(6,7)+LLS(10-12) 111 1G9M G-H:2, G-L:3 [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) [G-H]>H: I52+LVH(55,57,59)+E103+EGEYR(106-110) [G-L]>L: WP(94,95) 112 1G9N G-H:2, G-L:3 [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) [G-H]>H: LVH(55,57,59)+E103+EGEYR(106-110) [G-L]>L: WP(94,95) 113 1GC1 G-H:2, G-L:3 [G-H]>G: K121+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203)+M434 [G-H]>H: LVH(55,57,59)+E103+EGEYDN(106-111) [G-L]>L: WP(94,95) 114 1RZJ G-H:2, G-L:3 [G-H]>G: VL(120,122)+T202+R419+KQI(421-423)+M434+P437 [G-L]>G: C119+TQ(202,203) [G-H]>H: LVH(54,56,58)+E99+EGEYDN(100B-110G) [G-L]>L: WP(94,95) 115 1RZK G-H:2, G-L:3 [G-H]>G: VL(120,122)+VT(200,202)+R419+KQI(421-423)+P437 [G-L]>G: C119+TQ(202,203) [G-H]>H: LVH(54,56,58)+E99+EGEYD(100B-110F) [G-L]>L: WP(94,95) 116 2NXY A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+P437 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) 117 2NXZ A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) 118 2NY0 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 [A-C]>C: WP(2094,2095) [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) 119 2NY1 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) 120 2NY2 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+T202+R419+KQI(421-423)+M434+P437 [A-C]>C: W2094 [A-D]>D: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) 121 2NY3 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [A-C]>C: W2094 [A-D]>D: I3052+LVH(3055,3057,3059)+E3103+EGEYD(3106-3110) 122 2NY4 A-C:2, A-D:3 [A-C]>A: CV(119,120)+TQ(202,203) [A-D]>A: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [A-C]>C: WP(2094,2095) [A-D]>D: I3052+ILVH(3054,3055,3057,3059)+E3103+EGEYDN(3106-3111) 123 2NY5 G-H:2, G-L:3 [G-H]>G: L122+VT(200,202)+R419+KQI(421-423)+M434+P437 [G-L]>G: CV(119,120)+TQC(202,203,205) [G-H]>H: LVH(3055,3057,3059)+E3103+EGEYDN(3106-3111) [G-L]>L: WP(2094,2095) 124 2C9F A-S, A-T, A-W, B-S, B-T, C-T, C-U, D-U, D-V, E-V, E-W [A-S]>A: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-T]>A: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-W]>A: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [B-S]>B: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [B-T]>B: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [C-T]>C: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [C-U]>C: R197+E203+K385+LTH(490-492)+NRFPE(495-499) [D-U]>D: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [D-V]>D: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [E-V]>E: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [E-W]>E: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-S]>S: FNPVYPYDT(11-19) [A-T]>T: FNPVYPYDT(11-19) [A-W]>W: TFNPYYD(10-13,15,17,18) [B-S]>S: TFNPYYD(10-13,15,17,18) [B-T]>T: FNPVYPYDT(11-19) [C-T]>T: TFNPYYD(10-13,15,17,18) [C-U]>U: FNPVYPYDT(11-19) [D-U]>U: TFNPYYD(10-13,15,17,18) [D-V]>V: FNPVYPYDT(11-19) [E-V]>V: TFPYYD(10,11,13,15,17,18) [E-W]>W: FNPVYPYDT(11-19) The site residues were obtained through computing contacts by a distance ≤ 4Å. 125 2C9F A-S, A-T, A-W, B-S, B-T, C-T, C-U, D-U, D-V, E-V, E-W [A-S]>S: FNPVYPYDT(11-19) [A-T]>T: FNPVYPYDT(11-19) [A-W]>W: TFNPYYD(10-13,15,17,18) [B-S]>S: TFNPYYD(10-13,15,17,18) [B-T]>T: FNPVYPYDT(11-19) [C-T]>T: TFNPYYD(10-13,15,17,18) [C-U]>U: FNPVYPYDT(11-19) [D-U]>U: TFNPYYD(10-13,15,17,18) [D-V]>V: FNPVYPYDT(11-19) [E-V]>V: TFPYYD(10,11,13,15,17,18) [E-W]>W: FNPVYPYDT(11-19) [A-S]>A: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-T]>A: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [A-W]>A: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [B-S]>B: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [B-T]>B: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [C-T]>C: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [C-U]>C: R197+E203+K385+LTH(490-492)+NRFPE(495-499) [D-U]>D: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [D-V]>D: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) [E-V]>E: DVT(220,222,223)+MP(227,228)+LV(287,289)+YQ(292,293)+K374 [E-W]>E: V189+YL(192,193)+R197+E203+K385+LTH(490-492)+NRFPE(495-499) The site residues were obtained through computing contacts by a distance ≤ 4Å. 126 1AVD A-BTN400(A), B-BTN401(B) [A-BTN400(A)]>A: NLS(12,14,16)+YTVAT(33,35,37,39,40)+W70+SST(73,75,77)+W97+W110+N118 [B-BTN401(B)]>B: N12+S16+YTVTAT(33,35,37-40)+WFSST(70,72,73,75,77)+W97+N118 127 2C4I A-BTN1274(A), A-BTN1275(A) [A-BTN1274(A)]>A: WFSST(15,17,18,20,22)+W42+W55+N63+N91+S95+YTVTAT(112,114,116-119) [A-BTN1275(A)]>A: ST(141,143)+W176+N184+NLS(212,214,216)+YTVTAT(233,235,237-240)+W270+S273 128 2JGS A-BTN1001(A), B-BTN1001(A), A-BTN1001(B), B-BTN1001(B), C-BTN1001(C), D-BTN1001(C), C-BTN1001(D), D-BTN1001(D) [A-BTN1001(A)]>A: W28+SST(31,33,35)+W55+M76+S108+YTV(125,127,129) [B-BTN1001(A)]>B: W68 [A-BTN1001(B)]>A: W68 [B-BTN1001(B)]>B: W28+SST(31,33,35)+W55+M76+S108+YTV(125,127,129) [C-BTN1001(C)]>C: W28+SST(31,33,35)+W55+M76+S108+YTVT(125,127,129,130) [D-BTN1001(C)]>D: W68 [C-BTN1001(D)]>C: W68 [D-BTN1001(D)]>D: R17+W28+FSST(30,31,33,35)+W55+M76+S108+YT(125,127)+T130 129 1DF8 A-BTN201(A), B-BTN202(B) [A-BTN201(A)]>A: NLS(23,25,27)+Y43+VN(47,49)+W79+S88+T90+WL(108,110)+D128 [B-BTN202(B)]>B: NLS(23,25,27)+Y43+VN(47,49)+W79+S88+T90+W108+D128 130 1LUQ A-BTN5100(A), A-BTN5200(B), B-BTN5200(B) [A-BTN5100(A)]>A: NLS(1023,1025,1027)+Y1043+VGN(1047-1049)+ST(1088,1090)+WL(1108,1110)+D1128 [A-BTN5200(B)]>A: W120 [B-BTN5200(B)]>B: NLS(2023,2025,2027)+Y2043+VGN(2047-2049)+W2079+AST(2086,2088,2090)+W2108+D2128 131 1MEP A-BTN5100(A), D-BTN5100(A), B-BTN5200(B), C-BTN5200(B), B-BTN5300(C), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: N23+S27+Y43+VN(47,49)+W79+ST(88,90)+WL(108,110) [D-BTN5100(A)]>D: W120 [B-BTN5200(B)]>B: NLS(23,25,27)+Y43+VGN(47-49)+W79+S88+T90+W108 [C-BTN5200(B)]>C: W120 [B-BTN5300(C)]>B: W120 [C-BTN5300(C)]>C: N23+S27+Y43+VGN(47-49)+W79+S88+T90+W108+L110 [D-BTN5400(D)]>D: N23+S27+Y43+VGN(47-49)+W79+AST(86,88,90)+W108 132 1MK5 A-BTN5100(A), B-BTN5100(A), A-BTN5200(B), B-BTN5200(B) [A-BTN5100(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+S88+T90+W108+D128 [B-BTN5100(A)]>B: W120 [A-BTN5200(B)]>A: W120 [B-BTN5200(B)]>B: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+WL(108,110)+D128 133 1N43 A-BTN5100(A), B-BTN5200(B), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: S27+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: LS(25,27)+YS(43,45)+GN(48,49)+W79+ST(88,90)+W108+D128 [C-BTN5300(C)]>C: S27+YSVGN(43,45,47-49)+W79+STW(88,90,92)+W108+D128 [D-BTN5400(D)]>D: LS(25,27)+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 134 1N9M A-BTN5100(A), B-BTN5200(B), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: NLA(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: NLA(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [C-BTN5300(C)]>C: NLA(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [D-BTN5400(D)]>D: NLA(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 135 1NDJ A-BTN5100(A), D-BTN5100(A), B-BTN5200(B), C-BTN5200(B), B-BTN5300(C), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: N23+S27+FSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 [D-BIN5100(A)]>D:W120 [B-BTN5200(B)]>B: NLS(23,25,27)+FSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [C-BTN5200(B)]>C: W120 [B-BTN5300(C)]>B: W120 [C-BTN5300(C)]>C: NLS(23,25,27)+FSVN(43,45,47,49)+W79+STW(88,90,92)+WL(108,110)+D128 [D-BTN5400(D)]>D: NLS(23,25,27)+FSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 136 1NQM A-BTN150(A), B-BTN150(A), A-BTN350(B), B-BTN350(B), C-BTN550(C), D-BTN550(C), C-BTN750(D), D-BTN750(D) [A-BTN150(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN150(A)]>B: K320 [A-BTN350(B)]>A: K120 [B-BTN350(B)]>B: N223+S227+YSVN(243,245,247,249)+W279+ST(288,290)+W308+D328 [C-BTN550(C)]>C: N423+S427+YSVN(443,445,447,449)+W479+ST(488,490)+W508+D528 [D-BTN550(C)]>D: K720 [C-BTN750(D)]>C: K520 [D-BTN750(D)]>D: N623+S627+WSVN(643,645,647,649)+W679+ST(688,690)+W708+D728 137 1STP A-BTN300(A) [A-BTN300(A)]>A: N23+S27+YSVN(43,45,47,49)+W79+AST(86,88,90)+WW(108,120)+D128 138 1SWD A-BTN300(A), D-BTN300(A), A-BTN600(D), D-BTN600(D) [A-BTN300(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ASTW(86,88,90,92)+W108+D128 [D-BTN300(A)]>D: W120 [A-BTN600(D)]>A: A120 [D-BTN600(D)]>D: NLS(23,25,27)+Y43+VGN(47-49)+W79+ASTW(86,88,90,92)+WL(108,110)+D128 139 1SWE A-BTN300(A), B-BTN400(B), B-BTN500(C), C-BTN500(C), A-BTN600(D), D-BTN600(D) [A-BTN300(A)]>A: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN400(B)]>B: N23+S27+YSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 [B-BTN500(C)]>B: W120 [C-BTN500(C)]>C: NLS(23,25,27)+YS(43,45)+GN(48,49)+W79+STW(88,90,92)+W108+D128 [A-BTN600(D)]>A: W120 [D-BTN600(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 140 1SWG A-BTN600(A), D-BTN600(A), B-BTN700(B), C-BTN700(B), C-BTN800(C), A-BTN900(D), D-BTN900(D) [A-BTN600(A)]>A: NLS(23,25,27)+YS(43,45)+W79+ASTW(86,88,90,92)+W108+D128 [D-BTN600(A)]>D: W120 [B-BTN700(B)]>B: NLS(23,25,27)+YS(43,45)+W79+AST(86,88,90)+WL(108,110)+D128 [C-BTN700(B)]>C: W120+AS(138,139) [C-BTN800(C)]>C: NLS(23,25,27)+YS(43,45)+W79+ASTW(86,88,90,92)+WL(108,110)+D128 [A-BTN900(D)]>A: W120 [D-BTN900(D)]>D: NLS(23,25,27)+YS(43,45)+W79+STW(88,90,92)+W108+D128 141 1SWK A-BTN5100(A), B-BTN5200(B), C-BTN5200(B), A-BTN5400(D), D-BTN5400(D) [A-BTN5100(A)]>A: N23+S27+YSVGN(43,45,47-49)+W79+ASTW(86,88,90,92)+W108+D128 [B-BTN5200(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 [C-BTN5200(B)]>C: W120 [A-BTN5400(D)]>A: W120 [D-BTN5400(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 142 1SWN A-BTN300(A), C-BTN500(C), D-BTN600(D) [A-BTN300(A)]>A: N23+S27+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [C-BTN500(C)]>C: N23+S27+YSVN(43,45,47,49)+W79+S88+D128 [D-BTN600(D)]>D: N23+S27+YSVN(43,45,47,49)+W79+ST(88,90)+D128 143 1SWP A-BTN300(A), B-BTN400(B), D-BTN600(D) [A-BTN300(A)]>A: NLS(23,25,27)+YSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 [B-BTN400(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 [D-BTN600(D)]>D: NLS(23,25,27)+YSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 144 1SWR A-BTN300(A), D-BTN300(A), B-BTN400(B), C-BTN400(B), B-BTN500(C), C-BTN500(C), A-BTN600(D), D-BTN600(D) [A-BTN300(A)]>A: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN300(A)]>D: K121 [B-BTN400(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [C-BTN400(B)]>C: K121 [B-BTN500(C)]>B: K121 [C-BTN500(C)]>C: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [A-BTN600(D)]>A: K121 [D-BTN600(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 145 1SWT A-BTN500(A), B-BTN600(B) [A-BTN500(A)]>A: N23+S27+YSVN(43,45,47,49)+W79+ST(88,90) [B-BTN600(B)]>B: N23+S27+YS(43,45)+N49+ST(88,90) 146 2F01 A-BTN5100(A), B-BTN5200(B) [A-BTN5100(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: NLS(23,25,27)+YSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 147 2GH7 A-BTN5100(A), B-BTN5200(B) [A-BTN5100(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 148 2IZF B-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [D-BTN301(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 149 2IZG B-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN301(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 150 2IZH B-BTN300(B), B-BTN300(D), D-BTN300(D) [B-BTN300(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [B-BTN300(D)]>B: W120 [D-BTN300(D)]>D: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 151 2IZI A-BTN300(A) [A-BTN300(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+STW(88,90,92)+WL(108,110)+D128 152 2IZJ A-BTN300(A) [A-BTN300(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+W120+D128 153 2RTD B-BTN300(B), D-BTN300(B), D-BTN300(D) [B-BTN300(B)]>B: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN300(B)]>D: W120 [D-BTN300(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 154 2RTE B-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN301(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 155 2RTF B-BTN300(B), D-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN300(B)]>D: W120 [D-BTN301(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 156 2RTG B-BTN300(B), D-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN300(B)]>D: W120 [D-BTN301(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 157 2Y3F A-BTN1136(A) [A-BTN1136(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+W120+D128 158 3MG5 A-BTN5100(A), B-BTN5200(B), C-BTN5200(B), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [C-BTN5200(B)]>C: W120 [C-BTN5300(C)]>C: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [D-BTN5400(D)]>D: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 159 1VWF B-P [B-P]>B: LS(25,27)+SAV(45-47)+SY(52,54)+W79+R84+ST(88,90)+WL(108,110) [B-P]>P: CHPQGPPC(1-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 160 1VWG B-P [B-P]>B: WL(8,10)+L25+D28+YSAV(43,45-47)+SY(52,54)+W79+RASTW(84,86,88,90,92) [B-P]>P: CHPQGPPC(1-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 161 1VWH B-P [B-P]>B: LS(25,27)+YSAVN(43,45-47,49)+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQGPPC(1-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 162 1VWI B-M, D-P [B-M]>B: NLS(23,25,27)+YSAV(43,45-47)+Y54+W79+ASTW(86,88,90,92)+WL(108,110)+D128 [D-P]>D: NLS(23,25,27)+YSAV(43,45-47)+Y54+W79+RASTW(84,86,88,90,92)+WL(108,110) [B-M]>M: HPQGPP(3-8) [D-P]>P: C1+HPQGPP(3-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 163 1VWJ B-M, D-P [B-M]>B: NLS(23,25,27)+YSAV(43,45-47)+Y54+W79+ASTW(86,88,90,92)+WLS(108,110,112)+L124+D128 [D-P]>D: NLS(23,25,27)+YSAV(43,45-47)+Y54+W79+RASTW(84,86,88,90,92)+WL(108,110) [B-M]>M: HPQGPP(3-8) [D-P]>P: CHPQGPP(1,3-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 164 1VWK B-M, D-P [B-M]>B: L25+YSAV(43,45-47)+Y54+W79+RASTW(84,86,88,90,92)+WLS(108,110,112)+L124+D128 [D-P]>D: L25+S27+YSAV(43,45-47)+Y54+W79+ASTW(86,88,90,92)+WL(108,110)+D128 [B-M]>M: HPQGPP(3-8) [D-P]>P: CHPQGPP(1,3-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 165 1VWL B-M,D-P [B-M]>B: NLS(23,25,27)+YSAV(43,45-47)+Y54+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [D-P]>D: LS(25,27)+YSAV(43,45-47)+Y54+W79+ASTW(86,88,90,92)+WL(108,110) [B-M]>M: HPQGPP(3-8) [D-P]>P: CHPQGPP(1,3-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 166 1VWO B-P [B-P]>B: LS(25,27)+YSAVN(43,45-47,49)+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQGPPC(1-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 167 1VWP B-P [B-P]>B: L25+SAVN(45-47,49)+SY(52,54)+W79+RAST(84,86,88,90)+WL(108,110) [B-P]>P: CHPQPPC(1-4,6-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 168 1VWQ B-P [B-P]>B: LGS(25-27)+YSAV(43,45-47)+Y54+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: HPQGPP(3-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 169 1VWR B-P [B-P]>B: LGS(25-27)+YSAV(43,45-47)+Y54+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: HPQGPP(3-8) The site residues were obtained through computing contacts by a distance ≤ 4Å. 170 1SLE B-M, D-P [B-M]>B: L25+SAV(45-47)+Y54+W79+AST(86,88,90)+WL(108,110) [D-P]>D: LS(25,27)+SA(45,46)+Y54+W79+R84+ST(88,90)+WL(108,110) [B-M]>M: HPQGP(2-5,7) [D-P]>P: HPQGPP(2-7) The site residues were obtained through computing contacts by a distance ≤ 4Å. 171 1VWB B-P [B-P]>B: LS(25,27)+YSA(43,45,46)+N49+SY(52,54)+W79+TASTW(84,86,88.90,92)+WL(108,110)+D128 [B-P]>P: CHPQFC(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 172 1VWC B-P [B-P]>B: NLS(23,25,27)+YSA(43,45,46)+N49+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQFC(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 173 1VWD B-P [B-P]>B: LS(25,27)+YSA(43,45,46)+N49+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQFC(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 174 1VWE B-P [B-P]>B: LS(25,27)+YSAV(43,45-47)+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQFC(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 175 1VWM B-P [B-P]>B: LS(25,27)+YSAV(43,45-47)+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQFC(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 176 1VWN B-P [B-P]>B: LS(25,27)+YSAV(43,45-47)+SY(52,54)+W79+RASTW(84,86,88,90,92)+WL(108,110)+D128 [B-P]>P: CHPQFC(1-6) The site residues were obtained through computing contacts by a distance ≤ 4Å. 177 2E9W A-C:2, B-D:3 [A-C]>A: D72+R122+Y125+R181+IKR(201,203,205)+S240+NSWH(260-263)+G265 [B-D]>B: D72+T74+R122+Y125+R181+IKR(201,203,205)+S240+NSWH(260-263)+G265 [A-C]>C: R7+TNN(9-11)+SD(53,54)+T57+L60+DKVN(77,78,80,81)+DD(84,85)+E88+F102 [B-D]>D: R7+TNN(9-11)+SD(53,54)+T57+L60+DKVN(77,78,80,81)+DDVE(84,85,87,88)+K99 178 1DF8 A-BTN201A, B-BTN202B [A-BTN201(A)]>A: NLS(23,25,27)+Y43+VN(47,49)+W79+S88+T90+WL(108,110)+D128 [B-BTN202(B)]>B: NLS(23,25,27)+Y43+VN(47,49)+W79+S88+T90+W108+D128 179 1LUQ A-BTN5100(A), A-BTN5200(B), B-BTN5200(B) [A-BTN5100(A)]>A: NLS(1023,1025,1027)+Y1043+VGN(1047-1049)+ST(1088,1090)+WL(1108,1110)+D1128 [A-BTN5200(B)]>A: W120 [B-BTN5200(B)]>B: NLS(2023,2025,2027)+Y2043+VGN(2047-2049)+W2079+AST(2086,2088,2090)+W2108+D2128 180 1MEP A-BTN5100(A), D-BTN5100(A), B-BTN5200(B), C-BTN5200(B), B-BTN5300(C), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: N23+S27+Y43+VN(47,49)+W79+ST(88,90)+WL(108,110) [D-BTN5100(A)]>D: W120 [B-BTN5200(B)]>B: NLS(23,25,27)+Y43+VGN(47-49)+W79+SW(88,90)+W108 [C-BTN5200(B)]>C: W120 [B-BTN5300(C)]>B: W120 [C-BTN5300(C)]>C: N23+S27+Y43+VGN(47-49)+W79+SW(88,90)+W108+L110 [D-BTN5400(D)]>D: N23+S27+Y43+VGN(47-49)+W79+ASW(86,88,90)+W108 181 1MK5 A-BTN5100(A), B-BTN5100(A), A-BTN5200(B), B-BTN5200(B) [A-BTN5100(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN5100(A)]>B: W120 [A-BTN5200(B)]>A: W120 [B-BTN5200(B)]>B: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+WL(108,110)+D128 182 1N43 A-BTN5100(A), B-BTN5200(B), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: S27+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: LS(25,27)+YS(43,45)+GN(48,49)+W79+ST(88,90)+W108+D128 [C-BTN5300(C)]>C: S27+YSVGN(43,45,47-49)+W79+STW(88,90,92)+W108+D128 [D-BTN5400(D)]>D: LS(25,27)+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 183 1N9M A-BTN5100(A), B-BTN5200(B), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: NLA(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: NLA(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [C-BTN5300(C)]>C: NLA(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [D-BTN5400(D)]>D: NLA(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 184 1NDJ A-BTN5100(A), D-BIN5100(A), B-BTN5200(B), C-BTN5200(B), B-BTN5300(C), C-BTN5300(C), D-BTN5400(D) [A-BTN5100(A)]>A: N23+S27+FSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 [D-BIN5100(A)]>D:W120 [B-BTN5200(B)]>B: NLS(23,25,27)+FSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [C-BTN5200(B)]>C: W120 [B-BTN5300(C)]>B: W120 [C-BTN5300(C)]>C: NLS(23,25,27)+FSVN(43,45,47,49)+W79+STW(88,90,92)+WL(108,110)+D128 [D-BTN5400(D)]>D: NLS(23,25,27)+FSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 185 1NQM A-BTN150(A), B-BTN150(A), A-BTN350(B), B-BTN350(B), C-BTN550(C), D-BTN550(C), C-BTN750(D), D-BTN750(D) [A-BTN150(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN150(A)]>B: K320 [A-BTN350(B)]>A: K120 [B-BTN350(B)]>B: N223+S227+YSVN(243,245,247,249)+W279+ST(288,290)+W308+D328 [C-BTN550(C)]>C: N423+S427+YSVN(443,445,447,449)+W479+ST(488,490)+W508+D528 [D-BTN550(C)]>D: K720 [C-BTN750(D)]>C: K520 [D-BTN750(D)]>D: N623+S627+WSVN(643,645,647,649)+W679+ST(688,690)+W708+D728 186 1STP A-BTN300(A) [A-BTN300(A)]>A: N23+S27+YSVN(43,45,47,49)+W79+AST(86,88,90)+WW(108,120)+D128 187 1SWD A-BTN300(A), D-BTN300(A), A-BTN600(D), D-BTN600(D) [A-BTN300(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ASTW(86,88,90,92)+W108+D128 [D-BTN300(A)]>D: W120 [A-BTN600(D)]>A: A120 [D-BTN600(D)]>D: NLS(23,25,27)+Y43+VGN(47-49)+W79+ASTW(86,88,90,92)+WL(108,110)+D128 188 1SWE A-BTN300(A), B-BTN400(B), B-BTN500(C), C-BTN500(C), A-BTN600(D), D-BTN600(D) [A-BTN300(A)]>A: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN400(B)]>B: N23+S27+YSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 [B-BTN500(C)]>B: W120 [C-BTN500(C)]>C: NLS(23,25,27)+YS(43,45)+GN(48,49)+W79+STW(88,90,92)+W108+D128 [A-BTN600(D)]>A: W120 [D-BTN600(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 189 1SWG A-BTN600(A), D-BTN600(A), B-BTN700(B), C-BTN700(B), C-BTN800(C), A-BTN900(D), D-BTN900(D) [A-BTN600(A)]>A: NLS(23,25,27)+YS(43,45)+W79+ASTW(86,88,90,92)+W108+D128 [D-BTN600(A)]>D: W120 [B-BTN700(B)]>B: NLS(23,25,27)+YS(43,45)+W79+AST(86,88,90)+WL(108,110)+D128 [C-BTN700(B)]>C: W120+AS(138,139) [C-BTN800(C)]>C: NLS(23,25,27)+YS(43,45)+W79+ASTW(86,88,90,92)+WL(108,110)+D128 [A-BTN900(D)]>A: W120 [D-BTN900(D)]>D: NLS(23,25,27)+YS(43,45)+W79+STW(88,90,92)+W108+D128 190 1SWK A-BTN5100(A), B-BTN5200(B), C-BTN5200(B), A-BTN5400(D), D-BTN5400(D) [A-BTN5100(A)]>A: