General information
    ACovPid:ACoVP100413
    Trivial Name:N1G
    Amino Acids Sequence:IEEIVKKIHHIERAIEAQQKLLQLTVWGIKQLQARIL
    Length:37
    C-Terminal Modification:None
    N-Terminal Modification:None
    Chemical Modification:None
    Peptide Source:

    Human immunodeficiency virus -1 gp41 : 33929200

    Source Description:We engineered the mimetic of the gp41 HR1 helical trimer, designated N3G, on the basis of the N37 sequence and the use of combined strategies, including isoleucine substitution at the a–d sites in the second heptad, intrahelical salt-bridge introduction i
    Against Virus:

    Human coronavirus OC43 (HCoV-OC43) : 31631

    Inhibition Value Type:IC50
    Inhibitory Effect:>20
    Inhibitory Unit:µM
    Target Domain Name:HR2 domain of HCoV-OC43
    Assay:Cell–cell fusion assay
    Assay Description:Briefly, HEK293T cells were transfected with plasmid pAAV-IRES-GFP-OC43-S. Thirty-six hours later, HEK293T cells co-expressing EGFP and OC43 spike protein were harvested and co-incubated with diluted peptides at 37 °C for 30 min. Then, 293T cells were transferred and co-incubated with Huh-7 cells in the presence of trypsin for 24 h. The inhibition rate was calculated according to the numbers of fused and unfused cells.
    Anti-CoV activity in vivo:
    Reference:33929200
    Comment:
    3D structure:

    StructureACoVP100413

    Structure Experiment Verified:NO
    Similar Peptides:ACoVP100406   

    Target Domain information
    Target Domain Full Name:Heptad repeat 2(HR2) domain of Human coronavirus OC43 (HCoV-OC43) spike glycoprotein
    Target Type:glycoprotein
    UniprotID [Sequence]:

    P36334 [1248-1286]

    Target Synonyms:Alternative name(s) for spike glycoprotein: E2 Peplomer protein S glycoprotein
    Target Source:

    Human coronavirus OC43 (HCoV-OC43) : 31631

    Target Structure: