| General information | |
| ACovPid: | ACoVP100413 |
| Trivial Name: | N1G |
| Amino Acids Sequence: | IEEIVKKIHHIERAIEAQQKLLQLTVWGIKQLQARIL |
| Length: | 37 |
| C-Terminal Modification: | None |
| N-Terminal Modification: | None |
| Chemical Modification: | None |
| Peptide Source: | Human immunodeficiency virus -1 gp41 : 33929200 |
| Source Description: | We engineered the mimetic of the gp41 HR1 helical trimer, designated N3G, on the basis of the N37 sequence and the use of combined strategies, including isoleucine substitution at the a–d sites in the second heptad, intrahelical salt-bridge introduction i |
| Against Virus: | Human coronavirus OC43 (HCoV-OC43) : 31631 |
| Inhibition Value Type: | IC50 |
| Inhibitory Effect: | >20 |
| Inhibitory Unit: | µM |
| Target Domain Name: | HR2 domain of HCoV-OC43 |
| Assay: | Cell–cell fusion assay |
| Assay Description: | Briefly, HEK293T cells were transfected with plasmid pAAV-IRES-GFP-OC43-S. Thirty-six hours later, HEK293T cells co-expressing EGFP and OC43 spike protein were harvested and co-incubated with diluted peptides at 37 °C for 30 min. Then, 293T cells were transferred and co-incubated with Huh-7 cells in the presence of trypsin for 24 h. The inhibition rate was calculated according to the numbers of fused and unfused cells. |
| Anti-CoV activity in vivo: | |
| Reference: | 33929200 |
| Comment: | |
| 3D structure: | |
| Structure Experiment Verified: | NO |
| Similar Peptides: | ACoVP100406 |
| Target Domain information | |
| Target Domain Full Name: | Heptad repeat 2(HR2) domain of Human coronavirus OC43 (HCoV-OC43) spike glycoprotein |
| Target Type: | glycoprotein |
| UniprotID [Sequence]: | P36334 [1248-1286] |
| Target Synonyms: | Alternative name(s) for spike glycoprotein: E2 Peplomer protein S glycoprotein |
| Target Source: | Human coronavirus OC43 (HCoV-OC43) : 31631 |
| Target Structure: | |