N23+S27+YSVGN(43,45,47-49)+W79+ASTW(86,88,90,92)+W108+D128 [B-BTN5200(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 [C-BTN5200(B)]>C: W120 [A-BTN5400(D)]>A: W120 [D-BTN5400(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 191 1SWN A-BTN300(A), C-BTN500(C), D-BTN600(D) [A-BTN300(A)]>A: N23+S27+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 [C-BTN500(C)]>C: N23+S27+YSVN(43,45,47,49)+W79+S88+D128 [D-BTN600(D)]>D: N23+S27+YSVN(43,45,47,49)+W79+ST(88,90)+D128 192 1SWP A-BTN300(A), B-BTN400(B), D-BTN600(D) [A-BTN300(A)]>A: NLS(23,25,27)+YSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 [B-BTN400(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 [D-BTN600(D)]>D: NLS(23,25,27)+YSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 193 1SWR A-BTN300(A), D-BTN300(A), B-BTN400(B), C-BTN400(B), B-BTN500(C), C-BTN500(C) [A-BTN300(A)]>A: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN300(A)]>D: K121 [B-BTN400(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [C-BTN400(B)]>C: K121 [B-BTN500(C)]>B: K121 [C-BTN500(C)]>C: NLS(23,25,27)+YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 194 1SWT A-BTN500(A), B-BTN600(B) [A-BTN500(A)]>A: N23+S27+YSVN(43,45,47,49)+W79+ST(88,90) [B-BTN600(B)]>B: N23+S27+YS(43,45)+N49+ST(88,90) 195 2F01 A-BTN5100(A), B-BTN5200(B) [A-BTN5100(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: NLS(23,25,27)+YSVN(43,45,47,49)+W79+AST(86,88,90)+W108+D128 196 2GH7 A-BTN5100(A), B-BTN5200(B) [A-BTN5100(A)]>A: NLS(23,25,27)++YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [B-BTN5200(B)]>B: NLS(23,25,27)++YSVN(43,45,47,49)+W79+ST(88,90)+W108+D128 197 2IZF B-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: NLS(23,25,27)++YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 [D-BTN301(D)]>D: NLS(23,25,27)++YSVGN(43,45,47-49)+W79+AST(86,88,90)+W108+D128 198 2IZG B-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: NLS(23,25,27)++YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN301(D)]>D: NLS(23,25,27)++YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 199 2IZH B-BTN300(B), B-BTN300(D), D-BTN300(D) [B-BTN300(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [B-BTN300(D)]>B: W120 [D-BTN300(D)]>D: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 200 2IZI A-BTN300(A) [A-BTN300(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+STW(88,90,92)+WL(108,110)+D128 201 2IZJ A-BTN300(A) [A-BTN300(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+W120+D128 202 2RTD B-BTN300(B), D-BTN300(B), D-BTN300(D) [B-BTN300(B)]>B: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN300(B)]>D: W120 [D-BTN300(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 203 2RTE B-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN301(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 204 2RTF B-BTN300(B), D-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: N23+S27+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN300(B)]>D: W120 [D-BTN301(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 205 2RTG B-BTN300(B), D-BTN300(B), D-BTN301(D) [B-BTN300(B)]>B: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+D128 [D-BTN300(B)]>D: W120 [D-BTN301(D)]>D: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+W108+D128 206 2Y3F A-BTN1136(A) [A-BTN1136(A)]>A: NLS(23,25,27)+YSVGN(43,45,47-49)+W79+ST(88,90)+WL(108,110)+W120+D128 207 1X2R A-B [A-B]>A: Y334+S338+S363+RN(380,382)+N387+R415+I461+F478+R483+SG(508,509)+Y525+Q530+SA(555,556)+YG(572,574)+F577+SG(602,603) [A-B]>B: LEETGEFL(76,78-84) The site residues were obtained through computing contacts by a distance ≤ 4Å. 208 2DYH A-B [A-B]>A: Y334+N382+N387+NR(414,415)+F478+TR(481,483)+SG(508,509)+Y525+SA(555,556)+Y572+F577+SG(602,603) [A-B]>B: WRQDID(24-29) The site residues were obtained through computing contacts by a distance ≤ 4Å. 209 2NR6 A-C:2, B-E:3, A-D:4, B-F:5, A-E:6, B-C:7 [A-C]>A: KP(60,61)+KYSDG(65,66,68,68A,69)+R83 [B-E]>B: KP(60,61)+KYSDG(65,66,68,68A,69)+R83 [A-D]>A: ISDNV(67,68,68A,70,71)+E86+QD(98,100)+ALK(130-132) [B-F]>B: ISDN(67,68,68A,70)+E86+QD(98,100)+ALK(130-132) [A-E]>A: N280 [B-C]>B: N280 [A-C]>C: STA(30-32)+YS(49,50)+Y53+S67+HYN(91-93)+Q96 [B-E]>E: ST(30,31)+YS(49,50)+Y53+S67+HYN(91-93)+Q96 [A-D]>D: KDTYH(30-33,35)+DA(52,54)+R59+WVR(99-101) [B-F]>F: KDTYH(30-33,35)+D52+R59+WVR(99-101) [A-E]>E: I28 [B-C]>C: I28 210 1ILP A-C:2 [A-C]>C: FDD(4-6)+MPPADEDYSP(8-17) [A-C]>A: QIKTYKPF(8,10,11-13,15-17)+HKF(18,20,21)+L43+RELC(47-50) 211 1ILQ A-C:2 [A-C]>C: MDD(1,3,5)+PPDEDYSP(9,10,12-17) [A-C]>A: QIKYK(8,10,11,13,15)+HKF(18,20,21)+I40+LSDREL(43-45,47-49) 212 2XDF A-C:2, B-D:3 [A-C]>C: LHTRAA(614-617,619,620)+VK(623,624)+K627+SLFK(646-649)+Q651+E685 [B-D]>D: LHTRAA(614-617,619,620)+VK(623,624)+K627+SLFK(646-649)+Q651 [A-C]>A: E68+AI(71,72)+EGHML(74-76,78,79)+DE(82,84)+Q111+L115+L123+R126+D129+R279 [B-D]>B: E68+AI(71,72)+EGHML(74-76,78,79)+DE(82,84)+Q111+L115+L123+R126+D129 213 3EZA A-B:1 [A-B]>B: LHTR(14-17)+A20+VK(23,24)+K27+KSLF(45-48)+QT(51,52) [A-B]>A: E68+AI(71,72)+EGHML(74-76,78,79)+DEL(82,84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) 214 3EZB A-B:1 [A-B]>B: LHTRA(314-317,319)+A320+VK(323,324)+K327+KSLF(345-348)+QT(351,352) [A-B]>A: E68+AI(71,72)+EGHML(74-76,78,79)+EL(84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) 215 3EZE A-B:1 [A-B]>B: LHTR(314-317)+A320+VK(323,324)+K327+KSLF(345-348)+QT(351,352) [A-B]>A: EE(67,68)+A71+EGHML(74-76,78,79)+DEL(82,84,85)+Q111+L115+L118+YL(122,123)+R126+DV(129,130) 216 2XDF A-C:2, B-D:3 [A-C]>A: E68+AI(71,72)+EGHML(74-76,78,79)+DE(82,84)+Q111+L115+L123+R126+D129+R279 [B-D]>B: E68+AI(71,72)+EGHML(74-76,78,79)+DE(82,84)+Q111+L115+L123+R126+D129 [A-C]>C: LHTRAA(614-617,619,620)+VK(623,624)+K627+SLFK(646-649)+Q651+E685 [B-D]>D: LHTRAA(614-617,619,620)+VK(623,624)+K627+SLFK(646-649)+Q651 217 3MJG A-X:2, B-Y:3, A-Y:4, B-X:5 [A-X]>X: KK(163,164)+EDR(184-186)+YVYR(205-208)+E241+Y270 [B-X]>X: AE(132,133)+FT(138,140)+YY(205,207)+EVVNF(241-245)+PVTDF(260-264)+I272+SV(296,297) [A-Y]>Y: A132+FF(136,138)+T138+YY(205,207)+L209+EVVNF(241-245)+PVT(260-262)+F264+YI(262,264)+SV(296,297) [B-Y]>Y: K163+EDR(184-186)+VYR(206-208)+E241+DM(267,268)+Y270 [A-X]>A: E15+NNRNV(54-58)+CT(99,101) [B-Y]>B: E15+NNRNV(54-58)+CT(99-101) [A-Y]>A: R27+RTNANFL(32-38)+w40+RI(73,75)+IVRK(77-80)+F84 [B-X]>B: RR(27,28)+RTNANFL(32-38)+W40+R73+IVRKKP(77-82)+F84 218 1J7V R-L:1 [L-R]>R: YGIE(43-46)+N73+R76+NTR(94-96)+DE(100,101)+F143+VASRS(188-192) [L-R]>L: P20+LR(23,24)+RD(27,28)+KT(34,35)+QM(38,39)+Q42+DNL(44-46) 219 1Y6K R-L:1 [L-R]>R: YGIE(43-46)+N73+R76+NTR(94-96)+E101+F143+ASRS(189-192) [L-R]>L: P20+LR(23,24)+RD(27,28)+KT(34,35)+QM(38,39)+D41+LDNL(43-46) 220 3RY6 A-C:2, B-C:3 [A-C]>C: W90+W113+P117 [B-C]>C: VK(119,120)+RL(134,135)+Y160 [A-C]>A: LG(235,237)+ALP(327-329) [B-C]>B: L234+GGS(236,237,239)+VDVS(264-267)+S298 221 4K0V A-B:1 [A-B]>A: EED(150-152)+FIHS(161-164)+PR(166,167)+IG(194,195) [A-B]>B: MC(157,158)+M163+DAC(171-173)+GKL(190-192)+HY(198,199)+PS(203,204) 222 3QD6 A-S:7, C-R:8, E-T:9, F-U:10, B-R:12, C-S:13, D-T:14, E-U:15, B-T:16, D-R:17 [A-S]>A: GR(199,200)+R203+R207+E230 [C-R]>C: PGRF(198-201)+R203+E230 [E-T]>E: GR(199,200)+R203+R207+E230 [F-U]>F: GR(199,200)+R203+R207+E230 [B-R]>B: I127+LGYY(143-146)+C178+PC(217,218)+SQ(245,246)+SHGT? [A-S]>S: RETHCH(73-78)+E117 [C-R]>R: T70+RETHCH(73-78) [E-T]>T: RETHCH(73-78)+E117 [F-U]>U: RETHCH(73-78)+E117 [B-R]>R: SE(65,66)+HC(76,77)+Q79+YD(82,84)+NL(86,87)+C119 [C-S]>S: SE(65,66)+HC(76,77)+Q79+YD(82,84)+NL(86,87)+C119 [D-T]>T: SE(65,66)+H76+Q79+YD(82,84)+NL(86,87)+CV(119,120) [E-U]>U: SE(65,66)+H76+Q79+YD(82,84)+NL(86,87)+C119 [B-T]>T: E64+KT(94,96)+EE(106,107) [D-R]>R: T55 223 1QTY R-T:3, S-U:4, V-X:5, W-Y:6, R-U:7, S-T:8, V-Y:9, W-X:10, S-X:11 [R-T]>R: K48+MI(81,83)+H86+QI(89,91) [S-U]>S: K48+I83+H86+QI(89,91) [V-X]>V: K48+M81+QI(89,91) [W-Y]>W: K48+MI(81,83)+QI(89,91) [R-U]>R: FM(17,18)+WQ(21,22)+W25+DQL(63,65,66)+RP(105,106) [S-T]>S: FM(17,18)+YQ(21,22)+Y25+D63+GL(65,66)+CRP(104-106) [V-Y]>V: FM(17,18)+YQ(21,22)+Y25+DG(63,65)+RP(105,106) [W-X]>W: FM(17-18)+YQ(21,22)+Y25+DGL(63,65,66)+RP(105,106) [S-X]>S: P106 [R-T]>T: I142+I145+H147+L221+HQ(223,225) [S-U]>U: I142+H147+HQ(223,225) [V-X]>X: I142+IH(145,147)+H223 [W-Y]>Y: I142+IH(145,47)+LH(221,223) [R-U]>U: EP(141,143)+FP(172,173)+Y199+IL(202,204)+NL(219,221)+R224 [S-T]>T: EIP(141-143)+KF(171,172)+Y199+IL(202,204)+L221+R224 [V-Y]>Y: EP(141,143)+KFP(171-173)+Y199+L204+L221+R224 [W-X]>X: EP(141,143)+F172+Y199+IL(202,204)+L221+R224 [S-X]>X: K182 224 3TCX A-B:1, C-D:2, E-F:3, G-H:4, I-J:5, K-L:6, M-N:7, O-P:8, Q-R:9, S-T:10, U-V:11, W-X:12, Y-Z:13, a-b:14, C-V:28, C-X:29, I-N:39 [A-B]>A: KL(29,30)+IETPLVK(33-39)+M64+Y66+N68+Q73+K77 [C-D]>C: KL(29,30)+ETPLVK(34-39)+M64+Y66+N68+Q73+K77 [E-F]>E: KL(29,30)+ETPL(34-37)+K39+M64+Y66+N68+Q73 [G-H]>G: L30+ETPLVK(34-39)+Q62+M64+Y66+N68+Q73+K77 [I-J]>I: K29+ETPL(34-37)+K39+Q62+M64+Y66+N68+Q73 [K-L]>K: ETPL(34-37)+K39+Q62+M64+Y66+N68+Q73+T75+K77 [M-N]>M: K29+ETPL(34-37)+K39+M64+Y66+N68+Q73+K77 [O-P]>O: KL(29,30)+ETPL(34-37)+K39+M64+Y66+N68+Q73+K77 [Q-R]>Q: ETPL(34-37)+K39+Q62+M64+Y66+N68+Q73+T75+K77 [S-T]>S: K29+IETPL(33-37)+K39+Q62+M64+Y66+N68+Q73+T75+K77 [U-V]>U: ETPL(34-37)+K39+Q62+M64+Y66+N68+Q73+T75+K77 [W-X]>W: ETPL(34-37)+K39+Q62+M64+Y66+N68+Q73+T75+K77 [Y-Z]>Y: KL(29,30)+ETPLVK(34-39)+M64+Y66+N68+Q73 [a-b]>a: K29+ETPLVK(34-39)+M64+Y66+N68+Q73+T75+K77 [C-V]>C: L43 [C-X]>C: QPK(27-29)+N47 [I-N]>I: LL(42,43) [A-B]>B: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [C-D]>D: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [E-F]>F: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [G-H]>H: SMS(139-141)+LLTN(204-207)+E241+T243+KH(263,264) [I-J]>J: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [K-L]>L: SMS(139-141)+LLTN(204-207)+ET(241,243)+KH(263,264) [M-N]>N: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [O-P]>P: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [Q-R]>R: SMS(139-141)+LLTN(204-207)+ET(241,243)+KH(263,264) [S-T]>T: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [U-V]>V: SMS(139-141)+LLTN(204-207)+E241+T243+KH(263,264) [W-X]>X: SMS(139-141)+LLTN(204-207)+E241+TD(243,244)+KH(263,264) [Y-Z]>Z: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [a-b]>b: SMS(139-141)+LLTN(204-207)+E241+TDS(243-245)+KH(263,264) [C-V]>V: W189 [C-X]>X: NTS(163-165)+VK(187,188) [I-N]>N: M128+Y307 225 2W2M A-E:1 [A-E]>A: SIP(153-155)+R194+D238+I369+S372+DC(374,375)+TCFV(377-380) [A-E]>E: N295+CLD(297-299)+N301+HVCND(306-310)+L318 226 2W2N A-E:1 [A-E]>A: SIP(153-155)+R194+D238+I369+S372+DC(374,375)+TCFV(377-380) [A-E]>E: N295+CLDNN(297-301)+YVCND(306-310) 227 2W2O A-E:1 [A-E]>A: SIP(153-155)+R194+D238+I369+YC(374,375)+TCFV(377-380) [A-E]>E: N295+CLD[297-299]+N301+HVCND[306-310]+C319 228 2W2P A-E:1 [A-E]>A: SIP(153-155)+R194+D238+I369+S372+TCFV(377-380) [A-E]>E: N295+CLDNN(297-301)+HVCND(306-310)+L318 229 2W2Q A-E:1 [A-E]>A: SIP(153-155)+R194+D238+I369+HC(374,375)+TCFV(377-380) [A-E]>E: N295+CLDNN(297-301)+HVCND(306-310)+LC(318,319) 230 3BPS A-E:1 [A-E]>A: SIP(153-155)+R194+D238+I369+S372+DC(374,375)+TCFV(377-380) [A-E]>E: N295+CLD(297-299)+N301+HVCND(306-310)+L318 231 3GCW A-E:1 [A-E]>A: SIP(153-155)+R194+DA(238,239)+I369+S372+DC(374,375)+TCFV(377-380) [A-E]>E: N295+CLDNN(297-301)+YVCND(306-310) 232 3GCX A-E:1 [A-E]>A: S153+P155+R194+DA(238,239)+I369+DC(374,375)+TCFV(377-380) [A-E]>E: N295+CLDNN(297-301)+HVCND(306-310)+L318 233 3M0C B-C:2 [B-C]>B: SIP(153-155)+D238+I369+S372+YC(374,375)+TCFV(377-380) [B-C]>C: N295+LD(298,299)+N301+HVCND(306-310)+LCP(318-320) 234 3P5B A-L:1, P-L:3 [A-L]>A: SIP(153-155)+R194+DA(238,239)+I369+S372+DC(374,375)+TCFVS(377-381) [P-L]>P: L108 [A-L]>L: LD(298,299)+N301+HVCND(306-310) [P-L]>L: L626 235 3P5C P-L:3 [P-L]>P: L108 [P-L]>L: L626 236 1J7V R-L:1 [L-R]>L: P20+LR(23,24)+RD(27,28)+KT(34,35)+QM(38,39)+Q42+DNL(44-46) [L-R]>R: YGIE(43-46)+N73+R76+NTR(94-96)+DE(100,101)+F143+VASRS(188-192) 237 1IDG A-B:1 [A-B]>A: TS(8,9)+KVV(38-40)+HP(68,69) [A-B]>B: VYYTC(188-192)+PD(194,195) 238 1IDH A-B:1 [A-B]>A: T8+P10+W28+KVV(38-40)+Q71 [A-B]>B: VYYT(188-191)+PT(194,196) 239 1Y6K R-L:1 [L-R]>L: P20+LR(23,24)+RD(27,28)+KT(34,35)+QM(38,39)+D41+LDNL(43-46) [L-R]>R: YGIE(43-46)+N73+R76+NTR(94-96)+E101+F143+ASRS(189-192) 240 2KZ1 A-B:1 [A-B]>B: T44+MSKPE(46-50)+L52+D70+RS(73,74)+HE(76,77)+VTV(80-82)+S96+N98+W100+EEELQ(132-136)+DLS(138-140)+K159+HSD(187-189) [A-B]>A: QT(5,6)+RR(12,13)+LM(15,16)+R22+LFSCL(26-30)+RHDF(33-36)+AE(145,146)+MR(148,149)+S152+N156+E159+SLR(160-162)+K164 241 2LAG A-B:1 [A-B]>B: TIMSKPE(44-50)+L52+HE(76,77)+VTV(80-82)+SHN(96-98)+W100+AI(102-103)+ELQ(134-136)+DLS(138-140)+K159+EHSD(186-189)+Q191 [A-B]>A: QT(5,6)+RR(12,13)+LM(15,16)+R22+SLFSCL(25-30)+RHDF(33-36)+RAE(144-146)+MR(148,149)+SL(152,153)+E159+SR(160,162) 242 3S9D A-B:1, C-D:3 [A-B]>B: TIMSKPE(44-50)+L52+HE(76,77)+V80+V82+S96+N98+W100+AI(102,103)+H187+Q191 [C-D]>D: TIMSKPE(44-50)+HE(76,77)+V80+V82+S96+N98+W100+AI(102,103)+HS(187,188)+Q191 [A-B]>A: R12+LM(15,16)+R22+SLF(25-27)+L30+RHD(33-35)+MR(148,149)+SL(152,153)+N156 [C-D]>C: R12+LM(15,16)+R22+LF(26,27)+L30+R33+D35+MR(148,149)+SL(152,153) 243 3SE3 A-B:1, B-C:2 [A-B]>A: N68+Y70+F96+LD(131,132)+LS(134,135)+N155+Y157+TS(181,182)+H236+F238+R241+G274+I275 [B-C]>C: TIMSKPE(44-50)+HE(76,77)+V80+S96+N98+W100+I103 [A-B]>B: YN(57,58)+SQ(61,62)+FN(64,65)+D82+YT(85,86)+YQ(89,90)+LN(92,93)+E96+I116+RK(120,121)+FQ(123,124) [B-C]>B: A19+R22+SLF(25-27)+L30+RHD(33-35)+E146+MR(148,149)+SL(152,153)+N156 244 1Z92 A-B:1 [A-B]>B: LCD(2-4)+D6+M25+N27+E29+RR(35,36)+KS(38,39)+SLY(41-43)+N57+S64+YH(119,120)+K153 [A-B]>A: PK(34,35)+TR(37,38)+TFKFY(41-45)+EE(61,62)+P65+EV(68,69)+L72+CEYAD(105-109) 245 2B5I A-D:3 [A-D]>D: ELCDD(1-5)+M25+N27+E29+RR(35,36)+KSGSLY(38-43)+H120 [A-D]>A: K35+R38+FKFY(42-45)+EE(61,62)+KP(64,65)+EV(68,69)+L72+Q74+Y107 246 2ERJ A-D:1, E-H:2 [A-D]>A: LCDDD(2-6)+M25+N27+E29+RR(35,36)+KSGSLY(38-43)+N57+H120 [E-H]>E: L2+DDD(4-6)+M25+N27+E29+RR(35,36)+KSGSLY(38-43)+N57+H120 [A-D]>D: K35+TA(37,38)+TFKFY(41-45)+EE(61,62)+KP(64,65)+E68+L72+Y107 [E-H]>H: K35+R38+TFKFY(41-45)+EE(61,62)+KP(64,65)+E68+L72+C105+Y107 247 1IVO A-C:2, B-D:3 [A-C]>A: NKLTQLG(12-18)+D22+R29+Y45+L69+E90+LS(98,99)+Y101+L325+H346+DSFT(355-358)+L382+Q384+QH(408,409)+QF(411,412)+A415+V417+I438+S440+K465+S468 [B-D]>B: NKLTQLG(12-18)++D22+R29+Y45+L69+E90+LS(98,99)+L325+L348+D355+F357+Q384+QH(408,409)+QF(411,412)+A415+I438+S440+K465 [A-C]>C: HDGY(10-13)+H16+M21+I23+AL(25,26)+K28+ACNC(30-33)+V35+YIGER(37-41)+QYRDLKW(43-49)+E51 [B-D]>D: GY(12,13)+LH(15,16)+M21+I23+AL(25,26)+K28+ACNC(30-33)+V35+YIGER(37-41)+QYRDLKW(43-49)+E51 248 1NQL A-B:1 [A-B]>A: SNKLTQLG(11-18)+D22+Y45+L69+E90 [A-B]>B: M21+I23+L26+K28+ACNC(30-33)+V35+Y37+GE(39,40) 249 3NJP A-C:2, B-D:3 [A-C]>A: NKLTQ(12-16)+G18+D22+R29+Y45+L69+E90+LS(98,99)+Y101+A346+I348+R353+DSFT(355-358)+L382+Q384+QH(408,409)+QF(411,412)+A415+VS(417,418)+I438+S440+IS(467,468) [B-D]>B: NKLTQLG(12-18)+D22+R29+Y45+L69+E90+LS(98,99)+Y101+N128+H346+V350+DSFT(355-358)+L382+Q384+QH(408,409)+QF(411,412)+A415+V417+I438+SG(440,441)+K465+IS(467,468) [A-C]>C: SHDGY(9-13)+LH(15,16)+I23+AL(25,26)+K28+ACNC(30-33)+V35+IGER(38-41)+QYR(43-45)+LKW(47-49)+E51 [B-D]>D: SHDGY(9-13)+LH(15,16)+I23+AL(25,26)+K28+ACNC(30-33)+V35+IGER(38-41)+QYR(43-45)+LKW(47-49)+E51 250 1VPP V-X:2, V-Y:3, W-X:4, W-Y:5 [V-X]>V: EYPD(38-41)+QIMR(79-82)+HIGEMS(90-95) [V-Y]>V: F17 [W-X]>W: F17 [W-Y]>W: F36+IR(80,82)+QHIGEM(89-94) [V-X]>X: RGWVEICAADD(1-13)+G13 [V-Y]>Y: YG(12,13) [W-X]>X: Y12 [W-Y]>Y: RGWVEICAADD(1-11)+G13 251 1DJS A-B:1 [A-B]>B: GNYK(6-9)+Y15+S17+G19+F22+R35+R37+LSAE(46-49)+V51+VY(54,55)+K57+Y64+P79+E87+L89+NHYN(92-95)+K113+LPL(133-135)+D140 [A-B]>A: E160+EK(163,164)+LHA(166-168)+P170+D247+V249+R251+VYS(280-282)+AQPHI(284-288)+A315+VN(317,318)+D321+GNS(345-347) 252 1E0O A-B:1, C-D:2 [A-B]>A: Y15+G19+F22+R35+R37+V51+RL(88,89)+E91+HYN(93-95)+LPL(133-135) [C-D]>C: Y15+S17+GG(19,20)+F22+R35+R37+ERLEENHYN(87-95)+L133 [A-B]>B: EK(163,164)+LHAVP(166-170)+RS(251,252)+H254+IL(257,258)+A260+Y281+I350+F352 [C-D]>D: EKRLHAVP(163-170)+D247+R251+HR(254,255)+I257+QA(259,260) 253 3CU1 A-B:1, C-D:2, A-D:4, B-C:5 [A-B]>B: Y15+SNG(17-19)+R35+NHY(92-94)+L133+L135 [C-D]>D: Y15+S17+GG(19,20)+F22+R35+NHY(92-94)+K113+L133 [A-D]>D: N114 [B-C]>B: K112+N114+S116 [A-B]>A: QK(163,164)+LHA(166-168)+P170+N173+V249 [C-D]>C: EK(163,164)+LHA(166-168)+P170+N173 [A-D]>A: H213 [B-C]>C: QH(121,213) 254 3OJ2 A-C:1, B-D:2, A-D:3, B-C:4 [A-C]>A: PPG(19-21)+YK(23,24)+Y30+S32+G34+F37+R50+R52+LSAE(61-64)+V66+VY(69,70)+P94+ERL(102-104)+NHYN(107-110)+L148+L150 [B-D]>B: PPG(19-21)+YK(23,24)+Y30+S32+G34+F37+R50+R52+LSAE(61-64)+V66+VY(69,70)+P94+ERL(102-104)+NHYN(107-110)+K143+LPL(148-150) [A-D]>A: ENH(106-108) [B-C]>B: ENH(106-108) [A-C]>C: EKRLHAVP(163-170)+N173+V249+R251+P253+VYS(280-282)+AQPHI(284-288)+SGI(315-317)+E323+SNY(343-345) [B-D]>D: EKRLHAVP(163-170)+N173+D247+V249+R251+P253+VYS(280-282)+AQPHI(284-288)+SGI(315-317)+E323+SNY(343-345) [A-D]>D: HR(254,255) [B-C]>C: R255 255 3OJM A-B:1 [A-B]>A: EKF(14-16)+LPPG(18-21)+YK(23,24)+Y30+S32+G34+F37+R50+R52+L61+AE(63,64)+V66+VY(69,70)+Y79+P94+ERLE(102-105)+NHYN(107-110)+K143+L148+L150+S154 [A-B]>B: EKRLHAVP(163-170)+N173+VPS(222-224)+D247+VERSR(249-253)+Q259+KVYS(279-282)+AQPHI(284-288)+GI(316,317)+E323+NY(344,345) 256 4J23 A-B:1 [A-B]>B: NYK(22-24)+Y30+G34+R50+LSAESV(61-66)+E102+L104+NHYN(107-110)+K128+L148+L150 [A-B]>A: K161+EKRLHAVP(163-170)+N173+D247+VER(249-251)+VYS(280-282)+AQPH(284-287)+AG(315,316)+D321+GNS(345-347) 257 1EVT A-C:1, B-D:2, A-D:3, B-C:4 [A-C]>A: YK(8,9)+Y15+S17+GG(19,20)+F22+R35+L46+AESV(48-51)+V54+E87+L89+HYN(93-95)+LPL(133-135) [B-D]>B: YK(8,9)+K12+Y15+S17+G19+F22+R35+L46+AESV(48-51)+V54+E87+L89+HYN(93-95)+LPL(133-135) [A-D]>A: H93 [B-C]>B: H93 [A-C]>C: EK(162,163)+LHAVP(165-169)+D246+V248+R250+P252+V279+SDPQPH(281-286)+E324+N345 [B-D]>D: EK(162,163)+LHAVP(165-169)+D246+V248+R250+P252+V279+SDPQPHI(281-287)+A314+E324+N345 [A-D]>D: AG(259,260) [B-C]>C: AG(259,260) 258 3OJV A-C:1, B-D:2, A-D:3, B-C:4 [A-C]>A: G21+YK(23,24)+Y30+SNY(32-34)+P37+R50+R52+QLSAE(60-64)+V66+V69+Y70+E102+L104+NHYN(107-110)+LPL(148-150) [B-D]>B: G21+YK(23,24)+Y30+SNG(32-34)+F37+R50+L61+AESV(63-66)+VY(69,70)+Q102+L104+NHYN(107-110)+LPL(148,150)+V166 [A-D]>A: D43 [B-C]>B: D43 [A-C]>C: EK(162,163)+LHAVP(165-169)+D246+V248+R250+P252+VYS(279-281)+PQPH(283-286)+A314+V316+D320+E324+GN(344,345) [B-D]>D: EK(162,163)+LHAVP(165-169)+G244+D246+V248+R250+VYS(279-281)+PQPH(283-286)+A314+V316+E324+GN(344,345) [A-D]>D: Y154 [B-C]>C: Y154 259 1RY7 A-B:1 [A-B]>A: KF(15,16)+LPPGNYK(18-24)+Y30+SNG(32-34)+F37+R50+LSAESV(61-66)+V69+E102+L104+NHYN(107-110)+LPL(148-150)+D155 [A-B]>B: DK(160,161)+LLAVP(163-167)+R223+L246+R248+I254+Q256+KVYS(276-279)+QPHI(282-285)+KELE(319-322)+N343+F347 260 2VDO B-C:5 [B-C]>B: SYS(121-123)+NR(215,216)+A218+E220 B-C]>C: AG(408,409)+DV(410,411) 261 2VDP A-H:2, A-L:3 [A-L]>A: RNVGS(77-81)+R208+GI(210,211) [A-H]>A: R77+V79+Q82+L84+N149+I154+N158+SS(205,206)+I211+LWH(213-215) [A-L]>L: N32+YY(49,50)+N53+YAQL(91-94) [A-H]>H: DTY(31-33)+Y57+YDYY(101-104) 262 2VDQ A-H:2, A-L:3 [A-H]>A: R77+V79+Q82+L84+N149+I154+N158+SS(205,206)+I211+LWH(213-215) [A-L]>A: RNVGS(77-81)+RPGI(208-211) [A-H]>H: DTY(31-33)+Y57+YDYY(101-104) [A-L]>L: N32+YY(49,50)+N53+YAQL(91-94) 263 2VDR A-H:2, A-L:3 [A-H]>A: R77+V79+Q82+L84+N149+I154+N158+SS(205,206)+I211+LWH(213-215) [A-L]>A: RNVGS(77-81)+RPGI(208-211) [A-H]>H: DTY(31-33)+Y57+YDYY(101-104) [A-L]>L: N32+YY(49,50)+N53+YAQL(91-94) 264 4K3J A-B:1 [B-A]>B: TYYDD(124-128)+H148+DRF(190-192)+R218+KET(220-222)+T230+S286 [B-A]>A: RQ(533,534)+P537+D578+Y619+R647+K649+E656+CE(669,670)+Y673+VPGRGC(692-697)+R702 265 4O3T A-B:1 [A-B]>B: TYYDD(124-128)+E167+DRF(190-192)+R218+KETK(220-223)+T230+S286 [A-B]>A: Y513+K516+RQ(533,534)+P537+D578+Y619+K649+E656+CE(669,670)+Y673+VPGRGC(692-697)+R702 266 4O3U A-B:1 [A-B]>B: TYYDD(124-128)+H148+E167+DRF(190-192)+R218+KET(220-222)+LT(229,230)+S286 [A-B]>A: Y513+K516+RQ(533,534)+P537+D578+Y619+R647+K649+E656+CE(669,670)+Y673+VPGRGC(692-697)+R702 267 3U73 A-U:1 [A-U]>U: TNGD(8-11)+R25+T27+V29+E36+L38+L40+E42+RTL(53-55)+Y57+K62+LTE(66-68)+S101+VT(126,127)+KD(139,140)+L144+L150+H166+L168+DA(254,255)+S257 [A-U]>A: CVSNKYFSNI(19-28)+W30+NC(32,33)+GQ(39,40)+K46+H87 268 4K24 A-U:1 [A-U]>U: TNGD(8-11)+R25+T27+V29+E33+E36+L40+K50+RTL(53-55)+Y57+K62+LTE(66-68)+S101+VT(126,127)+EE(134,135)+KD(139,140)+L150+H166+H251+DA(254,255)+S257 [A-U]>A: SN(9,10)+CVSNKYFSNI(19-28)+W30+N32+Q40+K46+H87 269 4C2A A-B:1 [A-B]>B: SKVAS(7-11)+N16+D18+H37+TV(103,104)+Q127+K152+DT(175,176)+PF(198,199)+EN(225,226)+Y228+DVKAVTS(235-241) [A-B]>A: KW(1312,1313)+GSHAY(1324-1328)+RK(1334,1335)+E1359+KY(1362,1363)+FQ(1366,1367)+SK(1370,1371)+R1374+E1376+RN(1395,1396) 270 4C2B A-B:1, C-D:2, E-F:3, G-H:4, B-C:5, B-E:7, C-H:8, E-H:9 [A-B]>B: D18+H37+S39+V104+E128+K152+DT(175,176)+PF(198,199)+EN(225,226)+Y228+VKAVTS(236-241) [C-D]>D: E5+S7+A10+N16+H37+T103+QE(127,128)+K152+DT(175,176)+PF(198,199)+EN(225,226)+Y228+DVKAVTS(235-241) [E-F]>F: S7+V9+A10+H37+Q59+V104+QE(127,128)+K152+DT(175,176)+PF(198,199)+E225+Y228+DVKAVTS(235-241) [G-H]>H: S7+V9+S39+D63+T81+TV(103,104)+E128+K152+DT(175,176)+PF(198,199)+EN(225,226)+Y228+DVKAVTS(235-241) [B-C]>B: L117+R121+TL(138,139)+P141+A165+K189 [B-E]>B: R21+E40+L42+Y44+R64+E66+T68+Q88+Q90+R111+E135 [C-H]>H: R21+L42+Y44+R64+E66+T68+Q88+Q90+R111+R159 [E-H]>H: L117+TL(138,139)+P141+E162+A165+PK(188,189) [A-B]>A: DGSHAY(1323-1328)+R1334+E1359+K1362+FQ(1366,1367)+SK(1370,1371) [C-D]>C: K1312+DGSHAY(1323-1328)+RK(1334,1335)+I1343+E1359+K1362+FQ(1366,1367)+SK(1370,1371)+P1465 [E-F]>E: K1312+DGSHAY(1323-1328)+K1332+RK(1334,1335)+E1359+K1362+FQ(1366,1367)+SK(1370,1371)+E1376+Y1400 [G-H]>G: K1312+GSHAY(1324-1328)+G1330+RK(1334,1335)+E1359+K1362+FQ(1366,1367)+SK(1370,1371)+R1395 [B-C]>C: E1294+A1298+V1301+ER(1305,1306)+S1338+RR(1341,1342)+SQ(1345,1346) [B-E]>E: GP(1417,1418)+LK(1422,1423)+IR(1425,1426)+E1429+AFVLS(1437-1441)+E1445+Q1449+E1452 [C-H]>C: GP(1417,1418)+LK(1422,1423)+IR(1425,1426)+E1429+AFVLS(1437-1441)+E1445+QQ(1448,1449)+E1452 [E-H]>E: E1294+V1301+E1305+R1336+S1338+R1341+S1345 271 4HFZ A-B:1, A-D:3, C-D:4 [A-B]>A: L54+L57+G58+IM(61,62)+Y67+QH(72,73)+V75+VK(93,94)+H96+IY(99,100) [A-D]>A: N79+D84 [C-D]>C: L54+G58+IM(61,62)+Y67+QH(72,73)+VK(93,94)+H96+Y100 [A-B]>B: ETFS(17-20)+LW(22,23)+LLP(25-27) [A-D]>D: K24 [C-D]>D: ETF(17-19)+LW(22,23)+LP(26,27) 272 1X9T A-B [A-B]>A: V189+YL(192,193)+RQ(197,198)+E203+K387+R389+F489+LTHV(492-495)+RFPE(498-501) [A-B]>B: FNPVYP(11-16)+DT(18,19) The site residues were obtained through computing contacts by a distance ≤ 4Å. 273 4V4U D-H, A-S, B-T, E-W, C-U, D-U, E-V, A-W, B-S, C-T [D-V]>D: V189+YL(192,193)+RQ(197,198)+E203+K387+R389+F489+LTHV(492-495)+RFPE(498-501) [A-S]>A: V189+YL(192,193)+RQ(197,198)+E203+K387+R389+F489+LTHV(492-495)+RFPE(498-501) [B-T]>B: V189+YL(192,193)+RQ(197,198)+E203+K387+R389+F489+LTHV(492-495)+RFPE(498-501) [E-W]>E: V189+YL(192,193)+RQ(197,198)+E203+K387+R389+F489+LTHV(492-495)+RFPE(498-501) [C-U]>C: V189+YL(190-192)+RQ(197,198)+E203+K387+R389+F489+LTHV(492-495)+RFPE(498-501) [D-U]>D: D220+VT(222,223)+MP(227,228)+L287+V289+YQ(292,293)+K376+V378 [E-V]>E: D220+VT(222,223)+MP(227,228)+L287+V289+YQ(292,293)+K376+V378 [A-W]>A: D220+VT(222,223)+MP(227,228)+L287+V289+YQ(292,293)+K376+V378 [B-S]>B: D220+VT(222,223)+MP(227,228)+L287+V289+YQ(292,293)+K376+V378 [C-T]>C: D220+VT(222,223)+MP(227,228)+L287+V289+YQ(292,293)+K376+V378 [D-V]>V: FNPVYP(11-16)+DT(18,19) [A-S]>S: FNPVYP(11-16)+DT(18,19) [B-T]>T: FNPVYP(11-16)+DT(18,19) [E-W]>W: FNPVYP(11-16)+DT(18,19) [C-U]>U: FNPVYP(11-16)+DT(18,19) [D-U]>U: TFNP(10-13)+Y15+YD(17,18) [E-V]>V: TFNP(10-13)+Y15+YD(17,18) [A-W]>W: TFNP(10-13)+Y15+YD(17,18) [B-S]>S: TFNP(10-13)+Y15+YD(17,18) [C-T]>T: TFNP(10-13)+Y15+YD(17,18) The site residues were obtained through computing contacts by a distance ≤ 4Å. 274 1A4W I-H [I-H]>H: M32+F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82)+M84 [I-H]>I: DFEEIP(355-360)+EY(362,363) The site residues were obtained through computing contacts by a distance ≤ 4Å. 275 1DOJ A-B:1 [A-B]>A: F34+K36+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82)+M84 [A-B]>B: DFEEIP(355-360)+EKLQ(362-365) 276 1TMB I-H [I-H]>H: M32+F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82)+M84+Q151 [I-H]>I: DFEEIP(55-60)+EYL(62-64) The site residues were obtained through computing contacts by a distance ≤ 4Å. 277 1TMU J-H [J-H]>H: M32+F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+R(77A)+EKI(80-82)+M84+K109+Q151 [J-H]>J: DFEEIP(55-60)+EYLQ(62-65) The site residues were obtained through computing contacts by a distance ≤ 4Å. 278 3HAT I-H [I-H]>H: M32+F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+R(77A)+EKI(80-82)+M84 [I-H]>I: DFEEIP(55-60)+EYL(62-64) The site residues were obtained through computing contacts by a distance ≤ 4Å. 279 3P17 I-H [I-H]>H: M32+F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82)+M84+Q151 [I-H]>I: DFEEIP(555-560)+EYL(562-564) The site residues were obtained through computing contacts by a distance ≤ 4Å. 280 3QTO H-I:1 [H-I]>H: F34+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82)+M84 [H-I]>I: DFE(555-557)+IP(559，560)+EYL(562-564) 281 3QTV H-I:1 [H-I]>H: F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: GDFE(554-557)+IP(559,560)+YL(563,564) 282 3QWC H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(555-560)+YL(563,564) 283 3QX5 H-I:1 [H-I]>H: F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82)+M84 [H-I]>I: DFEEIP(555-560)+EYL(562-564) 284 3RLW H-I:1 [H-I]>H: F34+K36+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82)+M84 [H-I]>I: DFE(55-57)+IP(59,60)+EYL(62-64) 285 3RLY H-I:1 [H-I]>H: F34+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82)+M84+Q151 [H-I]>I: DFE(55-57)+IP(59,60)+EYL(62-64) 286 3RM0 H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+YL(63,64) 287 3RM2 H-I:1 [H-I]>H: F34+Q38+EL(39,40)+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I:DFEEIP(55-60)+YL(63,64) 288 3RML H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+YL(63,64) 289 3RMM H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82)+M84 [H-I]>I: DFE(55-57)+IP(59,60)+EYLQ(62-65) 290 3RMN H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+YL(63,64) 291 3RMO H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+YL(63,64) 292 3SHA H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+YL(63,64) 293 3SHC H-I:1 [H-I]>H: F34+K36+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFE(55-57)+IP(59,60)+YL(63,64) 294 3SI3 H-I:1 [H-I]>H: F34+K36+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFE(55-57)+IP(59,60)+YL(63,64) 295 3SI4 H-I:1 [H-I]>H: F34+Q38+EL(39,40)+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+YL(63,64) 296 3SV2 H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+YL(63,64) 297 3T5F H-I:1 [H-I]>H: F34+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFE(55-57)+IP(59,60)+Y63 298 3TU7 H-I:1 [H-I]>H: F34+K36+Q38+L40+L65+R67+RTRY(73-76)+KI(81,82) [H-I]>I: DFE(55-57)+IP(59,60)+YL(63,64) 299 3U98 H-I:1 [H-I]>H: F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFE(55-57)+IP(59,60)+YLQ(63-65) 300 3U9A H-I:1 [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [H-I]>I: DFEEIP(55-60)+Y63 301 3UWJ I-H [I-H]>H: M32+F34+K36+S(36A)+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82)+M84+Q151 [I-H]>I: DFEEIP(55-60)+EYLQ(62-65) The site residues were obtained through computing contacts by a distance ≤ 4Å. 302 4BAO D-B [D-B]>B: M53+F55+K57+QEL(60-62)+L96+R98+RTRY(104-107)+EKI(112-114)+M116+Q186 [D-B]>D: DFEEIP(355-360)+EYL(362-364) The site residues were obtained through computing contacts by a distance ≤ 4Å. 303 4E7R G-J:2, H-I:4 [G-J]>G: