General information
    ACovPid:ACoVP100415
    Trivial Name:N3G
    Amino Acids Sequence:(IEEIVKKIHHIERAIEAQQKLLQLTVWGIKQLQARIL)3
    Length:111
    C-Terminal Modification:None
    N-Terminal Modification:None
    Chemical Modification:None
    Peptide Source:

    Human immunodeficiency virus -1 gp41 : 33929200

    Source Description:We engineered the mimetic of the gp41 HR1 helical trimer, designated N3G, on the basis of the N37 sequence and the use of combined strategies, including isoleucine substitution at the a–d sites in the second heptad, intrahelical salt-bridge introduction i
    Against Virus:

    Human coronavirus OC43 (HCoV-OC43) : 31631

    Inhibition Value Type:IC50
    Inhibitory Effect:6.62 ± 1.78
    Inhibitory Unit:µM
    Target Domain Name:HR2 domain of HCoV-OC43
    Assay:in Vitro assay
    Assay Description:The inhibitory activity of peptides against HCoV-OC43 replication in the RD cell line was measured as previously reported (PMID: 30989115). Diluted peptides and HCoV-OC43 (100 TCID50) were incubated at 37 °C. After 30 min, mixed solutions containing diluted peptides and HCoV-OC43 were added to RD cells in a 96-well plate. After 3 days, the cytopathic effect was measured with a Cell Counting Kit-8 (CCK-8) assay.
    Anti-CoV activity in vivo:
    Reference:33929200
    Comment:
    3D structure:

    Structure Experiment Verified:
    Similar Peptides:ACoVP100407   

    Target Domain information
    Target Domain Full Name:Heptad repeat 2(HR2) domain of Human coronavirus OC43 (HCoV-OC43) spike glycoprotein
    Target Type:glycoprotein
    UniprotID [Sequence]:

    P36334 [1248-1286]

    Target Synonyms:Alternative name(s) for spike glycoprotein: E2 Peplomer protein S glycoprotein
    Target Source:

    Human coronavirus OC43 (HCoV-OC43) : 31631

    Target Structure: