| General information | |
| ACovPid: | ACoVP100368 |
| Trivial Name: | Octapeptide |
| Amino Acids Sequence: | AVLQSGFR |
| Length: | 8 |
| C-Terminal Modification: | None |
| N-Terminal Modification: | None |
| Chemical Modification: | None |
| Peptide Source: | Severe acute respiratory syndrome coronavirus (SARS-CoV) : 694009 |
| Source Description: | From the Structure of SARS-CoV Mpro |
| Against Virus: | Severe acute respiratory syndrome coronavirus (SARS-CoV) : 694009 |
| Inhibition Value Type: | EC50 |
| Inhibitory Effect: | 0.027 |
| Inhibitory Unit: | µg/mL |
| Target Domain Name: | |
| Assay: | |
| Assay Description: | The toxicity of the octapeptide in Vero cells was assessed and its antiviral activity was measured with SARS coronavirus BJ-01 strain, which was isolated from a SARS patient in Beijing, China. The cytopathogenicity induced by the virus 24–96 h after infection in 96-well microplates on confluent layers of Vero cells was visually scored. The selectivity index was determined as the ratio of the concentration of the octapeptide that reduced cell viability to 50% (CC50) to the concentration of the octapeptide needed to inhibit the cytopathic effect to 50% of the control value (EC50). |
| Anti-CoV activity in vivo: | |
| Reference: | 16242214 |
| Comment: | |
| 3D structure: | |
| Structure Experiment Verified: | NO |
| Similar Peptides: | |