F1034+Q1038+L1040+L1065+R1067+RTRY(1073-1076)+EKI(1080-1082) [H-I]>H: F34+Q38+L40+L65+R67+RTRY(73-76)+EKI(80-82) [G-J]>J: DFEEIP(1555-1560)+YL(1563,1564) [H-I]>I: DFE(555-557)+IP(559,560)+YL(563,564) 304 4LOY I-H [I-H]>H: M32+F34+K36+S(36A)+QEL(38-40)+L65+R67+RTRY(73-76)+N78+EKI(80-82)+M84 [I-H]>I: DFEEIP(55-60)+EYL(62-64) The site residues were obtained through computing contacts by a distance ≤ 4Å. 305 4N3L I-H [I-H]>H: M32+F34+K36+S(36A)+QEL(38-40)+L65+R67+RTRY(73-76)+EKI(80-82)+M84+Q151 [I-H]>I: DFEEIP(55-60)+EYL(62-64) The site residues were obtained through computing contacts by a distance ≤ 4Å. 306 4NZE I-H [I-H]>H: M32+F34+K36+QEL(38-40)+L65+R67+RTRY(73-76)+EKISM(80-84)+Q151 [I-H]>I: FEEIP(56-60)+EY(62,63) The site residues were obtained through computing contacts by a distance ≤ 4Å. 307 2L29 A-B:1 [A-B]>A: YSKS(1542-1545)+F1567+QT(1569,1570)+I1572+P1597+PS(1599,1600)+S1602+L1629+K1631 [A-B]>B: R3+GE(11,12)+DT(15,16)+QF(18,19)+GD(22,23)+SCDL(50-53)+E57 308 2V5P A-D:2, B-C:3 [A-D]>A: YSE(1542-1544)+F1567+QT(1569,1570)+P1597+PS(1599,1600)+L1629+K1631+L1636 [B-C]>B: YSE(1542-1544)+FGQT(1567-1570)+I1572+P1597+PS(1599,1600)+L1629+K1631 [A-D]>D: E6+L8+E12+D15+QF(18,19)+GD(22,23)+CDL(51-53)+E57 [B-C]>C: E6+L8+GE(11,12)+DT(15,16)+QF(18,19)+GD(22,23)+CDL(51-53)+E57 309 3EHT A-B:1 [A-B]>A: LI(50,51)+RV(96,97)+Y99+Q103 [A-B]>B: R35+LMEII(37-41)+NH2(42) 310 3EHU A-C:2, B-D:3, A-D:4, B-C:5 [A-C]>A: LI(50,51)+FY(72,73)+V75+Y77+RV(96,97)+Y99+E104 [B-D]>B: LI(50,51)+FY(72,73)+V75+Y77+RV(96,97)+Y99+E104 [A-D]>A: I40+L50 [B-C]>B: L50 [A-C]>C: QA(30,31)+N34+LMEII(37-41)+NH2(42) [B-D]>D: QA(30,31)+N34+LMEII(37-41)+NH2(42) [A-D]>D: I41 [B-C]>C: I40 311 1R2B(196) A-C:2, A-D:3, B-C:4, B-D:5 [A-C]>A: MAC(51- 53)+G55+HV(116,117)+T120+K123 [A-D]>A: DSQIQFTRH(6-14)+DV(17,18)+LN(20,21)+NR(23,24)+SR(27,28) [B-C]>B: DSQIQFTRH(6-14)+DV(17,18)+N21+R24+R28 [B-D]>B: MACSG(51-55)+Y58+HV(116,117)+T120+K123 [A-C]>C: E1420+RSIH(1423-1426) [A-D]>D: VATVKEAGRSIHEIPR(1415-1430) [B-C]>C: S0+VATVKEAGRSIHEIPR(1415-1430) [B-D]>D: E1420+RSIH(1423-1426)+I1428 312 3BIM(196) [A-I]:5, [B-J]:6, [C-K]:7, [E-M]:8, [G-O]:9, [H-P]:10, [A-J]:11, [B-I]:12, [D-K]:13, [F-M]:14, [G-P]:15, [H-O]:16, [A-N]:17, [C-L]:23, [E-N]:24, [C-N]:25, [D-L]:26, [F-N]:27, [D-N]:28, [E-K]:29 [A-I]>A: MACSG(51-55)+Y58+MEH(114- 116)+T120 [B-J]>B: MACSG(51- 55)+Y58+EH(115,116)+T120 [C-K]>C: MACSG(51-55)+Y58+EH(115,116) [E-M]>E: MACSG(51- 55)+Y58+Q113+EH(115,116) [G-O]>G: MACSG(51- 55)+Y58+R94+EH(115,116) [H-P]>H: MACSG(51-55)+Y58+EH(115,116) [A-J]>A: DSQIQFTR(6-13)+D17+N21+R24+R28 [B-I]>B: DSQIQFTR(6-13)+D17+N21+RL(24,25)+R28 [D-K]>D: D6+QIQFTR(8-13)+D17+N21+R24+R28 [F-M]>F: DSQIQFTR(6-13)+D17+N21+RL(24,25)+R28 [G-P]>G: SQIQFTR(7-13)+D17+N21+R24+R28 [H-O]>H: DSQIQFTR(6-13)+D17+N21+RL(24,25)+R28 [A-N]>A: Q64 [C-L]>C: QIQFTR(8-13)+D17+N21+R24+R28 [E-N]>E: DSQIQFTR(6- 13)+D17+N21+RL(24,25)+R28 [C-N]>C: T62+Q64 [D-L]>D: MACSG(51-55)+Y58+EH(115,116) [F-N]>F: MACSG(51- 55)+Y58+EH(115,116)+T120 [D-N]>D: R28 [E-K]>E: S27+D29+V35+Q42+R44 A-I]>I: S503+PSSW(506-509)+P512 [B-J]>J: S503+PSSW(506-509)+P512 [C-K]>K: PSSW(506-509)+V511 [E-M]>M: PSSW(506-509)+VP(511,512) [G-O]>O: PSSW(506-509)+VP(511,512) [H-P]>P: PSSW(506-509)+P512 [A-J]>J: RS(498,499)+IIST(501,504)+PS(506,507)+WVVP(509-512) [B-I]>I: RSEIIST(498-504)+PS(506,507)+WVVP(509-512)+P514 [D-K]>K: RSEIISTAPS(498-507)+WVVPGP(509-514) [F-M]>M: RSEIIST(498-504)+PS(506,507)+WVVPGP(509-514) [G-P]>P: RSEIISTAPS(498-507)+WVVPGP(509-514) [H-O]>O: RSEIISTA(498-505)+S507+WVVP(509-512)+P514 [A-N]>N: G513 [C-L]>L: SEIISTA(499-505)+PS(506,507)+WVVPG(509-513) [E-N]>N: SEIIST(499-504)+PS(506,507)+WVVPG(509-513) [C-N]>N: P512+P514 [D-L]>L: PSSW(506-509)+VP(511,512) [F-N]>N: PSSW(506-509)+VP(511,512) [D-N]>N: P514 [E-K]>K: PSSW(506-509)+P512 313 2OSL 314 4QT8 A-C:2, B-D:3, A-D:4 [A-C]>A: AL(128,129)+E190+GQASY(192-196)+R220+KA(222,223)+V233+TEPE(286-289)+H424 [B-D]>B: D64+A128+E190+GQASY(192-196)+R220+KA(222,223)+TEPE(286-289)+H424 [A-D]>A: PG(644,646) [A-C]>C: RQ(521,522)+SSCH(525-528)+S565+Q568+R639+R641+E644+E658+PNR(681-683) [B-D]>D: RQ(521,522)+SSCH(525-528)+S565+Q568+RR(637,639)+E644+E658+PNR(681-683) [A-D]>D: Q502+GE(533,535)+P556 315 4QT8 A-C:2, B-D:3, A-D:4 [A-C]>A: AL(128,129)+E190+GQASY(192-196)+R220+KA(222,223)+V233+TEPE(286-289)+H424 [B-D]>B: D64+A128+E190+GQASY(192-196)+R220+KA(222,223)+TEPE(286-289)+H424 [A-D]>A: PG(644,646) [A-C]>C: RQ(521,522)+SSCH(525-528)+S565+Q568+R639+R641+E644+E658+PNR(681-683) [B-D]>D: RQ(521,522)+SSCH(525-528)+S565+Q568+RR(637,639)+E644+E658+PNR(681-683) [A-D]>D: Q502+GE(533,535)+P556 316 3M17 A-I,C-J,E-K,G-L,G-K [A-i]>A:A81+GG(83,84)+Y88+LN(112,113)+E115+WPE(131-133) [C-J]>C:ALGG(81-84)+Y88+LN(112,113)+E115+WPE(131-133) [E-K]>E:ALGG(81-84)+Y88+LN(112,113)+E115+WPE(131-133) [G-L]>G:ALGG(81-84)+Y88+LN(112,113)+E115+WPE(131-133)+A136 [G-K]>G:QP(261,262) [A-I]>I:TGHFG(Sar)(4-9)+Y(11) [C-J]>J:TGHFG(Sar)(Mle)Y(4-11)+(LE)13 [E-K]>K:TGHFG(Sar)(Mle)Y(4-11) [G-L]>L:TGHF(4-7)+(Sar)9+Y11+(LE)13 [G-K]>K:C13+(NH)214 The consensus motif was discovered Using peptide phage display screening, Gly-His-Phe-Gly-Gly-X-Tyr, where X is preferably a hydrophobic amino acid. The motif is enclosed by a cysteine disulfide loop forming an 11-amino acid loop including the cysteines. The peptide was optimized for inhibition of IgG binding to FcRn and stability in plasma, resulting in monomeric peptide1 SYN1327 and dimeric peptide3 SYN1436. The structures of peptides 1 and 3 in complex with degshFcRn and diffraction data have been deposited with the RCSB Protein Data Bank (entry IDs: 3M17 and 3M1B,respectively). 317 3M1B A-I,C-J [A-I]>A:ALGG(81-84)+Y88+LN(112,113)+E115+WPE(131-133) [C-J]>C:GG(83,84)+Y88+L112+E115+WPE(131-133)+A136 [A-I]>I:TGHFG(Sar)(4-9)+Y11 [C-J]>J:TGHF(104-107)+Y111 The consensus motif was discovered Using peptide phage display screening, Gly-His-Phe-Gly-Gly-X-Tyr, where X is preferably a hydrophobic amino acid. The motif is enclosed by a cysteine disulfide loop forming an 11-amino acid loop including the cysteines. The peptide was optimized for inhibition of IgG binding to FcRn and stability in plasma, resulting in monomeric peptide1 SYN1327 and dimeric peptide3 SYN1436. The structures of peptides 1 and 3 in complex with degshFcRn and diffraction data have been deposited with the RCSB Protein Data Bank (entry IDs: 3M17 and 3M1B,respectively). 318 2FYL A-B:1 [A-B]>B:R16+I18+LDD(26,28)+S37+CA(53,54)+R57+I59+D66+D68+C71+DA(73,74)+G79+H82 [A-B]>A:R21+K24+Q27+EK(30,31)+R34+L57+K60+LD(64,65)+E74+GK(92,93) 319 4KM6 320 4KM7 321 4KMX 322 4LRH 323 5TZQ 324 3LB6 A-C:1,A-D:2,B-D:3 [A-C]>A: R11+E15+M33+DTKIE(87-91)+L101+KK(104,105)+FREG(107-110) [A-D]>A: EGR(109-111) [B-D]>B: R11+IE(14,15)+V18+M33+DTKIE(87-91)+101L+KK(104,105)+FREG(107-110) [A-C]>A: R11+E15+M33+DTKIE(87-91)+L101+KK(104,105)+FREG(107-110) [A-D]>A: EGR(109-111) [B-D]>B: R11+IE(14,15)+V18+M33+DTKIE(87-91)+101L+KK(104,105)+FREG(107-110)