Therapeutic antibodies are widely used in treating various diseases such as autoimmune diseases, cancer, inflammation, and infectious diseases. Protein which with cross-interaction or/and self-interaction can easily produce aggregation or precipitation, or increase in viscosity of solution. The CISI2.0 is a predictor that can be used to predict Cross-interaction or/and Self-interaction of monoclonal antibodies using sequences. The predictor was built using Support Vector Machine.
Notice:
(1) Please enter sequence in FASTA format or upload a .fasta file.
(2) The heavy chain and light chain should be enter respectively.
(3) The sequence consist only of heavy or light chains is allowed.
(4) Please do not submit sequences through text box and file box simultaneously.
(5) The name of heavy chain and light chain in one antibody must be same,Otherwise they will be regarded as two antibodies.