BDB - Target Details

Target

Target Name: Fc domain of IgG (IGHG1,IGHG2,IGHG3,IGHG4)

Target ID:

1098

Target Type:

Protein>Others

Target Sequence:

P01857 , P01859 , P01860 , P01861

Synonyms:

Ig gamma chain C region, Human IgG Fc fragment

Target Source:

Homo sapiens (Human):9606

Target Structure:

IGHG1: 1AJ7, 1AQK, 1BEY, 1D5B, 1D5I, 1D6V, 1DFB, 1DN2, 1E4K, 1FC1, 1FC2, 1FCC, 1GAF, 1H3T, 1H3U, 1H3V, 1H3W, 1H3X, 1H3Y, 1HKL, 1HZH, 1I7Z, 1L6X, 1N7M, 1OP3, 1OQO, 1OQX, 1T83, 1T89, 1VGE, 2DTS, 2GJ7, 2I5Y, 2IWG, 2J6E, 2JB5, 2JB6, 2O5X, 2O5Y, 2O5Z, 2OSL, 2QAD, 2QL1, 2QQK, 2QQL, 2QQN, 2QR0, 2R56, 2RCJ, 2RCS, 2VXQ, 2WAH, 3AGV, 3AVE, 3AY4, 3B2U, 3B2V, 3BDY, 3BE1, 3BKY, 3BN9, 3BQU, 3C08, 3C09, 3C2S, 3CFJ, 3CFK, 3CSY, 3D0L, 3D0V, 3D6G, 3D85, 3DJ9, 3DNK, 3DO3, 3DRO, 3DRQ, 3DVG, 3DVN, 3EYF, 3EYO, 3EYQ, 3FJT, 3O11, 3RY6, 3S7G, 3SGJ, 3SGK, 3TV3, 3TWC, 3TYG, 3U0W, 3U7W, 3U7Y, 3V7M, 3V8C, 3V95, 3WJJ, 3WJL, 3WKN, 3WN5, 4ACP, 4B7I, 4BM7, 4BSV, 4BSW, 4BYH, 4CDH, 4D9Q, 4D9R, 4DAG, 4DZ8, 4EOW, 4J12, 4KU1, 4LLD, 4LLM, 4LLQ, 4N0U, 4NQS, 4NQT, 4NQU, 4NWT, 4NWU, 4O4Y, 4O51, 4Q6Y, 4Q74, 4Q7D, 4W4N, 4W4O, 4X4M
IGHG2: 2QSC, 4HAF, 4HAG, 4L4J
IGHG4: 1ADQ, 1BBJ, 2FL5, 4B53, 4C54, 4C55, 4D2N

Comments:

Defects in IGHG1 are a cause of multiple myeloma, which is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection.

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