BDB - Template Details

BiopanningDataSet
Target
Template
Library
Structure

Template

Template Name: Receptor tyrosine-protein kinase erbB-2

Template ID:

Template Type:

Protein>Receptor

Template Sequence:

P04626

Synonyms:

p185erbB2
Proto-oncogene c-ErbB-2
Proto-oncogene Neu
Tyrosine kinase-type cell surface receptor HER2
Metastatic lymph node gene 19 protein, MLN 19
CD_antigen=CD340
EC=2.7.10.1

Template Source:

Homo sapiens (Human):9606

Template Structure:

1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3MZW, 3N85, 3PP0, 3RCD

Comments:

HER2 is a receptor tyrosine kinase embedded in the cell membrane. It is involved in the signal transduction pathways leading to cell growth and differentiation. In some cancers, notably some breast cancers, HER2 is over-expressed, which causes breast cells to reproduce uncontrollably.

First |

Prev |

| Next

| Last