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Pulmonary Tuberculosis

Pulmonary Tuberculosis (PTB) is a chronic infectious disease caused by Mycobacterium tuberculosis and is a major cause of infectious disease-related deaths, recognized as a significant global public health concern. The clinical manifestations of pulmonary tuberculosis primarily include cough, hemoptysis, chest pain, fatigue, fever, night sweats, loss of appetite, and weight loss. Without timely diagnosis and treatment, it can result in severe lung tissue damage, posing a serious threat to the patient's health and life.

Diagnosis

Accurate and prompt diagnosis is crucial for controlling the burden of pulmonary tuberculosis. However, existing diagnostic methods each have their limitations. For instance, sputum culture takes a long time to yield results, chest X-ray results alone are not definitive, and Xpert MTB/RIF has relatively low accuracy in HIV-positive patients and depends on induced sputum. Therefore, the search for new diagnostic methods for pulmonary tuberculosis is essential. Diagnostic methods based on host blood transcriptome biomarkers hold potential for rapid and accurate diagnosis of pulmonary tuberculosis.

What is PTBD？

PTBD is a tool used for the diagnosis of pulmonary tuberculosis, accurately determining whether a subject has pulmonary tuberculosis, thereby contributing to reducing the burden of tuberculosis.

This tool is based on a logistic regression model trained using a large dataset of samples from multiple countries and disease categories. It has the following advantages:

Only requires the expression values of a few genes from whole blood.
Applicable to the real world, effective for different age groups and countries, not affected by special factors.
Model achieved an AUC of 0.909 in an external validation set, and meeting WHO community triage test standards.
Can diagnose extrapulmonary tuberculosis and predict pulmonary tuberculosis treatment effectiveness.